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Reoviridae Infections --- Reoviridae --- Reoviruses. --- Etiology. --- Pathogenicity.

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Reoviruses are one of the most important viral groups for understanding the molecular and genetic basis for viral pathogenesis. These two volumes cover virtually all aspects of reovirus biology. Volume I begins with a review of reovirus structure; further chapters deal with functions of the reovirus structural proteins, the assembly of the genome, and reovirus mutants. Volume II reviews general mechanisms of reovirus persistent infection and cytopathic effects, and then discusses reovirus-induced disease in specific organ systems including the heart, nervous and endocrine systems, liver and biliary system, and intestine. Together, these two volumes provide a current and comprehensive review of the mammalian reoviruses.

Reoviridae --- Reoviruses --- Reovirussen --- Réovirus --- Virus [Réo] --- Viruses [Reo] --- Virussen [Reo] --- Reoviridae Infections --- physiology --- virology --- Reoviruses. --- physiology. --- virology. --- Physiology. --- Virology. --- Microbiology. --- Medical microbiology. --- Medical Microbiology. --- Microbial biology --- Biology --- Microorganisms --- Microbiology --- Viruses. --- Genetic vectors --- Mobile genetic elements --- Extrachromosomal DNA

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Reoviridae family members are large, complex viruses that infect human, animals, plants and insects. They are unique in that they lack lipid envelopes and package their genomes of discrete double-stranded segments of RNA within multi-layered capsids. Lack of a lipid envelope has allowed three-dimensional structures of these large complex viruses to be obtained. The capsids of these viruses undergo cell entry, uncoating, the enzymatic functions necessary for transcription of the genome, and are later involved in egress from host cells. Recent years have seen an increase in our knowledge of the structure of these viruses coupled with substantial progress in unravelling the molecular details of these processes. Intriguingly, despite their diversity in hosts, structures and modes of transmission, striking parallels have emerged in the molecular interactions necessary for the essential processes of virus entry, assembly and release. This book reviews our current understanding of Reoviridae entry, disassembly/assembly and egress in addition to updating high resolution structures of viral proteins and capsids from three different genera of the family.

Reoviruses. --- Microbiology. --- Microbial biology --- Biology --- Microorganisms --- Reoviridae --- Respiratory enteric orphan viruses --- RNA viruses --- Medical virology. --- Virology. --- Medical microbiology --- Virology --- Virus diseases --- Microbiology