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This book focuses on the Genian quadruplets, all of whom were schizophrenic. The book could have been written in many ways. The case history material could have been presented by themes or topics, such as intrafamilial relationships, sexuality, dependency, and so on. Or each quadruplet could have been traced separately, with a later attempt to interrelate the separate histories. But I have decided to present the material chronologically with respect to the family as a unit, trying to recapture the coursing problems, moods, assumptions, and decisions which beset the family members over the years and which eventually entangled them together in a net of circumstances that tightened more and more around each as they struggled to free themselves from it. Since six persons are involved, it is necessary in such a presentation to focus now on one, now on another, in a sense moving the spotlight where the family itself has directed. This may at times make the presentation appear jumpy and uneven, but hopefully it mirrors what actually occurred. The case history comprises the first part of the book. The second part presents tests and studies dealing with some basic characteristics and response processes. The third section consists of various protective tests and their analyses. The fourth involves systematic analyses of observations of the family by NIH staff and by the community. Part five presents some conceptualizations of family members and their interrelationships. Finally, I have presented a theoretical analysis of the heredity-environment problem in schizophrenia, summarizing the basic issues that apply to the Genains and our current knowledge about those issues, and indicating how this study illuminates them. (PsycINFO Database Record (c) 2017 APA, all rights reserved).
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"Therapeutic applications of quadruplex nucleic acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics"--P. [4] of cover.
Quadruplex nucleic acids --- Therapeutic use. --- G-quadruplexes --- G-tetrads --- Guanine quadruplexes --- Tetraplex nucleic acids --- Nucleic acids
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Quadruplex nucleic acids. --- G-quadruplexes --- G-tetrads --- Guanine quadruplexes --- Tetraplex nucleic acids --- Nucleic acids
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Gaining Insights into the Small Molecule Targeting of the G-Quadruplex in the c-MYC Promoter Using NMR and an Allele-Specific Transcriptional Assay, by Christine E. Kaiser, Vijay Gokhale, Danzhou Yang and Laurence H. Hurley.- Higher-Order Quadruplex Structures, by Luigi Petraccone.- Investigation of Quadruplex Structure Under Physiological Conditions Using In-Cell NMR, by Robert Hänsel, Silvie Foldynová-Trantírková, Volker Dötsch and Lukás Trantírek.- Circular Dichroism of Quadruplex Structures, by Antonio Randazzo, Gian Piero Spada and Mateus Webba da Silva.- Molecular Crowding and Hydration Regulating of G-Quadruplex Formation, by Daisuke Miyoshi, Takeshi Fujimoto and Naoki Sugimoto.- Visualizing the Quadruplex: From Fluorescent Ligands to Light-Up Probes, by Eric Largy, Anton Granzhan, Florian Hamon, Daniela Verga and Marie-Paule Teulade-Fichou.- Calculation of Hydrodynamic Properties for G-Quadruplex Nucleic Acid Structures from in silico Bead Models, by Huy T. Le, Robert Buscaglia, William L. Dean, Jonathan B. Chaires and John O. Trent.- Energetics of Ligand Binding to G-Quadruplexes, Concetta Giancola and Bruno Pagano.- Tetramolecular Quadruplex Stability and Assembly, by Phong Lan Thao Tran, Anne De Cian, Julien Gros, Rui Moriyama and Jean-Louis Mergny.
Quadruplex nucleic acids --- Chemistry --- Physical Sciences & Mathematics --- Organic Chemistry --- G-quadruplexes --- G-tetrads --- Guanine quadruplexes --- Tetraplex nucleic acids --- Chemistry. --- Bioorganic chemistry. --- Medical biochemistry. --- Nucleic acids. --- Biophysics. --- Biological physics. --- Bioorganic Chemistry. --- Nucleic Acid Chemistry. --- Medical Biochemistry. --- Biophysics and Biological Physics. --- Quadruplex nucleic acids. --- Nucleic acids --- Biochemistry. --- Biological and Medical Physics, Biophysics. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Polynucleotides --- Biomolecules --- Bio-organic chemistry --- Biological organic chemistry --- Biochemistry --- Chemistry, Organic --- Composition --- Biological physics --- Physics --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Pathology
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Guanine rich DNA has been known for decades to form unusual structures, although their biological relevance was little understood. Recent advances have demonstrated that quadruplex structures can play a role in gene expression and provide opportunities for a new class of anticancer therapeutics. A number of quadruplex-specific proteins have also been discovered. Quadruplex Nucleic Acids discusses all aspects of the fundamentals of quadruplex structures, including their structure in solution and the crystalline state, the kinetics of quadruplex folding, and the role of cations in structure and
Molecular pharmacology --- Molecular biology --- Pharmacologie moléculaire --- Biologie moléculaire --- Quadruplex nucleic acids --- Nucleic Acid Conformation --- DNA --- Genetic Structures --- Nucleic Acids --- Molecular Conformation --- Genetic Phenomena --- Nucleic Acids, Nucleotides, and Nucleosides --- Molecular Structure --- Chemicals and Drugs --- Biochemical Phenomena --- Phenomena and Processes --- Chemical Phenomena --- Animal Biochemistry --- Human Anatomy & Physiology --- Health & Biological Sciences --- Pharmacologie moléculaire --- Biologie moléculaire
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