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Cancer --- Rapamycin. --- Molecular aspects. --- Sirolimus --- Immunosuppressive agents --- Macrolide antibiotics

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Translationally controlled tumor protein (TCTP), also referred to as HRF or fortilin, is a multifunctional protein, expressed in all eukaryotic organisms from protozoa to humans. TCTP is involved in many basic biological processes, such as cell division, growth, and development. It is therefore not surprising that dysregulation of TCTP occurs in various disease processes, such as cardiovascular, allergic, and immune disorders. TCTP’s role in cancer-promoting pathways is well- documented, and the protein is considered a potential target for the design of new anti-cancer strategies. Therefore, an understanding of the core biological functions of TCTP, the mechanisms underlying its cellular regulation, and its involvement in disease processes is important. This book provides a current overview on the basic biological functions of TCTP and on its role in promoting a range of disease processes.

Research & information: general --- Biology, life sciences --- Loxosceles --- brown spider --- TCTP --- venom --- toxin --- HRF --- allergy --- mast cells --- basophils --- IgE --- FcεRI --- translationally controlled tumor protein (TCTP) --- apoptosis --- conditional knockout mice --- development --- Nestin-cre --- neurogenesis --- neuronal progenitor cells --- perinatal death --- proliferation --- Mmi1 --- translationally controlled tumor protein --- autophagy --- reactive oxygen species --- rapamycin --- nitrogen starvation --- cancer --- phospho-TCTP --- DHA --- T-DM1 --- HER2-positive breast cancer --- TCTP (HRF --- fortilin) --- growth and development --- biological stress reactions --- regulation of protein synthesis --- regulated protein degradation --- cardiovascular diseases --- Loxosceles --- brown spider --- TCTP --- venom --- toxin --- HRF --- allergy --- mast cells --- basophils --- IgE --- FcεRI --- translationally controlled tumor protein (TCTP) --- apoptosis --- conditional knockout mice --- development --- Nestin-cre --- neurogenesis --- neuronal progenitor cells --- perinatal death --- proliferation --- Mmi1 --- translationally controlled tumor protein --- autophagy --- reactive oxygen species --- rapamycin --- nitrogen starvation --- cancer --- phospho-TCTP --- DHA --- T-DM1 --- HER2-positive breast cancer --- TCTP (HRF --- fortilin) --- growth and development --- biological stress reactions --- regulation of protein synthesis --- regulated protein degradation --- cardiovascular diseases

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Translationally controlled tumor protein (TCTP), also referred to as HRF or fortilin, is a multifunctional protein, expressed in all eukaryotic organisms from protozoa to humans. TCTP is involved in many basic biological processes, such as cell division, growth, and development. It is therefore not surprising that dysregulation of TCTP occurs in various disease processes, such as cardiovascular, allergic, and immune disorders. TCTP’s role in cancer-promoting pathways is well- documented, and the protein is considered a potential target for the design of new anti-cancer strategies. Therefore, an understanding of the core biological functions of TCTP, the mechanisms underlying its cellular regulation, and its involvement in disease processes is important. This book provides a current overview on the basic biological functions of TCTP and on its role in promoting a range of disease processes.

Loxosceles --- brown spider --- TCTP --- venom --- toxin --- HRF --- allergy --- mast cells --- basophils --- IgE --- FcεRI --- translationally controlled tumor protein (TCTP) --- apoptosis --- conditional knockout mice --- development --- Nestin-cre --- neurogenesis --- neuronal progenitor cells --- perinatal death --- proliferation --- Mmi1 --- translationally controlled tumor protein --- autophagy --- reactive oxygen species --- rapamycin --- nitrogen starvation --- cancer --- phospho-TCTP --- DHA --- T-DM1 --- HER2-positive breast cancer --- TCTP (HRF --- fortilin) --- growth and development --- biological stress reactions --- regulation of protein synthesis --- regulated protein degradation --- cardiovascular diseases --- n/a

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This book aims to provide novel insights into the mechanisms of embryo implantation and placental development, as well as at present an overview of the current knowledge on the different signaling pathways regulating the early steps of implantation and placentation, and on the pathological alterations which may impair the establishment of a physiological pregnancy.

