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This book aims to present the age-related alterations in redox signaling networks and their diagnostic biomarkers in aging cells using multidisciplinary approach. Establishing sensitive and specific biomarkers of dynamic redox homeostasis is crucially important in the development of effective antiaging and senolytic interventions. Recent years have seen tremendous advances in the understanding of redox signaling events which highlight the process of aging and age-related pathologies. A major challenge in biological aging research is developing reliable biomarkers to determine the consequences of disrupted redox signaling networks long before the clinical diagnosis of age-related diseases is made. Therefore, we have chosen to concentrate on aging-induced aberrant redox signaling networks, their biomarkers, and pathological consequences in this book. Although oxidation is a natural metabolic process, the imbalance in the level of oxidants and antioxidants causes oxidative stress and eventually leads to inflammatory conditions, diabetes, neurodegenerative diseases, and cancer. Novel redox-sensitive biomarkers for the evaluation of aging-induced proteinopathies such as amyloid ß and tau proteins in Alzheimer's disease, α-synuclein in Parkinson's disease, and islet amyloid polypeptides in type 2 diabetes mellitus recently drew the attention of researchers. Inside this textbook, readers will find comprehensive perspectives on the association between redox homeostasis and the aging process both at the molecular and clinical levels. Due to the inherent relationship between impaired metabolic activities and oxidative stress, the temporal interaction between intermediary metabolism and disturbed redox status can lead to greater susceptibility to aging-induced diseases and disorders, such as cardiovascular diseases, hypertension, and diabetes. This knowledge could be a key to continued research toward improving medication regimens such as in cancer and cardiovascular therapies, and procedural outcomes for patients. This book brings together current research evidence and knowledge on redox signaling and biomarkers in aging in chapters written by leading global experts in this rapidly evolving field. We hope that this textbook is of interest to a wide group of researchers, advanced students, scientifically curious non-specialist readers and clinicians alike. .

General biochemistry --- Physiology: reproduction & development. Ages of life --- Geriatrics --- veroudering (biologie) --- biochemie --- geriatrie --- Biochemical markers. --- Oxidation-reduction reaction. --- Aging --- Molecular aspects. --- Vellesa --- Marcadors bioquímics --- Oxidació fisiològica --- Reacció d'oxidació-reducció --- Molecular aspects

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This book addresses several burning issues concerning diseases involving the lungs and respiratory tract. It discusses the epidemiology, mechanisms, prevention, and diagnosis of chest conditions such as chronic obstructive pulmonary disease, sleep apnea and respiratory infections. Further, it examines the intertwined connection between oxidative stress, cardiovascular disorders such as hypertension, and the occurrence and course of obstructive sleep apnea. It also provides pulmonologists with valuable information on the diagnosis and treatment of patients with severe airway obstruction or respiratory tract infections. Other topics covered include viral infections of the airways, such as influenza, particularly in high-risk groups like pediatric populations, as well as psychosocial aspects, e.g., quality of life in lung cancer patients. Combining basic science and clinical practice, the articles provide key insights and highlight the areas of still limited understanding of disease processes. Stimulating new directions in clinical practice, this collection of articles is intended for respiratory physicians, clinical experts, family practitioners, and all allied healthcare professionals.

Neurosciences. --- Respiratory organs—Diseases. --- Oxidative stress. --- Pneumology/Respiratory System. --- Oxidative Stress. --- Oxidation-reduction reaction --- Stress (Physiology) --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Estrès oxidatiu --- Malalties dels pulmons --- Neurociències --- Neurociència --- Ciències neurològiques --- Ciències de la salut --- Neuroanatomia --- Neurobiologia --- Neurociència computacional --- Neuroendocrinologia --- Neurofarmacologia --- Neurogenètica --- Neuroquímica --- Sistema nerviós --- Malalties pulmonars --- Pneumopaties --- Bronquitis --- Displàsia broncopulmonar --- Fibrosi pulmonar --- Fibrosi quística --- Insuficiència respiratòria --- Legionel·losi --- Malalties pulmonars obstructives cròniques --- Pneumònia --- Pneumotòrax --- Estrès (Fisiologia) --- Reacció d'oxidació-reducció --- Malalties del pulmó

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This book illustrates the importance and significance of oxidative stress in the pathophysiology of various human diseases. The book initially introduces the phenomenon of oxidative stress, basic chemical characteristics of the species involved and summarizes the cellular oxidant and anti-oxidant system and the cellular effects and metabolism of the oxidative stress. In addition, it reviews the current understanding of the potential impact of oxidative stress on telomere shortening, aging, and age-related diseases. It also examines the role of oxidative stress in chronic diseases, including cancer, diabetes, cardiovascular diseases, and neurodegenerative disorders. Further, the book presents novel technologies for the detection of oxidative stress biomarkers using nanostructure biosensors, as well as in vitro and in vivo models to monitor oxidative stress. Lastly, the book addresses the drug delivery carriers that can help in combating oxidative stress.

