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Central Nervous System --- Central Nervous System --- Chemokines --- Receptors, Chemokine --- cytology --- metabolism --- metabolism --- physiology

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Chemokine Receptors in Cancer summarizes the growing body of evidence that several chemokine receptors contribute to tumor behavior. Chemokine receptors were first identified on leukocytes and mediate directed migration of many host cells to sites of ligand expression. It is now well established that most malignant cells also express one or more chemokine receptor. This book describes our current understanding regarding how chemokine receptors contribute to tumor cell migration as well as cell survival and proliferation. The function of chemokine receptors expressed on host cells including antitumor immune effector cells as well as angiostatic and angiogeneic functions of chemokines acting on endothelial cells are described. The role of chemokine receptors that act as decoy receptors is also summarized. The therapeutic potential and challenges of targeting chemokine receptors or cognate ligands is also addressed.

Cancer cells --- Chemokines --- Receptors, Cytokine --- Antigens, CD --- Receptors, G-Protein-Coupled --- Diseases --- Angiogenesis Modulating Agents --- Growth Substances --- Receptors, Immunologic --- Antigens, Differentiation --- Receptors, Cell Surface --- Membrane Proteins --- Biological Markers --- Antigens, Surface --- Physiological Effects of Drugs --- Pharmacologic Actions --- Proteins --- Antigens --- Biological Factors --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Chemical Actions and Uses --- Angiogenesis Inducing Agents --- Neoplasms --- Receptors, Chemokine --- Biology --- Health & Biological Sciences --- Medicine --- Pharmacy, Therapeutics, & Pharmacology --- Oncology --- Microbiology & Immunology --- Growth --- Regulation. --- Receptors --- Effect of drugs on. --- Effect of drugs on --- Regulation --- Chemokines. --- Drug receptors. --- Drugs --- Receptors, Drug --- Chemotactic cytokines --- Inflammatory peptides --- Intercrines --- Medicine. --- Cancer research. --- Oncology. --- Biomedicine. --- Cancer Research. --- Cell receptors --- Cytokines --- Inflammation --- Peptides --- Mediators --- Oncology  . --- Tumors --- Cancer research

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Recently, the CXCR4/CXCL12-axis has been recognized as one of the pivotal adhesion pathways by which hematopoietic stem cells are retained in the bone marrow. CXCR4 antagonists with different chemical specification are being developed. Pharmacology research guides the way to the rational development of effective antagonists. One antagonist, plerixafor, is now clinically approved for stem cell mobilization of lymphoma and myeloma patients. This progress allows patients to receive potentially life-saving treatment which could not have been administered otherwise. Through early clinical studies it was recognized that CXCR4 antagonists also mobilize malignant hematopoietic cells, i.e. leukemia cells. In preclinical studies, a sensitization of mobilized leukemic cells to standard cytotoxic chemotherapy could be shown. CXCR4 antagonists are an exciting new class of compounds which are also used for the mobilization of angiogenic cells or for the treatment of solid tumors. This book provides concise reviews of novel developments, as well as possible future developments on CXCR4.  .

