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RNA, Ribosomal --- Colicins --- Escherichia coli --- Nucleic Acid Conformation --- genetics

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Adjuvants, Immunologic --- Quaternary Ammonium Compounds --- Listeria monocytogenes --- RNA, Ribosomal --- Listeriosis --- pharmacology --- pharmacology --- genetics --- immunology --- immunology

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This comprehensive and highly illustrated book provides a basic andup-to-date summary of translation on bacterial ribosomes, withemphasis on the structural insights. It is an attempt to present theribosome and its functional activities in a coherent manner.

Proteins --- Ribosomes --- Genetic translation. --- Translation (Genetics) --- Genetic code --- Genetic regulation --- Molecular structure --- Protein biosynthesis --- Protein synthesis --- Synthesis. --- Structure. --- Metabolism --- Bacterial Proteins --- RNA, Ribosomal --- Protein Synthesis Inhibitors --- Synthesis --- Structure --- physiology --- Proteins - Synthesis --- Ribosomes - Structure --- Proteins - physiology --- Bacterial Proteins - physiology --- RNA, Ribosomal - physiology --- Protein Synthesis Inhibitors - physiology

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The ribosome is a macromolecular machine that synthesizes proteins with a high degree of speed and accuracy. Our present understanding of its structure, function and dynamics is the result of six decades of research. This book collects over 40 articles based on the talks presented at the 2010 Ribosome Meeting, held in Orvieto, Italy, covering all facets of the structure and function of the ribosome. New high-resolution crystal structures of functional ribosome complexes and cryo-EM structures of translating ribosomes are presented, while partial reactions of translation are examined in structural and mechanistic detail, featuring translocation as a most dynamic process. Mechanisms of initiation, both in bacterial and eukaryotic systems, translation termination, and novel details of the functions of the respective factors are described. Structure and interactions of the nascent peptide within, and emerging from, the ribosomal peptide exit tunnel are addressed in several articles. Structural and single-molecule studies reveal a picture of the ribosome exhibiting the energy landscape of a processive Brownian machine. The collection provides up-to-date reviews which will serve as a source of essential information for years to come.

Ribosomes -- Congresses. --- Ribosomes -- Structure -- Congresses. --- Ribosomes. --- RNA, Ribosomal. --- Ribosomes --- Proteins --- RNA --- Metabolic Phenomena --- Organelles --- Phenomena and Processes --- Nucleic Acids --- Cytoplasmic Structures --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Cytoplasm --- Nucleic Acids, Nucleotides, and Nucleosides --- Intracellular Space --- Cellular Structures --- Cells --- Anatomy --- Metabolism --- RNA, Ribosomal --- Ribosomal Proteins --- Human Anatomy & Physiology --- Biology --- Health & Biological Sciences --- Cytology --- Physiology --- Structure --- Ribonucleoprotein particles --- Medicine. --- Gene expression. --- Nucleic acids. --- Biophysics. --- Biological physics. --- Biomedicine. --- Gene Expression. --- Nucleic Acid Chemistry. --- Biophysics and Biological Physics. --- Cell organelles --- Microsomes --- Nucleoproteins --- Protoplasm --- Biological and Medical Physics, Biophysics. --- Polynucleotides --- Biomolecules --- Genes --- Genetic regulation --- Expression --- Biological physics --- Medical sciences --- Physics --- Molecular genetics. --- Biomaterials. --- Molecular Genetics. --- Nucleic Acid. --- Genetics --- Molecular biology

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When quantum mechanics was first proposed a century ago, nobody could have anticipated how deeply it would affect our lives.  Today, we are connected and powered through devices whose existence is predicated on the basic principles of this strange physics.  Not even the biological sciences have escaped its reach.  As scientists query the deepest mysteries of the living world, the physical scales probed and the types of questions asked are increasingly blurring the lines between biology and physics.  The hybrid field of biophysics represents the new frontier of the 21st century. The ribosome has been at the heart of three Nobel Prizes.  Understanding its essential nature and how it interacts with other proteins and nucleic acids to control protein synthesis has been one of the central foundations in our understanding of the biology at the molecular level.  With the advent of atomic scale structures, methods to visualize and separate individual molecules, and the computational power to model the complex interactions of over a million atoms at once, our understanding of how gene expression is controlled at the level of protein translation is now deeply ensconced in the biophysical realm. This book provides a premier resource to a wide audience, whether it be the general reader seeking a broad view of the field, a clinician interested in the role of protein translation in human disease, the bench researcher looking for state-of-the-art technologies, or computational scientists involved in cutting edge molecular modeling.

Biophysics. --- Gene expression regulation. --- Genetic engineering. --- Genetic regulation. --- Genetic regulation --- Physical biochemistry --- Biological Science Disciplines --- Genetic Processes --- RNA --- Physical Phenomena --- Organelles --- Nucleic Acids --- Genetic Phenomena --- Phenomena and Processes --- Cytoplasmic Structures --- Natural Science Disciplines --- Cytoplasm --- Disciplines and Occupations --- Nucleic Acids, Nucleotides, and Nucleosides --- Chemicals and Drugs --- Intracellular Space --- Cellular Structures --- Cells --- Anatomy --- RNA, Ribosomal --- Physiology --- Gene Expression --- Biophysical Phenomena --- Ribosomes --- Biology --- Human Anatomy & Physiology --- Health & Biological Sciences --- Genetics --- Gene expression. --- Genetic translation. --- Physical biochemistry. --- Biophysical chemistry --- Translation (Genetics) --- Genes --- Expression --- Medicine. --- Biochemistry. --- Nucleic acids. --- Biomedicine. --- Gene Expression. --- Biological and Medical Physics, Biophysics. --- Biochemistry, general. --- Nucleic Acid Chemistry. --- Crystallography and Scattering Methods. --- Biochemistry --- Physical organic chemistry --- Genetic code --- Crystallography. --- Leptology --- Physical sciences --- Mineralogy --- Polynucleotides --- Biomolecules --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Composition --- Biological physics. --- Biological physics --- Physics