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Rabies is the most current and comprehensive account of one of the oldest diseases known that remains a significant public health threat despite the efforts of many who have endeavored to control it in wildlife and domestic animals. During the past five years since publication of the first edition there have been new developments in many areas on the rabies landscape. This edition takes on a more global perspective with many new authors offering fresh outlooks on each topic. Clinical features of rabies in humans and animals are discussed as well as basic science aspects, molecular biology, pathology, and pathogenesis of this disease. Current methods used in defining geographic origins and animal species infected in wildlife are presented, along with diagnostic methods for identifying the strain of virus based on its genomic sequence and antigenic structure. This multidisciplinary account is essential for clinicians as well as public health advisors, epidemiologists, wildlife biologists, and research scientists wanting to know more about the virus and the disease it causes. * Offers a unique global perspective on rabies where dog rabies is responsible for killing more people than yellow fever, dengue fever, or Japanese encephalitis * More than 7 million people are potentially exposed to the virus annually and about 50,000 people, half of them children, die of rabies each year * New edition includes greatly expanded coverage of bat rabies which is now the most prominent source of human rabies in the New World and Western Europe, where dog rabies has been controlled * Recent successes of controlling wildlife rabies with an emphasis on prevention is discussed * Approximately 40% updated material incorporates recent knowledge on new approaches to therapy of human rabies as well as issues involving organ and tissue transplantation * Includes an increase in illustrations to more accurately represent this diseases' unique horror.

Rabies --- Rabies vaccines --- Rabies virus

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Human cell culture --- Rabies vaccines --- Rabies --- Congresses --- Congresses --- Vaccination --- Congresses

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Cet ouvrage résolument interdisciplinaire rassemble des études au croisement des sciences médicales, biologiques et humaines, et permet d'éclairer des aspects méconnus voire totalement inédits concernant la rage. Cette maladie continue de tuer environ 50 000 personnes par an dans le monde alors qu'il existe un vaccin très efficace s'il est administré à temps. L'ouvrage débute par des données sur la rage en tant que maladie puis se divise en trois grandes parties. Il fait la part belle à l'Antiquité gréco-romaine, analysée sous l'angle philologique ainsi qu'à travers deux corpus (plinien et galénique). Des prolongements sur des périodes plus récentes permettent ensuite de retracer sur 2000 ans les manifestations de la rage furieuse qui pourraient être à l'origine de la légende des lycanthropes ainsi que les évocations d'un remède rappelant le principe de la vaccination. Cela permet d'établir, après analyse de milliers d'attaques d'êtres humains en France, une distinction nette entre loups prédateurs et enragés. Enfin, l'ouvrage se conclut par la biographie et l'évocation des travaux de trois personnages oubliés de l'histoire de la rage : le vétérinaire lyonnais Pierre-Victor Galtier qui a ouvert la voie à Louis Pasteur, le médecin Charles Livon à l'origine du centre d'inoculation antirabique de Marseille, et le microbiologiste Léon Perdrix, collaborateur de Pasteur et doyen de la Faculté des sciences de Marseille.

Rabies virus --- Zoonoses. --- Rabies Vaccines --- Rabies --- Virus rabique. --- Zoonoses. --- Vaccin antirabique. --- Rage --- history. --- Histoire. --- Pasteur, Louis