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Neurotransmitter Agents. --- Receptors, Neurotransmitter. --- Neuropeptides. --- Receptors, Neuropeptide. --- Signal Transduction --- Synaptic Transmission --- Neuropeptides. --- Neurotransmitters. --- Second messengers (Biochemistry) --- Neuropharmacology. --- Neuropeptides --- Neurotransmetteurs --- Seconds messagers (Biochimie) --- Neuropharmacologie --- physiology. --- physiology.

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Impairment of orexin/hypocretin signaling causes narcolepsy-cataplexy in animals and humans. Most human narcolepsy-cataplexy cases are associated with orexin/hypocretin ligand deficiency, which can be detected clinically using cerebrospinal orexin/hypocretin measures and may lead to future treatments with orexin/hypocretin replacement therapy. In The Orexin/Hypocretin System: Physiology and Pathophysiology, leading researchers and clinicians review these exciting developments to set the stage for further research on the loss of orexin/hypocretin neurons in humans, regulation of sleep and wakefulness by the orexin/hypocretin system, and the role of the orexin/hypocretin system in many other physiological processes, including feeding, autonomic regulation, and neuroendocrine regulation. Topics of interest include an assessment of the functions and the physiology of orexin/hypocretin, its pathophysiology in human narcolepsy-cataplexy, and possible pharmacological treatments. The authors also introduce several experimental methods for orexin/hypocretin research, and, using multidisciplinary approaches, explain their uses and limitations. Authoritative and state-of-the-art, The Orexin/Hypocretin System: Physiology and Pathophysiology will aid scientists in the search for novel bioactive peptides and their receptors, as well as novel physiological insights and opportunities for the clinical treatment of not only narcolepsy, but also a broad range of diseases associated with endocrine, feeding, and body weight regulation.

Narcolepsy. --- Orexins. --- Orexins --- Narcolepsy --- Disorders of Excessive Somnolence --- Peptides --- Receptors, Neurotransmitter --- Receptors, Peptide --- Nerve Tissue Proteins --- Receptors, Cell Surface --- Amino Acids, Peptides, and Proteins --- Proteins --- Sleep Disorders, Intrinsic --- Chemicals and Drugs --- Membrane Proteins --- Dyssomnias --- Sleep Disorders --- Nervous System Diseases --- Mental Disorders --- Diseases --- Psychiatry and Psychology --- Neuropeptides --- Receptors, Neuropeptide --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Neurology --- Animal Biochemistry --- Hypocretins --- Medicine. --- Neurosciences. --- Biomedicine. --- Sleep disorders --- Hypothalamic hormones

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In 1988, Gavril W. Pasternak published the first edition of this seminal text. It was a lucid account of the latest knowledge on opiate receptors and related receptor subtypes, a then controversial field, providing an integrated approach correlating the biochemical, physiological, and pharmacological aspects of opiate reaction. Fully revised and expanded, The Opiate Receptors, 2nd edition presents all the advances made in the field in the past twenty years. It covers a wide variety of topics including, but not limited to, the following: pharmacology of opioid drugs; endogenous opioids; molecular biology of mu receptors; molecular biology of delta receptors; kappa opioid receptor gene and the regulatory mechanisms of its protein expression; opioid receptor signal transduction mechanisms; mu opioid receptor mediated analgesia and reward; kappa opioid receptor function; delta opioid receptor function; genetics of opioid receptor functions in mice; opioid receptor trafficking; opioid receptor dimerization; molecular modulation of in vivo tolerance; and genetics of opioid actions. Written by leading international researchers in the field, this new edition is as groundbreaking and vital as its predecessor.

Endorphins -- Receptors. --- Endorphins. --- Opioids -- Receptors. --- Opioids. --- Receptors. --- Endorphins --- Opioids --- Receptors, Neuropeptide --- Biological Science Disciplines --- Opioid Peptides --- Receptors, G-Protein-Coupled --- Peptides --- Neuropeptides --- Receptors, Neurotransmitter --- Receptors, Cell Surface --- Receptors, Peptide --- Natural Science Disciplines --- Amino Acids, Peptides, and Proteins --- Nerve Tissue Proteins --- Disciplines and Occupations --- Membrane Proteins --- Chemicals and Drugs --- Proteins --- Receptors, Opioid --- Physiology --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Animal Biochemistry --- Neurology --- Receptors --- Opioid receptors --- Endorphin receptors --- Morphine receptors --- Narcotic receptors --- Opiate receptors --- Medicine. --- Neurosciences. --- Biomedicine. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system

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The evolution in our understanding of Opioid receptors and their subtypes is intimately linked to the development of new pharmacological treatments for diseases and disorders as diverse as addiction, self-injurious behavior, pain, cancer, inflammation, eating disorders, traumatic injury, pruritis and movement disorders. The contributions contained in Opioid Receptors and Antagonists: From Bench to Clinic represent efforts from leading international scientists and clinicians making use of the latest information emerging from the study of the opioid-receptor system. The authors use a variety of experimental and clinical approaches involving the fields of molecular biology, biochemistry, anatomy, pharmacology, behavioral neuroscience and psychiatry to illustrate rapidly developing experimental and therapeutic areas. Highlights include characterization of opioid receptors, chemistry and pharmacology of opiod antagonists for various receptor subtypes (Mu, Kappa, and Delta), discussion of therapeutic uses of opiod antagonists and exploration of innovative approaches to therapeutic drug delivery. Opioid Receptors and Antagonists: From Bench to Clinic offers a comprehensive view of recent work on opiod antagonist applications and uses in various clinical treatments. Emphasis is placed on disorders of the reward system. This volume serves as reference while also illuminating prospects for future research.

Endorphins. --- Endorphins --- Opioids --- Nervous system --- Peptides --- Central Nervous System Agents --- Mental Disorders --- Investigative Techniques --- Chemistry, Pharmaceutical --- Receptors, Neuropeptide --- Neuropeptides --- Therapeutics --- Receptors, G-Protein-Coupled --- Diseases --- Physiological Effects of Drugs --- Sensory System Agents --- Pharmacologic Actions --- Chemistry --- Therapeutic Uses --- Amino Acids, Peptides, and Proteins --- Receptors, Neurotransmitter --- Psychiatry and Psychology --- Receptors, Cell Surface --- Pharmacology --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Receptors, Peptide --- Peripheral Nervous System Agents --- Nerve Tissue Proteins --- Chemicals and Drugs --- Natural Science Disciplines --- Proteins --- Chemical Actions and Uses --- Membrane Proteins --- Biological Science Disciplines --- Disciplines and Occupations --- Narcotic Antagonists --- Receptors, Opioid --- Substance-Related Disorders --- Drug Discovery --- Drug Therapy --- Opioid Peptides --- Drug Delivery Systems --- Health & Biological Sciences --- Human Anatomy & Physiology --- Pharmacy, Therapeutics, & Pharmacology --- Animal Biochemistry --- Receptors --- Antagonists --- Chemotherapy --- Antagonists. --- Receptors. --- Chemotherapy. --- Opioid receptors --- Endorphin receptors --- Morphine receptors --- Narcotic receptors --- Opiate receptors --- Medicine. --- Pharmacology. --- Biomedicine. --- Pharmacology/Toxicology. --- Organs (Anatomy) --- Neurosciences --- Opioid peptides

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The need to continually discover new agents for the control or treatment of invertebrate pests and pathogens is undeniable. Agriculture, both animal and plant, succeeds only to the extent that arthropod and helminth consumers, vectors and pathogens can be kept at bay. Humans and their companion animals are also plagued by invertebrate parasites. The deployment of chemical agents for these purposes inevitably elicits the selection of resistant populations of the targets of control, necessitating a regular introduction of new kinds of molecules. Experience in other areas of chemotherapy has shown that a thorough understanding of the biology of disease is an essential platform upon which to build a discovery program. Unfortunately, investment of research resources into understanding the basic physiology of invertebrates as a strategy to illuminate new molecular targets for pesticide and parasiticide discovery has been scarce, and the pace of introduction of new molecules for these indications has been slowed as a result. An exciting and so far unexploited area to explore in this regard is invertebrate neuropeptide physiology. This book was assembled to focus attention on this promising field by compiling a comprehensive review of recent research on neuropeptides in arthropods and helminths, with contributions from many of the leading laboratories working on these systems.

Insect hormones. --- Neuropeptides. --- Pesticides. --- Neuropeptides --- Insect hormones --- Pesticides --- Invertebrates --- Peptides --- Receptors, Neurotransmitter --- Biological Science Disciplines --- Anti-Infective Agents --- Receptors, Peptide --- Nerve Tissue Proteins --- Receptors, Cell Surface --- Proteins --- Amino Acids, Peptides, and Proteins --- Natural Science Disciplines --- Animals --- Therapeutic Uses --- Eukaryota --- Membrane Proteins --- Chemicals and Drugs --- Disciplines and Occupations --- Pharmacologic Actions --- Chemical Actions and Uses --- Organisms --- Arthropods --- Antiparasitic Agents --- Helminths --- Pharmacology --- Receptors, Neuropeptide --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Economic poisons --- Brain peptides --- Medicine. --- Human physiology. --- Parasitology. --- Biomedicine. --- Human Physiology. --- Biomedicine general. --- Biology --- Human biology --- Medical sciences --- Physiology --- Human body --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Agricultural chemicals --- Pests --- Poisons --- Hormones --- Insects --- Nerve tissue proteins --- Neurotransmitters --- Control --- Equipment and supplies --- Endocrinology --- Medical parasitology. --- Human beings --- Human parasitology --- Parasitology --- Parasitic diseases --- Parasites --- Biomedicine, general. --- Health Workforce