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Immunity, Cellular. --- Anti-antibodies --- Buffers --- Chemokines --- Clone cells --- Cytokines --- Enzyme-linked immunosorbent assay --- Flow cytometry --- Receptors, cytokine --- Anti-antibodies --- Buffers --- Chemokines --- Clone cells --- Cytokines --- Enzyme-linked immunosorbent assay --- Flow cytometry --- Receptors, cytokine

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Cytokines --- Receptors --- Cytokines. --- Receptors, Cytokine. --- Cytokine Receptor --- Receptors, Cytokines --- Cytokine Receptors --- Cytokines Receptors --- Receptor, Cytokine --- Cellular Immune Response --- Cell-Mediated Immunity --- Cell Mediated Immunity --- Cell-Mediated Immunities --- Cellular Immune Responses --- Cellular Immunities --- Cellular Immunity --- Immune Response, Cellular --- Immune Responses, Cellular --- Immunities, Cell-Mediated --- Immunities, Cellular --- Immunity, Cell-Mediated --- Response, Cellular Immune --- Interleukin-12 --- Immunity, Cellular --- Receptors, Cytokine --- Lymphokines --- T-Lymphocytes --- Cellular immunity --- Immune response --- Regulation --- Histology. Cytology --- General biochemistry --- General embryology. Developmental biology --- Cytokine --- Cytokines - Receptors

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Chemokine Receptors in Cancer summarizes the growing body of evidence that several chemokine receptors contribute to tumor behavior. Chemokine receptors were first identified on leukocytes and mediate directed migration of many host cells to sites of ligand expression. It is now well established that most malignant cells also express one or more chemokine receptor. This book describes our current understanding regarding how chemokine receptors contribute to tumor cell migration as well as cell survival and proliferation. The function of chemokine receptors expressed on host cells including antitumor immune effector cells as well as angiostatic and angiogeneic functions of chemokines acting on endothelial cells are described. The role of chemokine receptors that act as decoy receptors is also summarized. The therapeutic potential and challenges of targeting chemokine receptors or cognate ligands is also addressed.

Cancer cells --- Chemokines --- Receptors, Cytokine --- Antigens, CD --- Receptors, G-Protein-Coupled --- Diseases --- Angiogenesis Modulating Agents --- Growth Substances --- Receptors, Immunologic --- Antigens, Differentiation --- Receptors, Cell Surface --- Membrane Proteins --- Biological Markers --- Antigens, Surface --- Physiological Effects of Drugs --- Pharmacologic Actions --- Proteins --- Antigens --- Biological Factors --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Chemical Actions and Uses --- Angiogenesis Inducing Agents --- Neoplasms --- Receptors, Chemokine --- Biology --- Health & Biological Sciences --- Medicine --- Pharmacy, Therapeutics, & Pharmacology --- Oncology --- Microbiology & Immunology --- Growth --- Regulation. --- Receptors --- Effect of drugs on. --- Effect of drugs on --- Regulation --- Chemokines. --- Drug receptors. --- Drugs --- Receptors, Drug --- Chemotactic cytokines --- Inflammatory peptides --- Intercrines --- Medicine. --- Cancer research. --- Oncology. --- Biomedicine. --- Cancer Research. --- Cell receptors --- Cytokines --- Inflammation --- Peptides --- Mediators --- Oncology  . --- Tumors --- Cancer research

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Cell death, or apoptosis, plays an important role in biological processes and disease and offers special opportunities to develop new therapies for cancer, autoimmune disease, stroke, heart attack, and Alzheimer's disease. In Death Receptors in Cancer Therapy, leading physician-scientists and basic researchers review in depth our latest understanding of the molecular events that regulate cell death, illuminating those molecules that provide targets for agonists or antagonists designed to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particlar interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands. Authoritative and up-to-date, Death Receptors in Cancer Therapy offers a timely compendium of cell death signaling pathways for those seeking either a basic understanding of apoptosis or the knowledge needed to develop new therapeutics that will activate or block death signaling in disease.