Research & information: general --- Biology, life sciences --- fetuin-A --- GDM --- cell growth --- centrosome --- primary cilium --- autophagy --- implantation --- endometrium --- blastocyst --- embryo --- chorionic gonadotropin --- progesterone --- Notch --- cytokines --- placenta --- amino acid transporter --- mammalian target of rapamycin --- gestational diabetes --- trophectoderm --- cell proliferation --- let-7 miRNAs --- gene regulation --- fractalkine --- trophoblast --- bilaminar co-culture --- miRNA --- trophoblast cells --- ARID3B complex --- decidualization --- adverse pregnancy outcome --- preconception --- preimplantation genetic screening --- in-vitro fertilization --- biopsy --- euploid embryo --- pregnancy --- mosaicism --- development --- flow culture --- KIT receptor --- KITD816V --- placental development --- premature differentiation --- trophoblast stem cell --- trophoblast giant cell --- spongiotrophoblast --- invasion --- embryonic growth retardation --- Jag1 --- Dll4 --- endothelial cells --- decidua --- angiogenesis --- capillaries --- spiral arteries --- Stabilin-1 --- Stabilin-2 --- double knockout --- hemorrhage --- RNA-seq --- ChIP-seq --- enhancers --- transcription factors --- PLAGL1 --- tube formation --- blood vessel development --- PlGF --- Flt-1/VEGFR1 --- immune modulation --- human placenta --- lopinavir --- mitochondria --- Mfn2 --- UPR --- IRE1α --- placental dysfunction --- assisted reproduction techniques --- infertility --- preeclampsia --- intrauterine growth restriction --- trophoblast invasion --- sFLT-1 --- EGFL7 --- placenta-derived mesenchymal stromal cells --- mouse model

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Dilated cardiomyopathy (DCM) is a particular phenotype of non-ischemic systolic heart failure, frequently recognizing a genetic background and affecting relatively young patients with few comorbidities. Nowadays, long-term survival of DCM patients has been markedly improved due to an early diagnosis and uninterrupted and tailored follow-up under constant optimal medical and non-pharmacological evidence-based treatments. Nevertheless, DCM is still one of the most common causes of heart transplantation in the western world. Clinical management requires an integrated and systematic use of diagnostic tools and a deeper investigation of the basic mechanisms underlying the disease. However, several emerging issues remain debated. Specifically, the genotype–phenotype correlation, the role of advanced imaging techniques and genetic testing, the lack of appropriate risk stratification models, the need for a multiparametric and multidisciplinary approach for device implantation, and a continuous reclassification of the disease during follow-up remain challenging issues in clinical practice. Therefore, the aim of this Special Issue is to shed the light on the most recent advancements in characterization and clinical management of DCM in order to unveil the conundrum of this particular disease.

SCN5A --- cardiac sodium channel --- cardiac channelopathy --- dilated cardiomyopathy --- precision medicine --- arrhythmias --- atrial fibrillation --- cardiomyopathy --- heart failure --- supraventricular arrhythmia --- systolic dysfunction --- tachycardiomyopathy --- ventricular arrhythmia --- left atrial strain --- cardiac resynchronization therapy --- muscular dystrophy --- calcium --- heart --- gene therapy --- phospholamban --- Serca2a --- mdx --- oxidative stress --- membrane stabilization --- left ventricular noncompaction --- congenital heart disease --- congestive heart failure --- non-ischemic cardiomyopathy --- genetics --- desmin --- mitochondrial dysfunction --- myopathy --- whole exome sequencing --- laminopathy --- LMNA --- biomarkers --- troponin T --- NT-proBNP --- malignant ventricular arrhythmia --- arrhythmic risk stratification --- DNA methylation --- alternative splicing --- epigenetics --- nonischemic dilated cardiomyopathy --- cardiac magnetic resonance imaging --- late gadolinium enhancement --- long axis strain --- left ventricle sphericity index --- major adverse cardiovascular events --- sex differences --- left ventricular reverse remodelling --- long-term outcomes --- left ventricle non-compaction cardiomyopathy --- cardiac magnetic resonance --- titin --- RNA binding motif protein 20 (RBM20) --- sarcomere --- diastolic dysfunction --- phosphorylation --- non-sense mRNA decay --- mammalian target of rapamycin (mTOR) complex-1 --- duchenne muscular distrophy --- n/a