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DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment. Experts on DNA repair proteins from all areas of cancer biology research take readers from bench research to new therapeutic approaches. This book provides a detailed discussion of combination therapies, in other words, how the inhibition of repair pathways can be coupled with chemotherapy, radiation, or DNA damaging drugs. Newer areas in this edition include the role of DNA repair in chemotherapy induced peripheral neuropathy, radiation DNA damage, Fanconi anemia cross-link repair, translesion DNA polymerases, BRCA1-BRCA2 pathway for HR and synthetic lethality, and mechanisms of resistance to clinical PARP inhibitors.

DNA repair. --- Cancer --- Treatment. --- DNA Repair. --- Neoplasms --- Gene therapy. --- therapy. --- Cancer therapy --- Cancer treatment --- Base Excision Repair --- Excision Repair --- Nucleotide Excision Repair --- Base Excision Repairs --- Excision Repair, Base --- Excision Repair, Nucleotide --- Excision Repairs --- Nucleotide Excision Repairs --- Repair, Base Excision --- Repair, Excision --- Repairs, Base Excision --- DNA-Formamidopyrimidine Glycosylase --- DNA Repair Enzymes --- Targeted Gene Repair --- Therapy

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Mutation (Biology) --- DNA repair --- Mutation --- DNA Repair --- Mutation (Biologie) --- ADN --- Réparation --- Base Excision Repair --- Excision Repair --- Nucleotide Excision Repair --- Base Excision Repairs --- Excision Repair, Base --- Excision Repair, Nucleotide --- Excision Repairs --- Nucleotide Excision Repairs --- Repair, Base Excision --- Repair, Excision --- Repairs, Base Excision --- Mutations --- Deoxyribonucleic acid repair --- Repair, DNA --- Repair mechanisms in DNA --- DNA-Formamidopyrimidine Glycosylase --- DNA Repair Enzymes --- Targeted Gene Repair --- DNA Damage --- Polymorphism, Restriction Fragment Length --- Biochemical genetics --- Antimutagens --- Genetics --- Variation (Biology) --- Mutation. --- DNA Repair.

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Molecular biology --- DNA Repair --- Deoxyribonucleic acid repair --- ADN --- DNA --- DNA Repair. --- DNA repair --- Repair, DNA --- Repair mechanisms in DNA --- Biochemical genetics --- Antimutagens --- Base Excision Repair --- Excision Repair --- Nucleotide Excision Repair --- Base Excision Repairs --- Excision Repair, Base --- Excision Repair, Nucleotide --- Excision Repairs --- Nucleotide Excision Repairs --- Repair, Base Excision --- Repair, Excision --- Repairs, Base Excision --- DNA-Formamidopyrimidine Glycosylase --- DNA Repair Enzymes --- Targeted Gene Repair --- DNA repair. --- DNA. --- Reparation de l'adn

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Molecular biology --- DNA Repair. --- DNA repair --- -577.217 --- Deoxyribonucleic acid repair --- Repair, DNA --- Repair mechanisms in DNA --- Biochemical genetics --- Antimutagens --- Base Excision Repair --- Excision Repair --- Nucleotide Excision Repair --- Base Excision Repairs --- Excision Repair, Base --- Excision Repair, Nucleotide --- Excision Repairs --- Nucleotide Excision Repairs --- Repair, Base Excision --- Repair, Excision --- Repairs, Base Excision --- DNA-Formamidopyrimidine Glycosylase --- DNA Repair Enzymes --- Targeted Gene Repair --- Congresses --- Realization of inheritance information. Translation. Molecular mechanisms of protein biosynthesis --- Congresses. --- 577.217 Realization of inheritance information. Translation. Molecular mechanisms of protein biosynthesis --- DNA Repair --- 577.217

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genome editing --- crispr --- epigenome editing --- genome medicine --- gene therapy --- Gene editing --- Gene editing. --- Editing, Gene --- Editing, Genome --- Genome editing --- Genetic engineering --- Gene Editing --- Genome --- DNA Repair --- Base Excision Repair --- Excision Repair --- Nucleotide Excision Repair --- Base Excision Repairs --- Excision Repair, Base --- Excision Repair, Nucleotide --- Excision Repairs --- Nucleotide Excision Repairs --- Repair, Base Excision --- Repair, Excision --- Repairs, Base Excision --- DNA-Formamidopyrimidine Glycosylase --- DNA Repair Enzymes --- Targeted Gene Repair --- Genomes --- Genes --- Proteome --- Genome Editing --- CRISPR-Associated Protein 9 --- Mutagenesis, Site-Directed --- CRISPR-Cas Systems --- Base Editing --- Editing, Base --- Genome. --- DNA Repair.