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Brain --- Receptors, Opioid --- Oligopeptides --- Seizures --- metabolism --- physiology --- toxicity --- chemically induced

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Glucose --- Receptors, Opioid --- Tomography, Emission-Computed --- Epilepsy, Frontal Lobe --- metabolism --- radionuclide imaging

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Analgesics, Opioid --- Morphine Derivatives --- Analgesia --- Receptors, Opioid, mu --- Pain Threshold --- pharmacokinetics --- genetics --- drug effects

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Drug abuse --- Pain --- Receptors --- Receptors, opioid --- Substance abuse --- Substance related disorders, drug therapy --- Substance-related disorders --- Chemotherapy --- Drug therapy --- Opoid, agonists --- Agonists

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This volume describes our current understanding of the biological role of the delta-opioid receptor (DOR) system, focusing on its unique mechanisms of receptor trafficking and signaling in disease states. Part 1 covers the endogenous ligands that regulate the DOR system as well as novel compounds and therapies used to modulate the DOR system. Part 2 describes new insights into the localization and trafficking of the DOR and how ligand-directed signaling alters the fate of the receptor. Part 3 concentrates on the potential role of the DOR system in disease states, such as pain, mood, addiction, and Parkinson’s disease. Throughout the book, the DOR system as a target for drug development will be discussed.

Opioids --- Pharmacology, Experimental. --- Receptors, Opioid, delta --- Receptors. --- Effect of drugs on. --- Experimental pharmacology --- Therapeutics, Experimental --- Opioid receptors --- Toxicology. --- Neurosciences. --- Human physiology. --- Pharmacology/Toxicology. --- Human Physiology. --- Human biology --- Medical sciences --- Physiology --- Human body --- Neural sciences --- Neurological sciences --- Neuroscience --- Nervous system --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Pharmacology. --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect