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Tissue engineering. --- Biomedical engineering --- Regenerative medicine --- Tissue culture --- Enginyeria de teixits --- Enginyeria tisular --- Reconstrucció d'òrgans --- Reconstrucció de teixits --- Cultiu de teixits --- Enginyeria biomèdica --- Medicina regenerativa
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Tissue engineering and regenerative medicine is a new, interdisciplinary branch of science that combines knowledge from numerous scientific fields including biology, biochemistry, physics, chemistry, applied engineering, and medicine. It aims to restore damaged parts of the human body by rebuilding them in vitro using individual building blocks of biological tissues such as cells and the extracellular matrix that surrounds them. The authors hope to spark students’ interest in this exciting new field of science as well as give them a basic knowledge of its terminology. This book is based on a hands-on practical course in tissue engineering conducted by the Fulbright US Scholar recipient, Dr. Narine Sarvazyan (George Washington University, Washington USA). It provides an overview of the core topics of the tissue engineering field, including stem cell differentiation, the role of extracellular matrix and attachment proteins, scaffolds, and culturing of engineered tissues. Each chapter is accompanied by hands-on demonstrations and self-check questions. The text is easily readable for students of all backgrounds and the described protocols can be conducted using common lab equipment. This textbook is also useful for developing undergraduate and graduate courses that teach basic methods and approaches in this promising and rapidly developing field. .
Biomedical engineering. --- Regenerative medicine. --- Tissue engineering. --- Biomedical Engineering/Biotechnology. --- Regenerative Medicine/Tissue Engineering. --- Biomedical engineering --- Regenerative medicine --- Tissue culture --- Medicine --- Regeneration (Biology) --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Enginyeria de teixits --- Medicina regenerativa --- Medicina --- Regeneració (Biologia) --- Enginyeria tisular --- Reconstrucció d'òrgans --- Reconstrucció de teixits --- Cultiu de teixits --- Enginyeria biomèdica
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Cardiovascular diseases are still the leading cause of death in developed countries. Revascularization procedures such as coronary artery and peripheral bypass grafts, as well as access surgery represent a 2$ billion market yearly for the US alone. Despite intense research over many decades, no clinically suitable, shelf-ready, synthetic, vascular, small-caliber graft exists. There is therefore still a quest for such a clinical vascular prosthesis for surgical revascularization procedures and access surgery. Many approaches have been tried and are currently under investigation with promising results. These range from acellular and cell-based, stable or bio-degradable, synthetic scaffolds to biological or decellularized grafts, not forgetting self-assembly technologies for in vitro or in vivo VTE. All these approaches can be further enhanced by functionalization, e.g. with growth factors and drug elution. This updatable book aims to cover all the relevant aspects of Vascular Tissue Engineering (VTE) and novel alternatives to develop vascular grafts for clinical applications. The chapters in this book cover different aspects of manufacturing scaffolds with various polymers, mechanical characteristics, degradation rates, decellularization techniques, cell sheet assembly, 3-D printing and autologous mandril-based VTE. All the necessary in vitro tests such as biocompatibility and thrombogenicity are reviewed. Pre-clinical assessment of in vivo experimental models include patency, compliance, intimal hyperplasia, inflammatory reaction, cellular ingrowth and remodeling. Finally, early clinical trials will be periodically updated regarding results, regulatory aspects and post-marketing quality assessment. Furthermore, the reader should get an insight into various approaches, technologies and methods to better understand the complexity of blood surface and cell interactions in VTE. Translational research has yielded early human applications clearly showing the enormous need of research in the field to provide better solutions for our patients and this continuously updated book will hopefully become a reference in the field for life sciences.
Regenerative medicine. --- Tissue engineering. --- Biomedical engineering. --- Surgery. --- Biomaterials. --- Regenerative Medicine/Tissue Engineering. --- Biomedical Engineering and Bioengineering. --- Surgery, Primitive --- Medicine --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Biomedical engineering --- Regenerative medicine --- Tissue culture --- Regeneration (Biology) --- Biocompatible materials --- Biomaterials --- Medical materials --- Materials --- Biocompatibility --- Prosthesis --- Vascular grafts. --- Blood-vessels --- Transplantation of organs, tissues, etc. --- Grafts --- Transplantation --- Bioartificial materials --- Hemocompatible materials --- Biomaterials (Biomedical materials) --- Biomedical materials. --- Enginyeria de teixits --- Medicina regenerativa --- Medicina --- Regeneració (Biologia) --- Enginyeria tisular --- Reconstrucció d'òrgans --- Reconstrucció de teixits --- Cultiu de teixits --- Enginyeria biomèdica
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Biomedical materials. --- Tissue engineering. --- Regenerative medicine. --- Medicine --- Regeneration (Biology) --- Biomedical engineering --- Regenerative medicine --- Tissue culture --- Bioartificial materials --- Biocompatible materials --- Biomaterials (Biomedical materials) --- Hemocompatible materials --- Medical materials --- Materials --- Biocompatibility --- Prosthesis --- Enginyeria de teixits --- Materials biomèdics --- Medicina regenerativa --- Medicina --- Regeneració (Biologia) --- Biomaterials --- Materials biocompatibles --- Materials mèdics --- Materials en medicina --- Enginyeria biomèdica --- Biocompatibilitat --- Col·loides en medicina --- Materials dentals --- Polímers en medicina --- Pròtesis --- Enginyeria tisular --- Reconstrucció d'òrgans --- Reconstrucció de teixits --- Cultiu de teixits
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Biomedical materials. --- Regenerative medicine. --- Tissue engineering. --- Biomedical engineering --- Regenerative medicine --- Tissue culture --- Medicine --- Regeneration (Biology) --- Bioartificial materials --- Biocompatible materials --- Biomaterials (Biomedical materials) --- Hemocompatible materials --- Medical materials --- Materials --- Biocompatibility --- Prosthesis --- Materials biomèdics --- Medicina regenerativa --- Enginyeria de teixits --- Enginyeria tisular --- Reconstrucció d'òrgans --- Reconstrucció de teixits --- Cultiu de teixits --- Enginyeria biomèdica --- Medicina --- Regeneració (Biologia) --- Biomaterials --- Materials biocompatibles --- Materials mèdics --- Materials en medicina --- Biocompatibilitat --- Col·loides en medicina --- Materials dentals --- Polímers en medicina --- Pròtesis
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This volume explores multiple methods and approaches used to generate human brain and neuroretinal organoids to address fundamental questions in human brain research. The chapters in this book cover topics such as self-organizing brain organoids with ventricles amenable to injection and electroporation; visualization of 3D organoids though the latest advancements in microscopy; generation of 3D retinal tissue with physiologically competent, light-sensitive photoreceptors; modeling brain tumors using genetically edited brain organoids; and brain organoids as a model to study Zika virus and SARS-CoV-2 infections. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Comprehensive and cutting-edge, Brain Organoid Research is a valuable resource for researchers at various levels of learning, ranging from undergraduate students, early researchers, and advanced laboratories. This book aims to be instrumental in moving this developing field forward.
