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Genetic disorders. --- Noonan Syndrome --- Noonan Syndrome --- Ras oncogenes. --- Ras proteins. --- Signal Transduction. --- Ras Proteins --- Genetics. --- Physiopathology. --- Genetics.

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Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10–30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies. This brief involves extensive role of the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs. SNP Studies and Structure based drug discovery will also be undertaken.

Engineering. --- Computational Intelligence. --- Computational Biology/Bioinformatics. --- Cancer Research. --- Biomedical Engineering. --- Health Informatics. --- Appl.Mathematics/Computational Methods of Engineering. --- Oncology. --- Medical records --- Bioinformatics. --- Engineering mathematics. --- Biomedical engineering. --- Ingénierie --- Cancérologie --- Dossiers médicaux --- Bio-informatique --- Mathématiques de l'ingénieur --- Génie biomédical --- Data processing. --- Informatique --- Medical records_xData processing. --- Engineering & Applied Sciences --- Computer Science --- Ras oncogenes. --- Lungs --- Cancer. --- Lung cancer --- Bio-informatics --- Biological informatics --- Ras genes --- Mathematical and Computational Engineering. --- Biology --- Information science --- Computational biology --- Systems biology --- Guanosine triphosphatase genes --- Oncogenes --- Data processing --- Biomedical Engineering and Bioengineering. --- Engineering --- Engineering analysis --- Mathematical analysis --- EHR systems --- EHR technology --- EHRs (Electronic health records) --- Electronic health records --- Electronic medical records --- EMR systems --- EMRs (Electronic medical records) --- Information storage and retrieval systems --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Medicine --- Tumors --- Construction --- Industrial arts --- Technology --- Mathematics --- Medical care --- Computational intelligence. --- Cancer research. --- Health informatics. --- Applied mathematics. --- Clinical informatics --- Health informatics --- Medical information science --- Cancer research --- Intelligence, Computational --- Artificial intelligence --- Soft computing