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Nuclear receptors (Biochemistry) --- Nuclear hormone receptors --- Receptors, Nuclear (Biochemistry) --- Receptors, Nuclear hormone --- Hormone receptors --- Transcription factors

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Nuclear Receptors, second edition, is a comprehensive guide to studying members of the steroid and nuclear receptor superfamily of transcriptase factors. It provides useful information for biomedical and clinical researchers.

Steroid hormones --- Nuclear receptors (Biochemistry) --- Transcription factors. --- Genetic transcription factors --- Proteins --- Nuclear hormone receptors --- Receptors, Nuclear (Biochemistry) --- Receptors, Nuclear hormone --- Hormone receptors --- Transcription factors --- Receptors.

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Nuclear receptors (Biochemistry) --- Nuclear hormone receptors --- Receptors, Nuclear (Biochemistry) --- Receptors, Nuclear hormone --- Hormone receptors --- Transcription factors --- Receptors nuclears (Bioquímica) --- Receptors cel·lulars --- Factors de transcripció

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Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. The aim is to bring together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity. The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading to the regulation of target genes, often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors.

Biomedicine. --- Human Genetics. --- Endocrinology. --- Human Physiology. --- Medicine. --- Human genetics. --- Human physiology. --- Médecine --- Génétique humaine --- Physiologie humaine --- Endocrinologie --- ;. --- Pathology --- Genetics --- Medicine --- Biology --- Health & Biological Sciences --- Nuclear receptors (Biochemistry) --- Nuclear hormone receptors --- Receptors, Nuclear (Biochemistry) --- Receptors, Nuclear hormone --- Hormone receptors --- Transcription factors --- Human biology --- Medical sciences --- Physiology --- Human body --- Internal medicine --- Hormones --- Heredity, Human --- Physical anthropology --- Endocrinology .

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In 1890 a case of myxedema was treated in Lisbon by the implantation of a sheep thyroid gland with the immediate improvement in the patient’s condition. A few years later, medications for the then ill-explained condition of the menopause included tablets made from cow ovaries. In the first quarter of the 20th century the identification of vitamin D, and its sunlight driven production in skin, paved the way to the elimination of rickets as a major medical problem. Twenty years or so later, Sir Vincent Wigglesworth established the endocrine basis of developmental moulting in insects, arguably the most commonly performed animal behaviour on Planet Earth. A paradigm that would unify these disparate observations arose between 1985 and 1987 beginning with the identification of the glucocorticoid receptor and the nuclear receptor super-family. What follows is a timely and positive manifestation of the capacity, productivity and value of international human scientific endeavour. Based on intrigue, lively competition and cooperation a global effort has rapidly fostered a school of biology with widespread ramifications for the understanding of metazoan animals, the human condition and the state of the planet. This book is the first this century to try and capture the spirit of this endeavour, to depict where the field is now and to identify some of the challenges and opportunities for the future.

Nuclear receptors (Biochemistry). --- Nuclear receptors (Biochemistry) --- DNA-Binding Proteins --- Transcription Factors --- Cell Physiological Processes --- Proteins --- Receptors, Cytoplasmic and Nuclear --- Cell Communication --- Cell Physiological Phenomena --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Phenomena and Processes --- Biology --- Cytology --- Health & Biological Sciences --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Nuclear hormone receptors --- Receptors, Nuclear (Biochemistry) --- Receptors, Nuclear hormone --- Composition --- Medicine. --- Endocrinology. --- Oncology. --- Cell biology. --- Biomedicine. --- Biomedicine general. --- Cell Biology. --- Animal Biochemistry. --- Chemistry --- Medical sciences --- Hormone receptors --- Transcription factors