Neurosciences. --- Neuroscience. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Cervell --- Enginyeria de teixits --- Cèl·lules mare --- Cèl·lules --- Cèl·lules mare embrionàries --- Enginyeria tisular --- Reconstrucció d'òrgans --- Reconstrucció de teixits --- Cultiu de teixits --- Enginyeria biomèdica --- Medicina regenerativa --- Cap --- Craniologia --- Encèfal --- Sistema nerviós central --- Bulb raquidi --- Cerebel --- Escorça cerebral --- Evolució del cervell --- Frenologia --- Hipòfisi --- Líquid cefalorraquidi --- Memòria --- Neurones motores --- Neuropsicologia --- Neuropsiquiatria --- Psicologia --- Sistema límbic --- Somnis --- Son --- Tàlem (Anatomia) --- Tronc de l'encèfal --- Cirurgia cerebral
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Tissue engineering --- Tissue culture --- Génie tissulaire --- Tissus (Histologie) --- Periodicals --- Périodiques --- Culture --- Tissue Engineering. --- Tissue engineering. --- Engineering, Tissue --- stem cells --- progenitor cells --- Histology. --- Biological Engineering. --- Tissues --- Tissues. --- Biomedical engineering --- Regenerative medicine --- Histology --- Organs (Anatomy) --- Organ Culture Techniques --- Tissue Expansion --- Regenerative Medicine --- Guided Tissue Regeneration --- Cell- and Tissue-Based Therapy --- General biochemistry --- Medicina regenerativa. --- Enginyeria de teixits --- Enginyeria biomèdica. --- Enginyeria clínica --- Enginyeria mèdica --- Bioenginyeria --- Biofísica --- Enginyeria --- Medicina --- Electrònica mèdica --- Materials biomèdics --- Aparells i instruments mèdics --- Enginyeria tisular --- Reconstrucció d'òrgans --- Reconstrucció de teixits --- Cultiu de teixits --- Enginyeria biomèdica --- Medicina regenerativa --- Regeneració (Biologia) --- Microphysiological Systems
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This book is the first of two volumes that together offer a comprehensive account of cutting-edge advances in the development of biomaterials for use within tissue engineering and regenerative medicine. Topics addressed in this volume, which is devoted to bioinspired biomaterials, range from novel biomaterials for regenerative medicine through to emerging enabling technologies with applications in, for example, drug delivery, maternal–fetal medicine, peripheral nerve repair and regeneration, and brain tumor therapy. New bioinspired hydrogels receive detailed attention in the book, and a further focus is the use of bioinspired biomaterials in the regulation of stem cell fate. Here the coverage includes the role of scaffolds in cartilage regeneration, the bioapplication of inorganic nanomaterials in tissue engineering, and guidance of cell migration to improve tissue regeneration. The authors are recognized experts in the interdisciplinary field of regenerative medicine and the book will be of value for all with an interest in regenerative medicine based on biomaterials. .
Biomedical materials. --- Biocompatible materials --- Biomaterials --- Medical materials --- Medicine --- Biomedical engineering --- Materials --- Biocompatibility --- Prosthesis --- Biomedical engineering. --- Regenerative medicine. --- Tissue engineering. --- Pharmaceutical technology. --- Neurosciences. --- Biochemical engineering. --- Biomedical Engineering/Biotechnology. --- Regenerative Medicine/Tissue Engineering. --- Pharmaceutical Sciences/Technology. --- Biochemical Engineering. --- Bio-process engineering --- Bioprocess engineering --- Biochemistry --- Biotechnology --- Chemical engineering --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Regenerative medicine --- Tissue culture --- Regeneration (Biology) --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Materials biomèdics --- Enginyeria de teixits --- Medicina regenerativa --- Medicina --- Regeneració (Biologia) --- Enginyeria tisular --- Reconstrucció d'òrgans --- Reconstrucció de teixits --- Cultiu de teixits --- Enginyeria biomèdica --- Materials biocompatibles --- Materials mèdics --- Materials en medicina --- Biocompatibilitat --- Col·loides en medicina --- Materials dentals --- Polímers en medicina --- Pròtesis
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