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Post Genomic Perspectives in Modeling and Control of Breathing is comprised of the proceedings of the IXth Oxford Conference on Modeling and Control of Breathing, held September 13-16, 2003 in Paris, France. This publication is placed within the general framework of post-genomic neurobiology, pathology, and the precise example of the rhythmic respiratory neural assembly being used to understand how genetic networks have been selected and conserved in the vertebrate brain. Specific topics include: ion channels and synapses responsible for respiratory rhythmogenesis and plasticity; pre- and post-natal development of the respiratory rhythm; chemosensory transduction and chemo-afferent signalling. These valuable insights open new avenues as to why the genetic codes underlying a vital function such as breathing have been selected, conserved, or optimized during evolution – a major issue of post-genomic biology. This critical issue will be considered from both top-down and bottom-up integrative modeling standpoints, with a view to elucidating the functional genomics linking discrete molecules to the integrated system that regulates breathing.
Respiration --- Regulation --- Respiration -- Regulation -- Congresses. --- Respiratory Mechanics -- genetics -- Congresses. --- Respiratory Mechanics -- physiology -- Congresses. --- Respiratory Mechanics --- Respiratory Physiological Processes --- Respiratory Physiological Phenomena --- Medicine. --- Neurosciences. --- Pathology. --- Biomedicine. --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine --- Medicine, Preventive --- Neural sciences --- Neurological sciences --- Neuroscience --- Nervous system --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians
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Rapid advances in molecular medicine have led to pronounced new developments in experimental and clinical cardiology. In the embrace of modern molecular biology and bridging the gap between the clinical and the genomic, cardiovascular medicine has seen major strides in the understanding of the molecular mechanisms that drive disease progression. The ability to rapidly identify candidate human genes for cardiovascular diseases lends itself to the development of diverse strategies for disease treatment and management. The wide variety of gene expressions proffers excellent targets for novel therapeutics. Gene therapy is steadily increasing in viability and represents a fascinating arena of research and clinical focus. This book is based on two international Mendel symposia on “Genes and the Heart,” joint meetings of the Japanese and European sections of the International Academy of Cardiovascular Sciences. Highlighting selected symposia contributions, this book explores the role of molecular biology and genetics in the basic knowledge, genesis, and clinical interventions of cardiovascular diseases.
Respiration -- Regulation -- Congresses. --- Respiration -- Regulation. --- Cardiovascular system --- Diseases --- Biology --- Biological Science Disciplines --- Natural Science Disciplines --- Disciplines and Occupations --- Genetics --- Cardiovascular Diseases --- Medicine --- Health & Biological Sciences --- Genetic aspects --- Heart --- Diseases. --- Cardiac diseases --- Heart diseases --- Medicine. --- Cardiology. --- Medical biochemistry. --- Medicine & Public Health. --- Medical Biochemistry. --- Cardiology --- Biochemistry. --- Internal medicine --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Composition --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology
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Breathing is performed by the rhythmic contraction of respiratory muscles. It ma- tains homeostasis of the organism by taking in the oxygen necessary to live and work and by controlling the level of CO within the organism. At first glance, breathing 2 seems simple; however, it is produced by a complex system in the brain with various afferents and efferents. The control of breathing is of the utmost importance in s- taining life, and although more than 150 years have passed since research on brea- ing control was first begun, many unsolved mysteries still remain. Breathing is like watching the tides at a beach that are created by the vast, complex open sea. The first Oxford Conference on Modeling and Control of Breathing was held 30 years ago in September of 1978 at the University Laboratory of Physiology in Oxford, England. During this first conference, the participants engaged in a hot d- cussion on the problem of whether breathing rhythm was produced by pacemaker cells or a neural network. This was before the discovery of the Bötinger complex in the medulla, and at the time, central chemoreceptive areas were still the focus of research. This conference was an especially unforgettable moment in the dawning of the new age of respiratory research. It has since been held every 3 years in various countries around the globe and is widely appreciated as the best respiratory meeting in the world.
Models, Biological -- Congresses. --- Respiration -- Regulation -- Congresses. --- Respiratory Physiological Phenomena -- Congresses. --- Sleep apnea syndromes -- Congresses. --- Respiration --- Sleep apnea syndromes --- Congresses --- Sleep Apnea Syndromes --- Models, Biological --- Respiratory Physiological Phenomena --- Sleep Disorders, Intrinsic --- Circulatory and Respiratory Physiological Phenomena --- Apnea --- Publication Formats --- Models, Theoretical --- Investigative Techniques --- Publication Characteristics --- Phenomena and Processes --- Dyssomnias --- Respiration Disorders --- Respiratory Tract Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Sleep Disorders --- Diseases --- Nervous System Diseases --- Neurology --- Physiology --- Medicine --- Human Anatomy & Physiology --- Health & Biological Sciences --- Regulation --- Medicine. --- Human physiology. --- Neurosciences. --- Neurobiology. --- Biomedicine. --- Human Physiology. --- Neurosciences --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Human biology --- Human body --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Tokio --- Breathing --- Oxford
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Our societies obviously rest on common beliefs. These "myths" are tools that help us to develop and build common identities; they form the structure around which societies function. This does not imply that these beliefs are “true,” in the sense that they would be supported by empirical facts. In social matters, myths have undoubtedly important functions to play even if no empirical facts support them. On the other hand, and precisely because they are not discussed, myths may be problematic: they may create illusions, conserve structures that are inefficient and unable to improve the situation of citizens. This is particularly true with constitutions. Constitutions are very important for societies: a constitution is a document — even in societies based on “unwritten” constitutions — which binds citizens together, creating unity among them, and which forms the framework within which our activities take place. As Nobel Prize laureate James Buchanan used to say, "Constitutions contain the rules of the social game we play in our everyday life." However, constitutions are not frequently debated by citizens. This is why we end up with common beliefs about these constitutions: they are above our heads, around us. We take them, their role, function, and nature as given. The purpose of this volume to investigate and challenge common constitutional myths. Featuring contributions from prominent economists, political scientists, and legal scholars, the chapters in this volume address such myths as “constitutions are binding social contracts,” “constitutions are economic documents” and “constitutions are legal documents.” Illustrating their analyses with historical and contemporary examples from the United States, Canada, and Europe, the authors build a multi-layered approach to understanding constitutions and their implications for social and political influence.
Respiration -- Regulation -- Congresses. --- Respiration -- Regulation -- Mathematical models -- Congresses. --- Respiration -- Regulation -- Mathematical models. --- Constitutional law --- Political psychology --- Political participation --- Law, Politics & Government --- Political Science --- Law, General & Comparative --- Political Science - General --- Constitutional law. --- Political psychology. --- Mass political behavior --- Political behavior --- Political science --- Politics, Practical --- Psychology, Political --- Constitutional limitations --- Constitutionalism --- Constitutions --- Limitations, Constitutional --- Psychological aspects --- Interpretation and construction --- Political science. --- Political philosophy. --- Economic policy. --- Political Science and International Relations. --- Political Science. --- Political Philosophy. --- Economic Policy. --- Constitutional Law. --- Public law --- Administrative law --- Psychology --- Social psychology --- Philosophy. --- Economic nationalism --- Economic planning --- National planning --- State planning --- Economics --- Planning --- National security --- Social policy --- Administration --- Civil government --- Commonwealth, The --- Government --- Political theory --- Political thought --- Politics --- Science, Political --- Social sciences --- State, The --- Political philosophy
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