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The objective of this document is to provide guidance to risk assessors on the use of quantitative toxicokinetic and toxicodynamic data to address interspecies and interindividual differences in dose/concentration-response assessment. Section 1 focuses on the relevance of this guidance in the context of the broader risk assessment paradigm and other initiatives of the International Programme on Chemical Safety (IPCS) project on the Harmonization of Approaches to the Assessment of Risk from Exposure to Chemicals. Technical background material is presented in section 2 followed by generic guidan

Chemicals -- Physiological effect. --- Hazardous substances -- Risk assessment. --- Health risk assessment. --- No-Observed-Adverse-Effect Level -- Guideline. --- Pharmacokinetics. --- Risk Assessment -- standards -- Guideline. --- Species Specificity -- Guideline. --- Toxicology. --- Variation (Genetics) -- Guideline. --- Biological Phenomena --- Toxicity Tests --- Risk --- Risk Management --- Epidemiologic Measurements --- Genetic Phenomena --- Pharmacological Phenomena --- Organization and Administration --- Investigative Techniques --- Physiological Phenomena --- Probability --- Phenomena and Processes --- Public Health --- Health Services Administration --- Environment and Public Health --- Statistics as Topic --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Health Care Evaluation Mechanisms --- Delivery of Health Care. --- Epidemiologic Methods --- Quality of Health Care --- Health Care Quality, Access, and Evaluation --- No-Observed-Adverse-Effect Level --- Genetic Variation --- Risk Assessment --- Species Specificity