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This is the first comprehensive book exclusively dedicated to anorectal physiology and the importance of diagnostic tools in guiding the evaluation and treatment of anorectal dysfunction. Functional disorders, and specifically fecal incontinence and evacuatory disorders, are prevalent in the general population, affecting up to 20% of individuals. As many of these conditions have extremely complex mechanisms, a thorough understanding of anorectal physiology is a crucial element in the surgeon’s “arsenal" to ensure accurate evaluation and to inform treatment. At this time, there is no other title that specifically addresses all aspects of anorectal physiology, as well as anorectal and pelvic floor disorders, including fecal incontinence and defecation disorders. Specifically, the book provides detailed descriptions of diagnostic methods and treatment algorithms for a range of anorectal conditions, including modern treatment modalities such as sacral neuromodulation. A unique and comprehensive reference covering all aspects of the evaluation and treatment of anorectal disorders, Anorectal Physiology – A Clinical and Surgical Perspective will be of significant interest to proctologists and coloproctologists, gastroenterologists, colorectal surgeons, gynecologists and all other professionals interested in anorectal physiology. .

Proctology. --- Rectum—Surgery . --- Gynecology . --- Human physiology. --- Gastroenterology . --- Colorectal Surgery. --- Gynecology. --- Human Physiology. --- Gastroenterology. --- Internal medicine --- Digestive organs --- Human biology --- Medical sciences --- Physiology --- Human body --- Gynaecology --- Medicine --- Generative organs, Female --- Gastroenterology --- Diseases --- Rectum --- Anus --- Diseases. --- Surgery. --- Proctology --- Recte --- Fisiologia humana --- Malalties del còlon --- Cirurgia colorectal --- Proctologia --- Cirurgia de colon, recte i anus --- Cirurgia del tub digestiu baix --- Cirurgia enterorectoanal --- Cirurgia --- Colostomia --- Còlon --- Colopaties --- Malalties intestinals --- Colitis --- Síndrome de l'intestí irritable --- Biologia humana --- Ciències de la salut --- Fisiologia --- Mecànica humana --- Reproducció humana --- Cos humà --- Coloproctologia --- Gastroenterologia --- Malalties de l'anus --- Malalties del recte --- Colorecte --- Intestí gros --- Colon (Anatomy) --- Malalties del còlon.

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This second edition is an all-inclusive textbook with a unique algorithm-based approach to the evaluation and management of colorectal surgery disease. It examines the thought processes, technical tricks, and decision-making strategies for specific clinical situations. The book aims to utilise the experience its contributors have gained caring for patients with a wide range of colorectal diseases. The technical challenges of managing complex patients and the technical details that make these situations challenging are covered, and evidence and experience-based solutions are offered for surgeons of all levels. This book focuses on providing pragmatic advice and reproducible techniques that can be readily implemented by surgeons of varying experience to successfully treat complex colorectal problems through an algorithmic approach.

Rectum—Surgery . --- Colorectal Surgery. --- Colon (Anatomy) --- Surgery --- Decision making. --- Colorectum --- Intestine, Large --- Cirurgia colorectal --- Presa de decisions --- Decisions (Psicologia) --- Presa de decisió --- Teoria de la decisió --- Teoria de l'estimació --- Teoria de jocs --- Decisió de grup --- Dilema --- Estadística bayesiana --- Presa de decisions multicriteri --- Elecció (Psicologia) --- Òrgans consultius --- Resolució de problemes --- Cirurgia de colon, recte i anus --- Cirurgia del tub digestiu baix --- Cirurgia enterorectoanal --- Cirurgia --- Colostomia --- Anus --- Còlon --- Proctologia --- Recte

