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Acides nucléiques antisens --- Antisense nucleic acids --- Antisense nucleinezuren --- Genetic regulation --- Genetische regulatie --- Régulation génétique --- Antisense nucleic acids. --- Genetic regulation. --- DNA, Antisense. --- Gene Expression Regulation. --- RNA, Antisense. --- Dna, antisense. --- Gene expression regulation. --- Rna, antisense.

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MicroRNA (miRNA) is a cutting-edge topic in the scientific and medical fields. This is a timely and specialized book focusing on the current understanding of miRNAs and the potential for their application in cancer diagnosis, prognosis, and therapeutic targets. It also provides discussion of the lessons learned from translational miRNA studies and exploration of the next steps required to advance this field. The unique book comprises 22 in-depth chapters by gathering unparalleled topics of interest in miRNAs by international team of world-renowned experts in the field. The first fifteen chapters provide comprehensive and expert perspectives on the most common cancers from bench to bedside applications, there is no current book structured in this cancer-oriented way. The next seven chapters providing thorough overviews of miRNAs and cancer stem cells; miRNAs in cancer invasion and metastasis; miRNAs in predicting radiotherapy and chemotherapy response; as well as expounding the role of miRNA in anti-cancer drug resistance and as blood-based cancer biomarkers. Furthermore, this book explicates the interplay of miRNAs in cancer metabolism and an update on the pioneering RNAi-based treatment approaches is also presented. This specialized book will contribute great to the scientific and medical community by providing the up-to-date discoveries of miRNAs and their important roles in cancer translational research.

Cancer -- Genetic aspects. --- Cancer -- Research. --- Neoplasms -- diagnosis. --- Neoplasms -- Genetics. --- Neoplasms -- Research. --- Diseases --- RNA, Antisense --- RNA, Small Untranslated --- RNA, Untranslated --- RNA --- Antisense Elements (Genetics) --- Nucleic Acids, Nucleotides, and Nucleosides --- Nucleic Acids --- Chemicals and Drugs --- Neoplasms --- MicroRNAs --- Medicine --- Health & Biological Sciences --- Oncology --- Cancer --- Genetic translation. --- Genetic aspects. --- Treatment. --- Translation (Genetics) --- Cancer therapy --- Cancer treatment --- Cancer genetics --- Therapy --- Medicine. --- Cancer research. --- Human genetics. --- Biomedicine. --- Biomedicine general. --- Cancer Research. --- Human Genetics. --- Genetic code --- Genetic regulation --- Cancer genes --- Oncology. --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Tumors --- Clinical sciences --- Medical profession --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biomedicine, general. --- Cancer research

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This book provides comprehensive descriptions of the innovative strategies and methodologies for detecting miRNA expression, their application in miRNA research and their potential as tools for clinical diagnosis and prognosis. It begins with the introduction of the overall concept and strategies of miRNA expression detection methods emphasizing the need of a wide variety of these methods to suit specific requirements for research and clinical examination in laboratories. In the following, each single chapter focuses on an independent, unique method of miRNA detection and is divided into five subsections: summary, introduction, protocol (including materials, instrument, reagent, and procedure), application and limitation, and reference. The development of the technique, the ideas behind it and the mechanisms underlying the method are given in the introduction of each chapter. The step-by-step protocols are detailed in the protocol section. Then, the applications and limitations of the methods are discussed. Finally, the literature citations are listed in reference section. Schematic diagrams are included where needed and appropriate for better illustrating the principle of the methodologies. In addition, flowcharts are also provided to outline the protocols for each of the miRNA expression detection methods. This book is aimed to target both researchers involved in miRNA research of any fields in universities and research institutions and medical practitioners who are interested in developing or utilizing miRNA profiling as a complementary and an alternative strategy for clinical diagnosis of human disease.

