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Biology of the NMDA receptor
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ISBN: 1420044141 9786611863135 1281863130 142004415X 0429144849 Year: 2008 Publisher: Boca Raton : CRC Press,

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Abstract

The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written by one of the world's leading authorities on NMDA receptors, ""Biology of the NMDA Receptor"" brings together virtually all the players in this important field.


Book
GABA and sleep : molecular, functional and clinical aspects
Authors: --- ---
ISBN: 3034807406 3034602251 9786612979668 303460226X 1282979663 Year: 2010 Publisher: Basel : Springer,

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GABA (gamma-aminobutyric acid) is the main neurotransmitter regulating sleep. The majority of drugs presently in use for the treatment of sleep disorders act by enhancing GABAergic neuronal inhibition. This book brings together many of the world’s leading investigators to discuss current and anticipated developments in the areas of geriatric sleep medicine and provides a comprehensive examination of current principles and practice in this field. It is divided into three main sections: Section I: Basic Physiology and Pharmacology Section II: Sleep Science and Circuitry Section III: Neurotherapeutics The areas covered include findings from research investigations various aspects of GABAergic systems and the regulation of sleep. The book is suitable for basic and clinical neuropharmacologists, sleep researchers, psychiatrists, sleep disorders specialists, clinicians, medical students, and all professionals interested in the interdisciplinary areas of sleep and neuropharmacology.

Dopamine and glutamate in psychiatric disorders
Authors: ---
ISBN: 9781592598526 1588293254 9781588293251 1617374954 9786610359639 1280359633 1592598528 Year: 2005 Publisher: Totowa, N.J. : Humana Press,

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Continuous rigorous research in basic neurosciences and in clinical studies has enormously increased our knowledge of the neurobiological basis of mental functions and of the neuronal dysfunctions underlying such diseases as schizophrenia, depression, attention deficit disorder, and Parkinson's disease. A transmitter system does not work in isolation, it interacts with other transmitters and the balance between several transmitter determines the outcome, either physiological or pathological. Such a critical balance exists between dopamine and glutamate, which in many brain areas play functionally opposing roles. In Dopamine and Glutamate in Psychiatric Disorders, a panel of neurochemists, pharmacologists, experimental psychologists, and clinicians summarizes our current understanding of the interactive role of dopamine and glutamate in psychiatric diseases and from that develops novel therapeutic strategies and possibilities for the future. Among the new ideas presented are hypotheses on the role of dopamine and glutamate in aggression, the glutamate system in anxiety disorders, glutamate and neurodegeneration, on the origin, progression, and cognitive aspects of Parkinson's disease. Additional chapters offer illuminating insights into a variety of psychiatric diseases, including attention deficit hyperactivity disorder, stress, aggression, addiction, schizophrenia, depression, social phobias, dementias, bulimia, and neurodegenerative diseases like Parkinson's and Alzheimer's diseases. Each chapter summarizes the prevalence and symptoms of the disease and explains the involvement of dopamine and/or glutamate systems using the newer molecular approaches such as transgenic knockout or knockin mice and recent brain imaging techniques. The authors also offer a critical selection and evaluation of relevant literature and a description of future directions for new therapy development. Path-breaking and insightful, Dopamine and Glutamate in Psychiatric Disorders offers behavioral pharmacologists, neurobiologists, and clinicians an enlightening review of the neurobiological basis and treatment strategies of today's most important psychiatric and neurological diseases.