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The intestine is home to diverse bacterial communities forming the microbiome that influences host nutrition, immune functions and health. DNA-based methods have been instrumental to gain insight into the microbial eukaryotic diversity of the human gut. For instance, the microbiome share the intestinal ecosystem with a population of uni- and multi-cellular eukaryotic organisms. These eukaryotic organisms are very common and often very abundant in individuals with intestinal healthy conditions as well as those with intestinal diseases. The impact of the relationship between bacterial and eukaryotic organisms within the intestinal ecosystem on homeostasis and intestinal diseases is limited and can be considered an important emerging field of research. In addition, the factors that differentiate pathogenic eukaryotes from commensals are still unknown. Our interest focuses on the families of eukaryotic microbes inhabiting the intestine, called “intestinal eukaryome”, that include fungi, protists and helminths. All these organisms and their interplay with bacteria and the human immune system are a challenge to assess the impact (present and future) of intestinal infectious diseases on public health. This book presents an overview of the science presented and discussed in the First Eukaryome Congress, held from October 16th to 18th, 2019 at Pasteur Institute in Paris, France. This contributed volume is of special interest for PhD students, postdoctoral fellows, researchers and clinicians interested in the effect of the eukaryotic microbiome on human health.

Eukaryotic cells --- Medical microbiology. --- Parasitology. --- Microbiology. --- Molecular biology. --- Medical Microbiology. --- Eukaryotic Microbiology. --- Molecular Medicine. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Microbial biology --- Biology --- Microorganisms --- Protists --- Cèl·lules eucariotes --- Malalties intestinals --- Enteropatia --- Enteropaties --- Malalties dels intestins --- Malalties de l'aparell digestiu --- Diarrea --- Disenteria --- Malalties de l'anus --- Malalties del còlon --- Malalties del recte --- Obstrucció intestinal --- Restrenyiment --- Cèl·lules --- Cèl·lules animals --- Eucariotes --- Protists eucariotes --- Protozous --- Malalties intestinals.

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Rectum --- Diseases --- Surgery. --- Diseases. --- Human beings --- Illness --- Illnesses --- Morbidity --- Sickness --- Sicknesses --- Medicine --- Epidemiology --- Health --- Pathology --- Sick --- Proctology --- Anus --- Anorectal Malformations. --- Anus Diseases. --- Diagnosis --- Surgery --- abnormalities. --- Anus Disease --- Disease, Anus --- Diseases, Anus --- Anorectal Anomalies --- Anorectal Atresia --- Anorectal Malformation --- Anorectal Stenosis --- Anomalies, Anorectal --- Anomaly, Anorectal --- Anorectal Anomaly --- Anorectal Atresias --- Anorectal Stenoses --- Atresia, Anorectal --- Atresias, Anorectal --- Malformation, Anorectal --- Malformations, Anorectal --- Stenoses, Anorectal --- Stenosis, Anorectal --- Colorectum --- Cloaca (Zoology) --- Intestine, Large --- Anal sphincter --- Sphincters --- Malalties de l'anus --- Malalties del recte --- Cirurgia colorectal

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Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the second of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutics, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.

Cancer research. --- Immunology. --- Medicine. --- Cancer Research. --- Biomedicine, general. --- Health Workforce --- Immunobiology --- Life sciences --- Serology --- Cancer research --- Cancer --- Research. --- Colonic Neoplasms. --- Colorectal Neoplasms --- immunology. --- Cancer of the Colon --- Colon Neoplasms --- Colonic Cancer --- Neoplasms, Colonic --- Cancer of Colon --- Colon Cancer --- Cancer, Colon --- Cancer, Colonic --- Cancers, Colon --- Cancers, Colonic --- Colon Cancers --- Colon Neoplasm --- Colonic Cancers --- Colonic Neoplasm --- Neoplasm, Colon --- Neoplasm, Colonic --- Neoplasms, Colon --- Càncer colorectal --- Investigació mèdica --- Tractament adjuvant del càncer --- Immunologia --- Biologia --- Complements (Immunitat) --- Immunofarmacologia --- Immunologia clínica --- Immunologia de la trasplantació --- Neuroimmunologia --- Resposta immunitària --- Sistema immunitari --- Teràpia adjuvant del càncer --- Tractaments adjuvants del càncer --- Teràpies adjuvants del càncer --- Investigació biomèdica --- Investigació --- Investigació farmacèutica --- Experimentació humana en medicina --- Ressenyes sistemàtiques (Investigació mèdica) --- Animals de laboratori --- Càncer de còlon --- Càncer de recte --- Càncer gastrointestinal