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Regeneration, the homeostatic ability to maintain tissue structure in the face of normal cell turnover or loss of tissue damaged by trauma or disease, is an essential  developmental process that continues throughout life. As recently as a decade ago, any serious discussion of the possibility of regeneration becoming a practical medical tool in the near future had the air of science fiction or over-optimistic speculation. The term “regenerative medicine” was certainly on many lips but few actually expected to soon see it applied in a clinical setting. A tidal wave of discovery has changed that and investigating the cellular mechanisms of natural regeneration has become one of the hottest topics in developmental biology and biomedicine in general.   Many researchers entering the field find that the regeneration literature is still quite diffuse perhaps owing to the disparate biological systems that have been the object of study including hydra, planaria, newts, axolotls and more recently several mouse strains. The volume editors believe that an attempt to organize or systematize the literature is long overdue. In this volume, respected experts highlight the latest findings in vertebrate (including mammals) wound healing and regeneration. They present eleven reviews that cover a wide range of topics, from wound repair and its relationship to regeneration, through systems including lenticular, neural, and musculoskeletal tissues and limbs, to epigenetics and the role of the cell cycle. Nuclear reprogramming and cellular plasticity, which open the door for potential regenerative medical therapies for injury and degenerative disease, are recurring themes throughout the book. We are all now part of the regeneration revolution.

Developmental biology. --- Human genetics. --- Human physiology. --- Medicine. --- Neurosciences. --- Regeneration -- physiology. --- Regeneration (Biology). --- Regeneration (Biology) --- Biological Processes --- Biological Science Disciplines --- Biological Phenomena --- Natural Science Disciplines --- Phenomena and Processes --- Disciplines and Occupations --- Physiology --- Regeneration --- Human Anatomy & Physiology --- Health & Biological Sciences --- Regenerative medicine. --- Regenerative biology --- Regrowth (Biology) --- Tissue engineering. --- Biomedicine. --- Human Physiology. --- Human Genetics. --- Regenerative Medicine/Tissue Engineering. --- Developmental Biology. --- Medicine --- Development (Biology) --- Biology --- Growth --- Ontogeny --- Biomedical engineering --- Regenerative medicine --- Tissue culture --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Human biology --- Human body --- Genetics --- Heredity, Human --- Physical anthropology --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Developmental biology --- Autotomy --- Wound healing

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Mesenchymal Stem Cells or Multipotent Mesenchymal Stromal Cells (collectively referred to as MSCs) are currently being tested in a number of clinical trials for various diseases including graft-versus-host disease, Crohn’s disease, myocardial infarction, stroke, diabetes, cartilage defects, and many others. The increasing number of clinical trials globally indicates the likely therapeutic potential of this specialized adult stem cell.  Over the last decade, there has been tremendous progress towards understanding an MSC’s phenotype, expansion features in culture, differentiation ability and global gene and protein expression profiles.  Despite the enormous progress and data accrual at the molecular and cellular levels, several questions remain as to the utility of MSCs for clinical applications.    Mesenchymal Stem Cell Therapy is a comprehensive collection of information comprised of both basic and pre-clinical biological studies as well as current advances in clinical applications within the MSC therapy field.  This text is a resource for both the basic life science and cell therapy researchers and includes a spectrum of review chapters from top experts in the field discussing clinical scale culture, regulatory issues, genetic engineering, disease specific applications and others.

Cytology. --- Regeneration -- Physiology. --- Stem cells. --- Transplantation of organs, tissues, etc. --- Multipotent stem cells --- Culture Techniques --- Stem Cell Transplantation --- Investigative Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Cell Transplantation --- Clinical Laboratory Techniques --- Transplantation --- Surgical Procedures, Operative --- Mesenchymal Stem Cell Transplantation --- Tissue Engineering --- Methods --- Biology --- Health & Biological Sciences --- Cytology --- Therapeutic use --- Mesenchymal stem cells. --- Bone marrow stromal cells --- Marrow stromal cells --- MSCs (Mesenchymal stem cells) --- Stromal cells, Bone marrow --- Stromal cells, Marrow --- Life sciences. --- Cell biology. --- Life Sciences. --- Stem Cells. --- Cell Biology. --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Mesenchymal Stem Cells. --- Mesenchymal Stem Cell Transplantation. --- methods. --- Transplantation, Mesenchymal Stem Cell --- Stem Cell Transplantation, Mesenchymal --- Mesenchymal Stem Cells --- Adipose Tissue-Derived Mesenchymal Stem Cells --- Adipose Tissue-Derived Mesenchymal Stromal Cells --- Adipose-Derived Mesenchymal Stem Cells --- Adipose-Derived Mesenchymal Stromal Cells --- Bone Marrow Mesenchymal Stem Cells --- Bone Marrow Stromal Cell --- Bone Marrow Stromal Cells --- Bone Marrow Stromal Cells, Multipotent --- Bone Marrow Stromal Stem Cells --- Mesenchymal Progenitor Cell --- Mesenchymal Progenitor Cells --- Mesenchymal Stem Cell --- Mesenchymal Stem Cells, Adipose-Derived --- Mesenchymal Stromal Cells, Multipotent --- Multipotent Bone Marrow Stromal Cells --- Multipotent Mesenchymal Stromal Cells --- Stem Cells, Mesenchymal --- Wharton Jelly Cells --- Wharton's Jelly Cells --- Mesenchymal Stromal Cells --- Adipose Derived Mesenchymal Stem Cells --- Adipose Derived Mesenchymal Stromal Cells --- Adipose Tissue Derived Mesenchymal Stem Cells --- Adipose Tissue Derived Mesenchymal Stromal Cells --- Mesenchymal Stem Cells, Adipose Derived --- Mesenchymal Stromal Cell --- Progenitor Cell, Mesenchymal --- Progenitor Cells, Mesenchymal --- Stem Cell, Mesenchymal --- Stromal Cell, Mesenchymal --- Stromal Cells, Mesenchymal --- Wharton's Jelly Cell --- Whartons Jelly Cells --- transplantation --- Adipose Tissue-Derived Mesenchymal Stem Cell --- Adipose-Derived Mesenchymal Stem Cell --- Bone Marrow Mesenchymal Stem Cell --- Multipotent Bone Marrow Stromal Cell --- Multipotent Mesenchymal Stromal Cell --- Adipose Derived Mesenchymal Stem Cell --- Adipose Tissue Derived Mesenchymal Stem Cell