Keywords

Medicine & Public Health. --- Psychiatry. --- Medicine. --- Médecine --- Psychiatrie --- Antidepressive Agents -- pharmacology. --- Antipsychotic Agents -- pharmacology. --- Dopamine -- Pathophysiology. --- Glutamate -- Pathophysiology. --- Mental Disorders -- drug therapy. --- Mental Disorders -- etiology. --- Nervous System Diseases -- drug therapy. --- Nervous System Diseases -- etiology. --- Neuropsychiatry. --- Neurotransmitter receptors. --- Neuropsychiatry --- Dopamine --- Glutamate --- Neurotransmitter receptors --- Tranquilizing Agents --- Receptors, Catecholamine --- Amino Acids, Dicarboxylic --- Psychiatry and Psychology --- Psychotropic Drugs --- Excitatory Amino Acids --- Receptors, Amino Acid --- Diseases --- Amino Acids, Acidic --- Catecholamines --- Central Nervous System Agents --- Amino Acids --- Receptors, Biogenic Amine --- Central Nervous System Depressants --- Biogenic Monoamines --- Receptors, Neurotransmitter --- Receptors, G-Protein-Coupled --- Amines --- Amino Acids, Peptides, and Proteins --- Receptors, Cell Surface --- Biogenic Amines --- Organic Chemicals --- Physiological Effects of Drugs --- Therapeutic Uses --- Pharmacologic Actions --- Membrane Proteins --- Chemicals and Drugs --- Proteins --- Chemical Actions and Uses --- Antidepressive Agents --- Antipsychotic Agents --- Mental Disorders --- Glutamic Acid --- Receptors, Dopamine --- Receptors, Glutamate --- Nervous System Diseases --- Medicine --- Psychiatry --- Health & Biological Sciences --- Neurology --- Psychiatry - General --- Pathophysiology --- Glutamic acid --- Pathophysiology. --- Behavioral neurology --- Medicine and psychology --- Mental health --- Psychology, Pathological --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Excitatory amino acids --- Umami (Taste) --- Biogenic amines --- Bromocriptine --- Neurotransmitters --- Biological psychiatry --- Cell receptors --- Hormone receptors --- Neural receptors


Book
Kainate receptors : novel signaling insights
Authors: ---
ISBN: 1441995560 1441995579 Year: 2011 Publisher: New York : Austin, Tex. : Springer Science+Business Media ; Landes Bioscience,

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"This volume critically examines the functional actions of the kainate type glutamate receptors (KARs). Following on from the larger body of work on the NMDA and AMPA-type ionotropic glutamate receptors (GluRs), studies with KARs have consistently thrown up exceptions to general rules about synaptic modulation. Contributors herein provide an insight to the idiosyncracies that now almost typify the KAR field. The fascinating insights provided in this volume serve to encourage searching mechanistic questions"--Provided by publisher.

Keywords

Cellular signal transduction. --- Cerebrum -- physiology. --- Kainic acid -- Physiological effect. --- Kainic acid -- Receptors. --- Receptors, Kainic Acid -- physiology. --- Signal Transduction -- physiology. --- Kainic acid --- Cellular signal transduction --- Receptors, Ionotropic Glutamate --- Cell Physiological Processes --- Biological Science Disciplines --- Biochemical Processes --- Telencephalon --- Ligand-Gated Ion Channels --- Prosencephalon --- Cell Physiological Phenomena --- Natural Science Disciplines --- Chemical Processes --- Biochemical Phenomena --- Receptors, Glutamate --- Chemical Phenomena --- Ion Channels --- Receptors, Amino Acid --- Phenomena and Processes --- Brain --- Disciplines and Occupations --- Membrane Glycoproteins --- Membrane Transport Proteins --- Receptors, Neurotransmitter --- Central Nervous System --- Membrane Proteins --- Carrier Proteins --- Nervous System --- Receptors, Cell Surface --- Proteins --- Anatomy --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Cerebrum --- Receptors, Kainic Acid --- Signal Transduction --- Physiology --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Physiological effect --- Receptors --- Physiological effect. --- Receptors. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Digenic acid --- Medicine. --- Molecular biology. --- Biomedicine. --- Biomedicine general. --- Molecular Medicine. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Amino acids --- Anthelmintics --- Neurotoxic agents --- Pyrrolidine --- Health Workforce --- Biomedicine, general.

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