Neoplasms --- Cell Death --- Gene Therapy --- Receptors, Tumor Necrosis Factor --- Apoptosis --- Cell receptors --- Cancer --- Cellular signal transduction --- Apoptose --- Récepteurs cellulaires --- Transduction du signal cellulaire --- immunology --- therapy --- methods --- Molecular aspects --- Aspect moléculaire --- Kanker --- Kanker ; moleculaire aspecten --- Apoptosis. --- Cancer -- Molecular aspects. --- Cell receptors. --- Cellular signal transduction. --- Biological Therapy --- Genetic Engineering --- Diseases --- Investigative Techniques --- Cell Physiological Processes --- Receptors, Cytokine --- Cell Physiological Phenomena --- Receptors, Immunologic --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Genetic Techniques --- Therapeutics --- Receptors, Cell Surface --- Phenomena and Processes --- Membrane Proteins --- Proteins --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Methods --- Medicine --- Biology --- Health & Biological Sciences --- Cytology --- Oncology --- Molecular aspects. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Medicine. --- Oncology. --- Medicine & Public Health. --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Binding sites (Biochemistry) --- Cell membranes --- Cell death

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Recently, the CXCR4/CXCL12-axis has been recognized as one of the pivotal adhesion pathways by which hematopoietic stem cells are retained in the bone marrow. CXCR4 antagonists with different chemical specification are being developed. Pharmacology research guides the way to the rational development of effective antagonists. One antagonist, plerixafor, is now clinically approved for stem cell mobilization of lymphoma and myeloma patients. This progress allows patients to receive potentially life-saving treatment which could not have been administered otherwise. Through early clinical studies it was recognized that CXCR4 antagonists also mobilize malignant hematopoietic cells, i.e. leukemia cells. In preclinical studies, a sensitization of mobilized leukemic cells to standard cytotoxic chemotherapy could be shown. CXCR4 antagonists are an exciting new class of compounds which are also used for the mobilization of angiogenic cells or for the treatment of solid tumors. This book provides concise reviews of novel developments, as well as possible future developments on CXCR4.  .

Hematopoietic stem cells -- Transplantation. --- Stem cells --Transplantation. --- Stem cells --- Hematopoietic stem cells --- Cancer --- Receptors, CXCR --- Stem Cell Transplantation --- Receptors, HIV --- Biological Therapy --- Bone Marrow Cells --- Metabolic Phenomena --- Chemicals and Drugs --- Stem Cells --- Cells --- Hematopoietic System --- Receptors, Chemokine --- Cell Transplantation --- Phenomena and Processes --- Receptors, Virus --- Therapeutics --- Antigens, CD --- Receptors, Cytokine --- Anatomy --- Hemic and Immune Systems --- Receptors, G-Protein-Coupled --- Transplantation --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Receptors, Cell Surface --- Receptors, Immunologic --- Antigens, Differentiation --- Membrane Proteins --- Surgical Procedures, Operative --- Proteins --- Antigens, Surface --- Biological Markers --- Amino Acids, Peptides, and Proteins --- Antigens --- Biological Factors --- Hematopoietic Stem Cells --- Receptors, CXCR4 --- Hematopoietic Stem Cell Mobilization --- Heterocyclic Compounds --- Hematopoietic Stem Cell Transplantation --- Metabolism --- Medicine --- Biology --- Health & Biological Sciences --- Oncology --- Cytology --- Therapeutic use --- Treatment --- Motility. --- Treatment. --- Cancer therapy --- Cancer treatment --- Cell motility --- Cell movement --- Cellular movement --- Motility of cells --- Therapy --- Movement --- Medicine. --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Biomechanics --- Cell physiology --- Oncology. --- Toxicology. --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Tumors --- Toxicology --- Cancer research --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect