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Endothelial Growth Factors --- Lymphokines --- Osteoblasts --- Receptors, Growth Factor --- biosynthesis --- biosynthesis --- physiology --- biosynthesis

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Historically, the field of hematopoietic growth factor research began with the work of Carnot and Deflandre-in 1906 they suggested that the rate of erythropoiesis is regulated by a humoral factor found in the blood, namely, erythropoietin. From this comparatively early start, accelerating progress has been made in erythropoietin research, which demon­ strates the general trends in this field of study. Erythropoietin was purified to homogeneity by 1977 (from enormous quantities of urine from aplastic anemia patients). Subsequently, the gene for erythropoietin has been cloned (1985), and massive quantities of this growth factor have been produced for clinical trials (late 1980s onward). Erythropoietin has become established as a pharmaceutical product of great value in the treatment of a number of diseases, most notably chronic renal failure. Once the ligand had been cloned, interest turned to the erythropoietin receptor, which was cloned in 1989. Since then, structure/ function studies have been performed on receptor mutants, cellular signaling events down­ stream from the occupied receptor have been identified, and the specific producer cell types and molecular stimuli for erythropoietin production have been thoroughly investigated, as has the regulation of erythropoietin gene transcription. This schedule of events since the 1970s typifies that seen for a number of hematopoietic growth factors. Along the way, the hematopoietic growth factors have been recognized as members of the cytokine family of signaling molecules that are important in a number of different physiological and patholog­ ical situations (see below).

Hematopoietic Cell Growth Factors --- Receptors, Growth Factor --- Blood Cells --- Erythropoietin --- Blood cells --- Hematopoietic growth factors. --- Erythropoïétine --- physiology. --- therapeutic use. --- immunology. --- immunology --- Biochemistry. --- Cell Biology. --- 57 --- Cellular Biology --- Cytology --- Biologies, Cell --- Biologies, Cellular --- Biology, Cell --- Biology, Cellular --- Cell Biologies --- Cellular Biologies --- Biological sciences in general --- Periodicals --- Health Sciences --- Physiology --- Biochemistry --- Cell Biology --- Oncology  . --- Hematology. --- Immunology. --- Human genetics. --- Oncology. --- Biochemistry, general. --- Human Genetics. --- Blood cells.

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The enormity of the literature on growth factors, plus the breadth of the biological disciplines and technical expertise required prohibits a comprehensive review by even a multi-disciplinary panel of authors. To provide an alternative that is feasible for authors and digestible by readers, this review compendium consists of a collection of articles, each covering an aspect of teh ErbB/EGF field. This compilation features articles on growth factor ligands, neuregulins, and individual receptors. The second part of the book concentrates on the biological context of the ErbB receptors, particular

Epidermal growth factor. --- Neoplasms. --- Receptor, Epidermal Growth Factor. --- Tumors. --- Receptors, Growth Factor --- Diseases --- Receptor Protein-Tyrosine Kinases --- Receptors, Gastrointestinal Hormone --- Protein-Tyrosine Kinases --- Receptors, Peptide --- Receptors, Cell Surface --- Protein Kinases --- Membrane Proteins --- Proteins --- Phosphotransferases (Alcohol Group Acceptor) --- Phosphotransferases --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Transferases --- Enzymes --- Enzymes and Coenzymes --- Receptor, Epidermal Growth Factor --- Neoplasms --- Medicine --- Health & Biological Sciences --- Oncology --- Tumors --- Epidermal growth factor --- Growth. --- Receptors. --- Anthelone --- EGF (Growth factor) --- EGF-URO (Growth factor) --- EGF-Urogastrone --- Epidermal growth factor-Urogastrone --- Uroanthelone --- Uroenterone --- Cancer --- Neoplasm growth --- Tumor growth --- Growth --- Growth factors

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The placenta is an organ that connects the developing fetus to the uterine wall, thereby allowing nutrient uptake, waste elimination, and gas exchange via the mother's blood supply. Proper vascular development in the placenta is fundamental to ensuring a healthy fetus and successful pregnancy. This book provides an up-to-date summary and synthesis of knowledge regarding placental vascular biology and discusses the relevance of this vascular bed to the functions of the human placenta.

Fetal stem cells -- Physiology. --- Placental circulation -- Physiology. --- Trophoblasts -- Physiology. --- Blastocyst --- Stem Cells --- Placenta --- Receptor Protein-Tyrosine Kinases --- Blood Circulation --- Endocrine Cells --- Receptors, Growth Factor --- Embryonic Structures --- Protein-Tyrosine Kinases --- Cells --- Embryo, Mammalian --- Receptors, Cell Surface --- Receptors, Peptide --- Cardiovascular Physiological Processes --- Anatomy --- Membrane Proteins --- Protein Kinases --- Cardiovascular Physiological Phenomena --- Proteins --- Circulatory and Respiratory Physiological Phenomena --- Phosphotransferases (Alcohol Group Acceptor) --- Fetal Stem Cells --- Trophoblasts --- Receptors, Vascular Endothelial Growth Factor --- Placental Circulation --- Phosphotransferases --- Amino Acids, Peptides, and Proteins --- Phenomena and Processes --- Transferases --- Chemicals and Drugs --- Enzymes --- Enzymes and Coenzymes --- Human Anatomy & Physiology --- Zoology --- Health & Biological Sciences --- Physiology --- Animal Anatomy & Embryology --- Blood-vessels. --- blood supply. --- placenta circulation --- trophoblast --- angiogenesis --- vasoactivity --- placental stem cells

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Granulocyte colony-stimulating factor (G-CSF or GCSF) is a secreted glycoprotein that stimulates the proliferation and differentiation of granulocyte precursor cells, and induces mobilization of peripheral blood progenitor cells from the bone marrow. Development of recombinant human G-CSF has had a profound impact on the treatment of many diseases, including severe chronic neutropenia and cancer, and has enabled peripheral stem cell transplantation to supplant bone marrow transplantation in the autologous setting. This Milestones in Drug Therapy volume describes the experience of the last 20 years of treatment with recombinant human G-CSF, including the basic science, the use of recombinant human G-CSF in both the oncology and nononcology settings, and the safety and economics of its use. Many of the authors were the original investigators of recombinant human G-CSF and other authors are key researchers who provide their outlook for the next 20 years for use of and research with recombinant human G-CSF.

Drug abuse -- Etiology -- Handbooks, manuals, etc. --- Drug abuse -- Psychological aspects -- Handbooks, manuals, etc. --- Filgrastim --- Colony-Stimulating Factors --- Leukemia --- Neoplasms, Plasma Cell --- Receptors, Colony-Stimulating Factor --- Lymphoproliferative Disorders --- Hematologic Diseases --- Hemostatic Disorders --- Therapeutics --- Paraproteinemias --- Hemorrhagic Disorders --- Hematopoietic Cell Growth Factors --- Receptors, Cytokine --- Immunoproliferative Disorders --- Neoplasms by Histologic Type --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Receptors, Growth Factor --- Hemic and Lymphatic Diseases --- Blood Protein Disorders --- Glycoproteins --- Vascular Diseases --- Cytokines --- Proteins --- Receptors, Peptide --- Neoplasms --- Receptors, Immunologic --- Diseases --- Immune System Diseases --- Cardiovascular Diseases --- Receptors, Cell Surface --- Amino Acids, Peptides, and Proteins --- Intercellular Signaling Peptides and Proteins --- Membrane Proteins --- Chemicals and Drugs --- Biological Factors --- Peptides --- Multiple Myeloma --- Granulocyte Colony-Stimulating Factor --- Drug Therapy --- Leukocyte Disorders --- Leukemia, Myeloid --- Receptors, Granulocyte Colony-Stimulating Factor --- Health & Biological Sciences --- Biology --- Pharmacy, Therapeutics, & Pharmacology --- Microbiology & Immunology --- Granulocyte-macrophage colony-stimulating factor. --- Colony-stimulating factors (Physiology) --- Granulocytes. --- Macrophages. --- Histiocytes --- Mononuclear phagocytes --- Granular leucocytes --- CSF-GM (Colony-stimulating factor) --- GM-CSF (Colony-stimulating factor) --- Histamine-producing cell-stimulating factor --- Medicine. --- Cancer research. --- Immunology. --- Pharmacology. --- Hematology. --- Cytokines. --- Growth factors. --- Biomedicine. --- Pharmacology/Toxicology. --- Cancer Research. --- Cytokines and Growth Factors. --- Antigen presenting cells --- Connective tissue cells --- Killer cells --- Phagocytes --- Reticulo-endothelial system --- Leucocytes --- Hematopoietic growth factors --- Toxicology. --- Oncology. --- Haematology --- Internal medicine --- Blood --- Cellular immunity --- Immune response --- Immunobiology --- Life sciences --- Serology --- Tumors --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Regulation --- Toxicology --- Cell growth factors --- Cellular growth factors --- Growth peptides --- Growth promoting substances --- Growth substances --- Peptide growth factors --- Peptide regulatory factors --- Polypeptide growth factors --- Cancer research --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect