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This book provides a collection of in-depth reviews broadly related to the mechanisms of viral replication as applied to various viruses of critical relevance for human or animal disease. Specifically, this book contains six different chapters: 1) Influenza A Virus Multiplication and the Cellular SUMOylation System; 2) West Nile Virus: Basic Principles, Replication Mechanism, Immune Response and Important Genetic Determinants of Virulence; 3) Hepatitis B Virus Genetic Diversity: Disease Pathogenesis; 4) An Overview of the Immune Evasion Strategies Adopted by Different Viruses With Special Reference to Classical Swine Fever Virus; 5) Viral Replication Strategies: Manipulation of ER Stress Response Pathways and Promotion of IRES-Dependent Translation; 6) Antiviral Replication Agents. This book is aimed at students, scholars, professors, and investigators who are peripherally related to, or somehow intrigued by, the different areas of virology covered in this book, as well as at those individuals with greater expertise and knowledge in the topics herein presented who may want up-to-date in depth reviews related to such topics.
Viruses --- Reproduction. --- Replication of viruses --- Viral replication --- Reproduction --- Medical microbiology & virology
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This book addresses the innovative themes in characterizing the cellular membrane platforms and intracellular networking, as well as the architectural aspects of cell compartments mediated by the entry and replication cycles of viruses. The instrumentation of modern molecular and cellular biology provides a potent array of wave packets to image, detect and manipulate major dynamics of macromolecular and subviral assemblies as in the host cellular context. The book includes case studies presented with highly coherent and structured illuminations, including microscopy, spectroscopy and scannin
Viruses --- Molecular structure. --- Structure, Molecular --- Chemical structure --- Structural bioinformatics --- Replication of viruses --- Viral replication --- Reproduction --- Reproduction.
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DNA viruses. --- Host-virus relationships. --- Pathology, Cellular. --- Viruses --- Reproduction. --- Cells --- Replication of viruses --- Viral replication --- Reproduction --- Cellular pathology --- Cytopathology --- Pathology --- Cytodiagnosis --- Relationships, Host-virus --- Virus-host relationships --- Host-parasite relationships --- pathology. --- pathogenicity. --- Host-virus relationships --- Pathology, Cellular --- pathology --- pathogenicity
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Viral Genome Packaging focuses on the process of genome "packaging" within a pre-formed viral procapsid. The chapters of this book concentrate on the biochemistry, enzymology and structural aspects of the genome packaging machinery. This book defines a broad mechanistic basis for the process across the prokaryotic and eukaryotic border, and for DNA and RNA viruses. The biochemical, biophysical and structural aspects of genome packaging are examined in detail.
Viruses --- Viral genetics. --- Reproduction. --- Virus genetics --- Microbial genetics --- Replication of viruses --- Viral replication --- Reproduction --- Genetics --- Medical virology. --- Biochemistry. --- Microbial genetics. --- Microbial genomics. --- Virology. --- Biochemistry, general. --- Biological and Medical Physics, Biophysics. --- Microbial Genetics and Genomics. --- Microorganisms --- Microbiology --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Genomics --- Medical microbiology --- Virology --- Virus diseases --- Composition --- Biophysics. --- Biological physics. --- Biological physics --- Physics
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Retroviruses --- Retrovirussen --- Rétrovirus --- Retroviridae --- Virus Replication --- Physiology --- Virus Replication. --- Physiology. --- Retroviruses. --- Viruses --- Replication, Virus --- Replications, Virus --- Virus Replications --- DNA Replication --- Replication of viruses --- Viral replication --- Reproduction --- C-type RNA viruses --- Leukemogenic viruses --- Leukoviruses --- Oncornaviruses --- Oncoviruses --- RNA tumor viruses --- Oncogenic viruses --- RNA viruses --- Reproduction. --- physiology. --- Viral Replication --- Replication, Viral --- Replications, Viral --- Viral Replications --- Viral Replication Compartments --- physiology