Oxidative stress. --- Physiology, Pathological. --- Clinical physiology --- Pathological physiology --- Pathophysiology --- Physiopathology --- Pathology --- Physiology --- Oxidation-reduction reaction --- Stress (Physiology) --- Human physiology. --- Cancer research. --- Diabetes. --- Neurosciences. --- Nanotechnology. --- Oxidative Stress. --- Human Physiology. --- Cancer Research. --- Molecular technology --- Nanoscale technology --- High technology --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Brittle diabetes --- Diabetes mellitus --- IDDM (Disease) --- Insulin-dependent diabetes --- Ketosis prone diabetes --- Type 1 diabetes --- Carbohydrate intolerance --- Endocrine glands --- Diabetic acidosis --- Glycosylated hemoglobin --- Cancer research --- Human biology --- Human body --- Diseases --- Fisiologia patològica --- Estrès oxidatiu --- Estrès (Fisiologia) --- Reacció d'oxidació-reducció --- Fisiopatologia --- Patofisiologia --- Patologia molecular

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Expanding upon the research elucidated by the first volume of this collection, Advanced Protocols in Oxidative Stress II presents thirty additional cutting-edge chapters focusing on novel techniques for detecting ROS/RNS, unique AOX technology and applications, gene expression and biostatistics for evaluating OS-derived experimental data. The international panel of authors also provide animal models and numerous studies concentrating on mitochondria during hypoxic conditions using advanced methods for pO2, peroxynitrate, reactive S-nitrosothiols, lipid peroxides, COX, and the mitochondrial membrane potential. Due to the dynamic nature of this topic, this book is the second of several volumes of Advanced Protocols in Oxidative Stress, all included in the highly successful Methods in Molecular Biology™ series. As part of the series, the chapters of this volume present brief introductions to the respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting to ensure easy replication of the technology involved. Authoritative and convenient, Advanced Protocols in Oxidative Stress II is an ideal desk reference for scientists wishing to further the research in this exciting, unique, and vital field of study.

Biochemistry. --- Cytology. --- Analytical biochemistry. --- Biochemistry, general. --- Cell Biology. --- Analytical Chemistry. --- Oxidative Stress. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Analytic biochemistry --- Biochemistry --- Chemistry, Analytic --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Composition --- Bioanalytic chemistry --- Bioanalytical chemistry --- Analytical chemistry --- Estrès oxidatiu --- Bioquímica --- Manuals de laboratori --- Química biològica --- Química fisiològica --- Biologia --- Medicina --- Química --- Absorció (Fisiologia) --- Anàlisi enzimàtica --- Biodegradació --- Biodisponibilitat --- Bioelectroquímica --- Bioenergètica --- Biogeoquímica --- Biologia molecular --- Bioquímica analítica --- Bioquímica clínica --- Bioquímica física --- Bioquímica quàntica --- Biosíntesi --- Centres actius (Bioquímica) --- Citoquímica --- Composició del cos humà --- Cromatografia --- Digestió --- Enginyeria bioquímica --- Enzimologia --- Equilibri àcid-base --- Fitoquímica --- Fixació de proteïnes --- Genètica bioquímica --- Immunoquímica --- Interfícies biològiques --- Lípids --- Lligands (Bioquímica) --- Marcadors bioquímics --- Metabolisme --- Minerals en l'organisme --- Neuroquímica --- Oxidació fisiològica --- Pigments (Biologia) --- Química biorgànica --- Química clínica --- Química microbiològica --- Quimiotaxi --- Quimiotaxonomia --- Toxicologia bioquímica --- Xenobiòtics --- Histoquímica --- Estrès (Fisiologia) --- Reacció d'oxidació-reducció --- Tècniques de laboratori

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Cinètica química --- Bioquímica --- Reaccions químiques --- Química --- Ciclització (Química) --- Condensació aldòlica --- Condensació de Darzens --- Explosions --- Fosforilació --- Hidroformilació --- Hidrogenació --- Isomerització --- Metàtesi (Química) --- Nitració --- Oxidació --- Ozonització --- Piròlisi --- Polimerització --- Reacció aldòlica --- Reacció d'oxidació-reducció --- Reacció de Diels-Alder --- Reacció de Maillard --- Reaccions d'addició --- Reaccions d'eliminació --- Reaccions d'intercanvi --- Reaccions de radicals lliures --- Reaccions de substitució --- Reaccions unimoleculars --- Reactors químics --- Reducció química --- Sulfonació --- Intermediaris (Química) --- Processos químics --- Química biològica --- Química fisiològica --- Biologia --- Medicina --- Absorció (Fisiologia) --- Anàlisi enzimàtica --- Biodegradació --- Biodisponibilitat --- Bioelectroquímica --- Bioenergètica --- Biogeoquímica --- Biologia molecular --- Bioquímica analítica --- Bioquímica clínica --- Bioquímica física --- Bioquímica quàntica --- Biosíntesi --- Centres actius (Bioquímica) --- Citoquímica --- Composició del cos humà --- Cromatografia --- Digestió --- Enginyeria bioquímica --- Enzimologia --- Equilibri àcid-base --- Fitoquímica --- Fixació de proteïnes --- Genètica bioquímica --- Immunoquímica --- Interfícies biològiques --- Lípids --- Lligands (Bioquímica) --- Marcadors bioquímics --- Metabolisme --- Minerals en l'organisme --- Neuroquímica --- Oxidació fisiològica --- Pigments (Biologia) --- Química biorgànica --- Química clínica --- Química microbiològica --- Quimiotaxi --- Quimiotaxonomia --- Toxicologia bioquímica --- Xenobiòtics --- Histoquímica --- Velocitat de reacció (Química) --- Afinitat química --- Reactivitat (Química) --- Cinètica enzimàtica --- Farmacocinètica --- Chemical kinetics. --- Chemical reaction, Kinetics of --- Chemical reaction, Rate of --- Chemical reaction, Velocity of --- Chemical reaction rate --- Chemical reaction velocity --- Kinetics, Chemical --- Rate of chemical reaction --- Reaction rate (Chemistry) --- Velocity of chemical reaction --- Chemical affinity --- Reactivity (Chemistry)