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Since their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson's disease, multiple sclerosis, Alzheimer's disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of intense investigations into understanding the molecular structures and pharmacology of these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials. These molecules will define the next new classes of drugs for a number of diseases with unmet medical needs.

Adenosine --- Adenosinrezeptor --- Pharmacokinetics. --- Purinergic P1 Receptor Antagonists. --- Receptors, Purinergic P1 --- Receptors. --- Pathophysiologie --- Physiologie --- therapeutic use.

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This Book "A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics " documents the present state of knowledge of the adenosine A3 receptor. Adenosine A3 receptors are G protein-linked receptors that function in physiology and intracellular signaling and are involved in inflammatory responses and mediating cell proliferation and cell death. The A3 receptor is increasingly being recognized for its biological roles throughout the body, and many A3 receptor ligands have proven useful in elucidating peripheral and central pathologies. This book covers a wide range of information including data from studies of theoretical, molecular and cellular pharmacology, signal transduction, integrative physiology, new drug discoveries and clinical applications. The book includes sections on: A3 Adenosine Receptor signal transduction Adenosine Receptor medicinal chemistry Effects and therapeutic applications of Adenosine Receptors on tissues and organs Adenosine Receptors and inflammatory and auto-immune diseases Adenosine Receptors and cancer The chapters in this book cover both fundamental science and relevant applications and provide an authoritative account of the current status of the field. "A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics" is an up to date and scientifically excellent source of information, attractive to basic and clinical scientists alike.

Biomedicine. --- Pharmacology/Toxicology. --- Medicinal Chemistry. --- Cardiology. --- Pneumology/Respiratory System. --- Medicine. --- Toxicology. --- Biochemistry. --- Pneumology. --- Médecine --- Toxicologie --- Biochimie --- Cardiologie --- Adenosine -- Physiological effect. --- Adenosine -- Receptors. --- Neural transmission -- Regulation. --- Adenosine --- Neural transmission --- Natural Science Disciplines --- Receptors, Purinergic P1 --- Receptor, Adenosine A3 --- Chemistry --- Disciplines and Occupations --- Receptors, Purinergic --- Receptors, Cell Surface --- Receptors, Neurotransmitter --- Receptors, G-Protein-Coupled --- Membrane Proteins --- Proteins --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Health & Biological Sciences --- Human Anatomy & Physiology --- Neuroscience --- Pharmacy, Therapeutics, & Pharmacology --- Animal Biochemistry --- Receptors --- Physiological effect --- Regulation --- Receptors. --- Physiological effect. --- Regulation. --- Regulation of neural transmission --- Adenocard --- Adenoscan --- Pharmacology. --- Medicinal chemistry. --- Respiratory organs --- Diseases. --- Biological control systems --- Purine nucleosides --- Ribonucleosides --- Heart --- Internal medicine --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Diseases --- Composition --- Toxicology --- Respiratory organs—Diseases. --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Drug effects --- Medical pharmacology --- Chemotherapy --- Pharmacy