Abstract | Keywords | Export | Availability | Bookmark

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Recently, the CXCR4/CXCL12-axis has been recognized as one of the pivotal adhesion pathways by which hematopoietic stem cells are retained in the bone marrow. CXCR4 antagonists with different chemical specification are being developed. Pharmacology research guides the way to the rational development of effective antagonists. One antagonist, plerixafor, is now clinically approved for stem cell mobilization of lymphoma and myeloma patients. This progress allows patients to receive potentially life-saving treatment which could not have been administered otherwise. Through early clinical studies it was recognized that CXCR4 antagonists also mobilize malignant hematopoietic cells, i.e. leukemia cells. In preclinical studies, a sensitization of mobilized leukemic cells to standard cytotoxic chemotherapy could be shown. CXCR4 antagonists are an exciting new class of compounds which are also used for the mobilization of angiogenic cells or for the treatment of solid tumors. This book provides concise reviews of novel developments, as well as possible future developments on CXCR4.  .

Hematopoietic stem cells -- Transplantation. --- Stem cells --Transplantation. --- Stem cells --- Hematopoietic stem cells --- Cancer --- Receptors, CXCR --- Stem Cell Transplantation --- Receptors, HIV --- Biological Therapy --- Bone Marrow Cells --- Metabolic Phenomena --- Chemicals and Drugs --- Stem Cells --- Cells --- Hematopoietic System --- Receptors, Chemokine --- Cell Transplantation --- Phenomena and Processes --- Receptors, Virus --- Therapeutics --- Antigens, CD --- Receptors, Cytokine --- Anatomy --- Hemic and Immune Systems --- Receptors, G-Protein-Coupled --- Transplantation --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Receptors, Cell Surface --- Receptors, Immunologic --- Antigens, Differentiation --- Membrane Proteins --- Surgical Procedures, Operative --- Proteins --- Antigens, Surface --- Biological Markers --- Amino Acids, Peptides, and Proteins --- Antigens --- Biological Factors --- Hematopoietic Stem Cells --- Receptors, CXCR4 --- Hematopoietic Stem Cell Mobilization --- Heterocyclic Compounds --- Hematopoietic Stem Cell Transplantation --- Metabolism --- Medicine --- Biology --- Health & Biological Sciences --- Oncology --- Cytology --- Therapeutic use --- Treatment --- Motility. --- Treatment. --- Cancer therapy --- Cancer treatment --- Cell motility --- Cell movement --- Cellular movement --- Motility of cells --- Therapy --- Movement --- Medicine. --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Biomechanics --- Cell physiology --- Oncology. --- Toxicology. --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Tumors --- Toxicology --- Cancer research --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect