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Radiotherapy --- Hyperthermia, Induced --- Photochemotherapy --- Hemolysis --- Radiation-Sensitizing Agents --- radiation effects --- pharmacology

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Urinary Bladder --- Cisplatin --- Cyclophosphamide --- Radiation Injuries, Experimental --- Radiation-Sensitizing Agents --- Urodynamics --- radiation effects --- toxicity --- toxicity --- physiopathology --- toxicity --- drug effects

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Cancer chemotherapy can be traced back to the 1940’s and since then the world has witnessed the discovery and the important application of several new drugs. The successes of combination chemotherapy suggested that all cancers can be treated provided that the correct combination of drugs at the correct doses and correct intervals are established. However, with time, tumor cells develop mechanisms of resistance to apoptosis and no longer respond to the majority of cytotoxic therapies. Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy, edited by Benjamin Bonavida, reviews novel approaches developed to reverse tumor cell resistance to chemo/immuno/radio-therapy and the use of various sensitizing agents in combination with various cytotoxics. Such sensitizing agents target gene products that regulate resistance and therefore identify novel targets for drug development. This book also introduces several of the current approaches that have been developed by established investigators in the field that are aimed at overcoming resistance. This book is the first that compiles studies on tumor cell sensitization and is useful for students, scientists, clinicians and pharmaceutical companies.

Radiation-sensitizing agents. --- Drug resistance in cancer cells. --- Antineoplastic agents --- Effectiveness. --- Anticancer agents --- Antineoplastic drugs --- Antineoplastics --- Antitumor agents --- Antitumor drugs --- Cytotoxic drugs --- Inhibitors, Neoplasm --- Neoplasm inhibitors --- Drugs --- Cancer --- Antitumor drug resistance --- Cancer drug resistance --- Drug resistance in cancer --- Drug resistance in tumor cells --- Cancer cells --- Radiation --- Radiosensitizing agents --- Chemotherapy --- Sensitizing agents --- Oncology. --- Oncology  . --- Toxicology. --- Immunology. --- Cancer Research. --- Pharmacology/Toxicology. --- Immunobiology --- Life sciences --- Serology --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Tumors --- Toxicology --- Cancer research. --- Pharmacology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Pharmacy --- Cancer research --- Physiological effect

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Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers. Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology.

Cancer research. --- Radiotherapy. --- Pharmacology. --- Cancer Research. --- Pharmacology/Toxicology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Radiation therapy --- Electrotherapeutics --- Hospitals --- Medical electronics --- Medical radiology --- Therapeutics, Physiological --- Phototherapy --- Cancer research --- Physiological effect --- Radiological services --- Radiation-sensitizing agents. --- Radiation --- Radiosensitizing agents --- Sensitizing agents --- Farmacologia --- Investigació farmacèutica --- Oncologia --- Radiologia mèdica --- Radiologia clínica --- Radiologia (Medicina) --- Física mèdica --- Medicina nuclear --- Radiofàrmacs --- Radiografia mèdica --- Radiologia dental --- Radiologia intervencionista --- Radiologia pediàtrica --- Radiologia veterinària --- Radioteràpia --- Diagnòstic radiològic --- Medicina --- Oncologia geriàtrica --- Oncologia pediàtrica --- Oncologia veterinària --- Càncer --- Infermeria oncològica --- Tumors --- Investigació farmacològica --- Investigació de medicaments --- Recerca de medicaments --- Investigació mèdica --- Biofarmàcia --- Biotransformació (Metabolisme) --- Dermofarmacologia --- Desenvolupament de medicaments --- Estabilitat dels medicaments --- Farmacocinètica --- Farmacogenètica --- Farmacologia cardiovascular --- Farmacologia clínica --- Farmacologia dental --- Farmacologia geriàtrica --- Farmacologia molecular --- Farmacologia obstètrica --- Farmacologia ocular --- Farmacologia pediàtrica --- Farmacologia respiratòria --- Farmacologia renal --- Farmacologia veterinària --- Immunofarmacologia --- Isòtops radioactius en farmacologia --- Neurofarmacologia --- Psicofarmacologia --- Química farmacèutica --- Resistència als medicaments --- Toxicologia --- Medicaments --- Quimioteràpia --- Fotofarmacologia