Hematopoietic stem cells -- Transplantation. --- Stem cells --Transplantation. --- Stem cells --- Hematopoietic stem cells --- Cancer --- Receptors, CXCR --- Stem Cell Transplantation --- Receptors, HIV --- Biological Therapy --- Bone Marrow Cells --- Metabolic Phenomena --- Chemicals and Drugs --- Stem Cells --- Cells --- Hematopoietic System --- Receptors, Chemokine --- Cell Transplantation --- Phenomena and Processes --- Receptors, Virus --- Therapeutics --- Antigens, CD --- Receptors, Cytokine --- Anatomy --- Hemic and Immune Systems --- Receptors, G-Protein-Coupled --- Transplantation --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Receptors, Cell Surface --- Receptors, Immunologic --- Antigens, Differentiation --- Membrane Proteins --- Surgical Procedures, Operative --- Proteins --- Antigens, Surface --- Biological Markers --- Amino Acids, Peptides, and Proteins --- Antigens --- Biological Factors --- Hematopoietic Stem Cells --- Receptors, CXCR4 --- Hematopoietic Stem Cell Mobilization --- Heterocyclic Compounds --- Hematopoietic Stem Cell Transplantation --- Metabolism --- Medicine --- Biology --- Health & Biological Sciences --- Oncology --- Cytology --- Therapeutic use --- Treatment --- Motility. --- Treatment. --- Cancer therapy --- Cancer treatment --- Cell motility --- Cell movement --- Cellular movement --- Motility of cells --- Therapy --- Movement --- Medicine. --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Biomechanics --- Cell physiology --- Oncology. --- Toxicology. --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Tumors --- Toxicology --- Cancer research --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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Chemokines and their receptors are being recognized as an integral component of the nervous system implicated in fundamental aspects of development and homeostasis, such as neurotransmission, proliferation, differentiation, and neuronal-glial communication. Thus, their involvement in HIV neuropathology goes far beyond the co-receptors role and entails complex interactions of the chemokine system with different cell types and other regulators of neuronal function. The major goal of this volume is to review these topics in order to highlight alterations of chemokine physiology that may contribute to neuroAIDS and other neuropathologies. This book will be of interest to neuroscientists, neurologists, virologists, pharmacologists, and students in these fields. About the Editor: Olimpia Meucci, MD, PhD is a Professor of Pharmacology and Physiology & Microbiology and Immunology at Drexel University College of Medicine in Philadelphia, PA. Since her seminal discovery about the regulation of neuronal signaling by chemokines, her research has primarily focused on the physio-pathological roles of this important class of neuroimmune modulators in the central nervous system and their involvement in neuroAIDS. These studies have significantly contributed to current understanding of the cellular and molecular mechanisms of HIV-related neuropathology including the interaction of the chemokine system with drug of abuse, namely opiates, which continues to be a major area of investigation in the Meucci lab.

AIDS (Disease) -- Complications -- Treatment. --- Chemokines -- Receptors. --- Chemokines. --- HIV infections -- Complications -- Treatment. --- Chemokines --- AIDS (Disease) --- HIV infections --- Nervous system --- Antigens, CD --- Cytokines --- Diseases --- Immunologic Deficiency Syndromes --- Inflammation Mediators --- Receptors, Cytokine --- Sexually Transmitted Diseases, Viral --- Biological Science Disciplines --- Slow Virus Diseases --- Receptors, G-Protein-Coupled --- Lentivirus Infections --- Chemotactic Factors --- Physiology --- Acquired Immunodeficiency Syndrome --- Nervous System Diseases --- HIV Infections --- Receptors, Chemokine --- Immune System Diseases --- Intercellular Signaling Peptides and Proteins --- Antigens, Differentiation --- Sexually Transmitted Diseases --- Biological Factors --- Natural Science Disciplines --- Retroviridae Infections --- Receptors, Cell Surface --- Receptors, Immunologic --- Virus Diseases --- Proteins --- Chemicals and Drugs --- Disciplines and Occupations --- Antigens, Surface --- RNA Virus Infections --- Peptides --- Membrane Proteins --- Biological Markers --- Amino Acids, Peptides, and Proteins --- Antigens --- Medicine --- Biology --- Microbiology & Immunology --- Neurology --- Health & Biological Sciences --- Receptors --- Complications --- Treatment --- Chemotherapy --- Receptors. --- Treatment. --- Chemotherapy. --- HIV (Viruses) infections --- HTLV-III infections --- HTLV-III-LAV infections --- Human T-lymphotropic virus III infections --- Acquired immune deficiency syndrome --- Acquired immunodeficiency syndrome --- Acquired immunological deficiency syndrome --- Chemotactic cytokines --- Inflammatory peptides --- Intercrines --- Medicine. --- Neurosciences. --- Pharmacology. --- Virology. --- Infectious diseases. --- Biomedicine. --- Pharmacology/Toxicology. --- Infectious Diseases. --- Organs (Anatomy) --- Neurosciences --- Lentivirus infections --- Sexually transmitted diseases --- Immunological deficiency syndromes --- Virus-induced immunosuppression --- Inflammation --- Mediators --- Medical virology. --- Toxicology. --- Emerging infectious diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Medical microbiology --- Virology --- Virus diseases --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Toxicology --- Drug effects --- Medical pharmacology --- Drugs --- Pharmacy --- Microbiology --- Physiological effect