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Histamine --- Receptors. --- Histamine receptors --- Receptors, Histamine --- Cell receptors --- Chemoreceptors

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In the early eighties when the H3 receptor was identified, many thought that an H3 ligand, an agonist or an antagonist, would become available as a therapeutic agent. This has not occurred. The reason for this could be the fact that many investigators consider histamine mainly, if not only, as a mediator present in for example mast cells being released during allergic events. However, it has become apparent that histamine is an important neurotransmitter. Its role in the nervous system, especially in the central part of it, is rather extensive. The H3 recepto

Histamine --- Neurotransmitter receptors. --- Cell receptors --- Hormone receptors --- Neural receptors --- Receptors, Neurotransmitter --- Chemoreceptors --- Histamine receptors --- Receptors, Histamine --- Receptors.

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Brain aminergic pathways are organized in parallel and interacting systems, which support a range of functions, from homoeostatic regulations to cognitive, and motivational processes. Despite overlapping functional influences, dopamine, serotonin, noradrenaline and histamine systems provide different contributions to these processes. The histaminergic system, long ignored as a major regulator of the sleep-wake cycle, has now been fully acknowledged also as a major coordinator of attention, learning and memory, decision making. Although histaminergic neurons project widely to the whole brain, they are functionally heterogeneous, a feature which may provide the substrate for differential regulation, in a region-specific manner, of other neurotransmitter systems. Neurochemical preclinical studies have clearly shown that histamine interacts and modulates the release of neurotransmitters that are recognized as major modulators of cognitive processing and motivated behaviours. As a consequence, the histamine system has been proposed as a therapeutic target to treat sleep-wake disorders and cognitive dysfunctions that accompany neurodegenerative and neuroinflammatory pathologies. Last decades have witnessed an unexpected explosion of interest in brain histamine system, as new receptors have been discovered and selective ligands synthesised. Nevertheless, the complete picture of the histamine systems fine-tuning and its orchestration with other pathways remains rather elusive.This Research Topic is intended to offer an inter-disciplinary forum that will improve our current understanding of the role of brain histamine and provide the fundamentals necessary to drive innovation in clinical practice and to improve the management and treatment of neurological disorders.We encourage a range of contributions, from preclinical to clinical experimental approaches, theoretical perspectives, and research highlights. Of paramount importance will be the contribution of medicinal chemists that have provided the animal research field with selective histaminergic compounds and explained their receptor and intracellular mechanisms of action.

Histamine --- Brain. --- Receptors. --- Cerebrum --- Mind --- Central nervous system --- Head --- Histamine receptors --- Receptors, Histamine --- Cell receptors --- Chemoreceptors --- anxiety --- cognition --- histamine receptors --- wakefulness --- heterogeneity

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Antihistamines --- Antihistaminica --- Antihistaminics --- Antihistaminiques --- Histamine --- Histamine antagonists --- Histamines--Antagonists --- Histamine. --- Histamine Antagonists. --- -Biogenic amines --- Ethylamines --- Imidazoles --- Inflammation --- Antiallergic agents --- Antagonists, Histamine --- Receptors, Histamine --- Receptors, Histamine H3 --- Ceplene --- Histamine Dihydrochloride --- Histamine Hydrochloride --- Peremin --- Dihydrochloride, Histamine --- Hydrochloride, Histamine --- Pathophysiology --- Mediators --- Antagonists --- antagonists & inhibitors --- Antihistamines. --- Pathophysiology. --- -Pathophysiology --- Histamine antagonists. --- Histamine Antagonists --- Biogenic amines --- Physiology [Pathological ] --- Antihistamine --- Histamine Antagonist --- Antagonist, Histamine

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Advances in Drug Research, Volume 21 comprises three chapters that deal with the general subject, specific therapeutic class, and chemical family of diverse drugs. The first chapter of this book discusses the absorption and distribution of drugs in the lymphatic system. A presentation of the anti-infective quinolones is provided in Chapter 2, while the design and therapeutic potential of peptides are elaborated in Chapter 3. Other topics covered include lymphotropic carriers and the lymph uptake mechanism; basis of circulation in lymphatic transport of molecules through various routes of admin

Drugs --- Histamine --- Medicinal plants. --- Drug plants --- Plants, Useful --- Botanical drug industry --- Botany, Medical --- Materia medica, Vegetable --- Psychotropic plants --- Histamine receptors --- Receptors, Histamine --- Cell receptors --- Chemoreceptors --- Pharmaceutical research --- Pharmacology --- Research. --- Receptors. --- Research