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Non enveloped viruses constitute an important class of medically significant pathogens. They encode their proteins in single (ss) and double strand (ds) RNA and DNA genomes and display a variety of sizes and structures. In this volume experts in the field provide up to date descriptions of many characteristics associated with the ssRNA noda, picorna and calciviruses, the dsRNA reo and rotaviruses, the ssDNA parvoviruses and the dsDNA polyoma and adenoviruses. While many aspects of these viruses have been addressed previously, this volume specifically focuses on the issue of their entry into cells, with particular attention to the translocation of the viral genome through a membrane, without the aid of inter-membrane fusion that is common and reasonably well understood in enveloped viruses. Sufficient detail has been revealed in most of the viruses discussed in this volume to establish a credible argument for convergent evolution. A variety of mechanisms are described to generate and tightly control the exposure of a fusion-like peptide or an entire gene product that facilitates membrane permeation and genome delivery into the cytoplasm and, for the DNA viruses, the nucleus. Since there is no viral membrane to fuse with the cellular membrane, the events at this interface are different from those associated with enveloped viruses and with the various fusion events associated with normal cellular function. Thus, while the factors critical for this process to occur have been well established for many of these viruses, a specific mechanism for genome penetration is yet to be determined. We believe that this volume will provide a reference of enduring value for the non enveloped virus field and our hope is that the focus on entry and genome translocation across a cellular membrane will stimulate new ideas and mechanistic studies of this critically important process.
Virus diseases -- Pathophysiology. --- Viruses -- Morphology. --- Viruses -- Physiology. --- Virus diseases --- Viruses --- Vertebrate Viruses --- Virus Diseases --- Organisms --- Diseases --- DNA Viruses --- RNA Virus Infections --- Biology --- Medicine --- Health & Biological Sciences --- Infectious Diseases --- Microbiology & Immunology --- Pathophysiology --- Physiology --- Morphology --- Viruses. --- Viral contamination. --- Reproduction. --- Replication of viruses --- Viral replication --- Medicine. --- Immunology. --- Virology. --- Biomedicine. --- Microbiology --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- Reproduction --- Microbial contamination --- Genetic vectors --- Microorganisms --- Mobile genetic elements --- Extrachromosomal DNA --- Medical virology. --- Medical microbiology --- Virology
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Currently, there is no single source that permits comparison of the factors, elements, enzymes and/or mechanisms employed by different classes of viruses for genome replication. As a result, we (and our students) often restrict our focus to our particular system, missing out on the opportunity to define unifying themes in viral genome replication or benefit from the advances in other systems. For example, extraordinary biological and experimental paradigms that have been established over the past five years for the DNA replication systems of bacteriophage T4 and T7 will likely be of great value to anyone interested in studying a replisome from any virus. These studies could easily go unnoticed by animal RNA and DNA virologists. It is our hope that this monograph will cross-fertilize and invigorate the field, as well as encourage students into this area of research.
Viral genomes. --- Viruses --Reproduction. --- Viral genomes --- Viruses --- Virus Replication --- Genetics --- Genome, Viral --- Virus Physiological Processes --- Biology --- Genome --- Microbiological Processes --- Virus Physiological Phenomena --- Biological Science Disciplines --- Genetic Structures --- Microbiological Phenomena --- Genetic Phenomena --- Natural Science Disciplines --- Disciplines and Occupations --- Phenomena and Processes --- Microbiology & Immunology --- Health & Biological Sciences --- Reproduction --- Reproduction. --- Replication of viruses --- Viral replication --- Viral genome --- Virus genomes --- Medicine. --- Human genetics. --- Immunology. --- Virology. --- Biochemistry. --- Cell biology. --- Microbiology. --- Biomedicine. --- Cell Biology. --- Biochemistry, general. --- Human Genetics. --- Microbial genomes --- Medical virology. --- Cytology. --- Heredity, Human --- Human biology --- Physical anthropology --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Immunobiology --- Life sciences --- Serology --- Microbial biology --- Microorganisms --- Medical microbiology --- Virology --- Virus diseases --- Composition --- Microbiology
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