MicroRNA. --- RNA --- Gene expression --- RNA, Small Untranslated --- Investigative Techniques --- RNA, Antisense --- Genetic Techniques --- Antisense Elements (Genetics) --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- RNA, Untranslated --- MicroRNAs --- Methods --- Gene Expression Profiling --- Nucleic Acids, Nucleotides, and Nucleosides --- Nucleic Acids --- Chemicals and Drugs --- Biology --- Human Anatomy & Physiology --- Health & Biological Sciences --- Cytology --- Animal Biochemistry --- Gene expression. --- Genetic regulation. --- Gene expression regulation --- Gene regulation --- Genes --- Regulation --- Expression --- Life sciences. --- Gene therapy. --- Pharmacology. --- Biochemistry. --- Cell biology. --- Life Sciences. --- Cell Biology. --- Biochemistry, general. --- Gene Expression. --- Pharmacology/Toxicology. --- Gene Therapy. --- Genetic regulation --- Biosynthesis --- Cellular control mechanisms --- Molecular genetics

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The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.RNA Interference will cover RNAi in non-vertebrates (plants, C. elegans, drosophila, and S. pombe), and Mammalian systems (human and non-human cells). This volume discusses e

RNA Interference. --- Small interfering RNA. --- RNA Interference --- RNA, Small Interfering --- Gene Silencing --- Epigenesis, Genetic --- RNA, Antisense --- RNA, Small Untranslated --- RNA --- Antisense Elements (Genetics) --- RNA, Untranslated --- Gene Expression Regulation --- Nucleic Acids, Nucleotides, and Nucleosides --- Genetic Processes --- Nucleic Acids --- Genetic Phenomena --- Chemicals and Drugs --- Phenomena and Processes --- RNA editing --- Gene silencing --- Small interfering RNA --- piRNA (Piwi-interacting RNA) --- Piwi-interacting RNA --- Piwi protein-interacting RNA --- rasiRNA (Repeat-associated small interfering RNA) --- Repeat-associated siRNA --- Repeat-associated small interfering RNA --- Scan RNA --- scnRNA (Small scan RNA) --- Short hairpin RNA --- Short interfering RNA --- shRNA (Short hairpin RNA) --- siRNA (Small interfering RNA) --- Small hairpin RNA --- Small scan RNA --- tasiRNA (Trans-acting small interfering RNA) --- Trans-acting siRNA --- Trans-acting small interfering RNA --- Gene inactivation --- Inactivation, Gene --- Silencing, Gene --- Editing, RNA --- Messenger RNA editing --- mRNA editing --- Ribonucleic acid --- Ribose nucleic acid --- Antisense RNA --- Genetic regulation --- Nucleic acids --- Ribose

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Aberrant expression and function of microRNAs (miRNAs) in cancer have added a new layer of complexity to the understanding of development and progression of the disease state. It has been demonstrated that miRNAs play a momentous role in oncogenesis via regulating cell proliferation and apoptosis as oncogenes or tumour suppressors. Expression signatures of miRNAs offer exciting opportunities for crafting cutting edge strategies in the diagnosis, prognosis, and therapy of cancer. Since miRNAs can function as either oncogenes or tumor suppressor genes in the tortuous route of oncogenesis, the promise represented by using these small RNAs as therapeutic targets presents new perspectives to the landscape of cancer therapy by either inhibiting or augmenting their activity. This book devotes efforts to provide a broad framework for obtaining an in depth understanding of the state-of-the-art knowledge on abnormalities of miRNAs found to be associated with cancer pathogenesis and possible mechanisms underlying the substantial roles played by miRNAs in cancer development and progression. Also, it intends to pave the way for readers to gain novel insights into using miRNAs as cancer biomarkers and therapeutic platforms.

Carcinogenesis --- RNA --- Medical microbiology --- RNA, Antisense --- Antisense Elements (Genetics) --- Nucleic Acids, Nucleotides, and Nucleosides --- Chemicals and Drugs --- MicroRNAs --- Medicine --- Health & Biological Sciences --- Oncology --- Carcinogenesis. --- RNA. --- Medical microbiology. --- Ribonucleic acid --- Ribose nucleic acid --- Cancer --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Pathogenesis --- Medicine. --- Cancer research. --- Human genetics. --- Gene expression. --- Medical genetics. --- Drug resistance. --- Molecular biology. --- Biomedicine. --- Cancer Research. --- Human Genetics. --- Gene Expression. --- Gene Function. --- Molecular Medicine. --- Drug Resistance. --- Nucleic acids --- Ribose --- Pathology --- Genetic toxicology --- Oncology. --- Drug interactions. --- Interactions, Drug --- Drugs --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Genetic disorders --- Genes --- Genetic regulation --- Genetics --- Heredity, Human --- Physical anthropology --- Tumors --- Side effects --- Genetic aspects --- Expression --- Health Workforce --- Resistance to drugs --- Pharmacology --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cancer research