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Tandem repeat polymorphisms : genetic plasticity, neural diversity, and disease
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ISBN: 1461454336 1461454344 Year: 2012 Volume: v. 769 Publisher: New York : Austin, Tex. : Springer Science+Business Media ; Landes Bioscience,

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Abstract

This book addresses the role of tandem repeat polymorphisms (TRPs) in genetic plasticity, evolution, development, biological processes, neural diversity, brain function, dysfunction and disease. There are hundreds of thousands of unique tandem repeats in the human genome and their polymorphic distributions have the potential to greatly influence functional diversity and disease susceptibility. Recent discoveries in this expanding field are critically reviewed and discussed in a range of subsequent chapters, with a focus on the role of TRPs and their various gene products in evolution, development, diverse molecular and cellular processes, brain function and disease.

Keywords

Biology. --- Medicine. --- Mutation (Biology). --- Repetitive Sequences, Nucleic Acid --- Genetic Variation --- Genetic Diseases, Inborn --- Neurodegenerative Diseases --- Genome Components --- Biology --- Biological Science Disciplines --- Nervous System Diseases --- Congenital, Hereditary, and Neonatal Diseases and Abnormalities --- Base Sequence --- Genetic Phenomena --- Genome --- Molecular Structure --- Genetic Structures --- Phenomena and Processes --- Diseases --- Natural Science Disciplines --- Disciplines and Occupations --- Biochemical Phenomena --- Chemical Phenomena --- Tandem Repeat Sequences --- Heredodegenerative Disorders, Nervous System --- Polymorphism, Genetic --- Genetics --- Mutation --- Health & Biological Sciences --- Genetic polymorphisms. --- Mutation (Biology) --- Polymorphisms, Genetic --- Medical genetics. --- Neurosciences. --- Biomedicine. --- Biomedicine general. --- Gene Function. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Clinical genetics --- Heredity of disease --- Human genetics --- Pathology --- Genetic disorders --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Physicians --- Genetic aspects --- Variation (Biology) --- Population genetics --- Health Workforce --- Biomedicine, general. --- genetics --- Mutations --- DNA Damage --- Polymorphism, Restriction Fragment Length --- Direct Tandem Repeats --- Tandem Repeat --- Tandem Repeats --- Direct Tandem Repeat --- Repeat Sequence, Tandem --- Repeat Sequences, Tandem --- Repeat, Direct Tandem --- Repeat, Tandem --- Repeats, Direct Tandem --- Repeats, Tandem --- Sequence, Tandem Repeat --- Sequences, Tandem Repeat --- Tandem Repeat Sequence --- Tandem Repeat, Direct --- Tandem Repeats, Direct --- DNA, Concatenated --- Genetic Polymorphisms --- Gene Polymorphism --- Genetic Polymorphism --- Polymorphism (Genetics) --- Gene Polymorphisms --- Polymorphism, Gene --- Polymorphisms (Genetics) --- Polymorphisms, Gene

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