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While the utilization of microarrays for gene expression studies has been widely published, Microarray Methods for Drug Discovery describes the use of this technology for a multitude of other vital applications. Covering the field of drug discovery through its various aspects, including high throughput screening, target identification, drug metabolism and toxicity screening as well as clinical sample handling, this volume also addresses new emerging fields like miRNA profiling, ribonomic and glycomic profiling. All chapters, contributed by experts in the field, follow the highly successful Methods in Molecular Biology™ series format, which is comprised of brief introductions, lists of required materials and reagents, readily reproducible, step-by-step lab protocols, along with detailed tips on troubleshooting and avoiding known pitfalls, making this book an easy read for investigators at all levels of expertise. Authoritative and cutting-edge, Microarray Methods for Drug Discovery provides an ideal desk reference for scientists who wish to use microarray technology in order to better understand a variety of biological interactions in their respective fields.
Toxicology. --- Human genetics. --- Pharmacology/Toxicology. --- Human Genetics. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Toxicology --- Microarrays --- Genètica molecular --- Química farmacèutica --- Farmacoquímica --- Química dels medicaments --- Química mèdica --- Química patològica --- Química terapèutica --- Farmàcia --- Farmacologia --- Química --- Matèria mèdica --- Medicaments --- Química combinatòria --- Biologia molecular --- Genètica --- Clonatge molecular --- Codi genètic --- Elements genètics mòbils --- Genètica bioquímica --- Genètica molecular humana --- Genètica molecular vegetal --- Genòmica --- Gens --- Regulació genètica --- Variació en el nombre de còpies --- Bioxips --- Microarray
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Química farmacèutica --- Indústria farmacèutica --- Optimització matemàtica --- Mètodes de simulació --- Jocs d'estratègia (Matemàtica) --- Optimització combinatòria --- Programació dinàmica --- Programació (Matemàtica) --- Anàlisi de sistemes --- Empreses farmacèutiques --- Indústria química --- Farmàcies --- Utilització de medicaments --- Indústria cosmètica --- Farmacoquímica --- Química dels medicaments --- Química mèdica --- Química patològica --- Química terapèutica --- Farmàcia --- Farmacologia --- Química --- Matèria mèdica --- Medicaments --- Química combinatòria --- Chemistry --- Pharmaceutical industry. --- Philosophy. --- Drug industry --- Drug trade --- Medicine industry --- Medicines industry --- Prescription medicine industry --- Chemical industry
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Chemistry --- Pharmaceutical industry. --- Philosophy. --- Drug industry --- Drug trade --- Medicine industry --- Medicines industry --- Prescription medicine industry --- Chemical industry --- Química farmacèutica --- Indústria farmacèutica --- Optimització matemàtica --- Mètodes de simulació --- Jocs d'estratègia (Matemàtica) --- Optimització combinatòria --- Programació dinàmica --- Programació (Matemàtica) --- Anàlisi de sistemes --- Empreses farmacèutiques --- Indústria química --- Farmàcies --- Utilització de medicaments --- Indústria cosmètica --- Farmacoquímica --- Química dels medicaments --- Química mèdica --- Química patològica --- Química terapèutica --- Farmàcia --- Farmacologia --- Química --- Matèria mèdica --- Medicaments --- Química combinatòria
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This volume explores detailed methods and experimental protocols evaluating the effect of a compound or a mixture of compounds on the action of enzymes that are significant targets in pharmaceuticals. Consisting of three sections, the book delves into recent biocomputing and bioinformatics protocols, state-of-the art modern biophysical, electrophoretic, and chromatographic methods and high-throughput screening approaches, as well as detailed protocols and examples of the inhibition analysis and evaluation of selected enzymes. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Targeting Enzymes for Pharmaceutical Development: Methods and Protocols serves as a vital reference for academics and industry professionals working on expanding our understanding of the wide range of important enzyme targets. The chapter “Enzyme–Ligand Interaction Monitored by Synchrotron Radiation Circular Dichroism” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Enzims --- Farmacologia molecular --- Biologia molecular --- Farmacologia --- Biocatalitzadors --- Ferments --- Catalitzadors --- Proteïnes --- Coenzims --- Enzims al·lostèrics --- Enzims microbians --- Fibrinolítics --- Hidrolases --- Iduronat-2-sulfatasa --- Inducció enzimàtica --- Isoenzims --- Malt --- Metal·loenzims --- Oxidoreductases --- Transferases --- Biocatàlisi --- Fermentació --- Pharmaceutical chemistry. --- Enzymology. --- Medicinal chemistry. --- Pharmaceutics. --- Medicinal Chemistry. --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Chemistry --- Biochemistry --- Enzymes --- Enzimologia --- Bioquímica clínica --- Química farmacèutica --- Farmacoquímica --- Química dels medicaments --- Química mèdica --- Química patològica --- Química terapèutica --- Farmàcia --- Química --- Matèria mèdica --- Medicaments --- Química combinatòria --- Bioquímica de les malalties --- Bioquímica mèdica --- Bioquímica patològica --- Patobioquímica --- Bioquímica --- Bioquímica clínica veterinària --- Química clínica --- Enzimologia clínica
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This book provides a comprehensive discussion on the current information and evidence on the latest developments in the field of drugs resistance. Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in treating a disease or condition. This leads to negative outcomes at great risk of public health; therefore, increasing efforts are dedicated to the development of a new generation of medications that will help deal with this phenomenon. Decades of technological innovations in drug design have demonstrated the potential of resistance. Enormous information on various aspects of antibiotics resistance is available. However, literature on drug resistance specifically related to infectious and non-infectious diseases is rarely presented, particularly those focusing on the mechanisms, biochemistry, kinetics, dynamics, and management of drug resistance. Therefore, there is an immense need for a systematic compilation on the available information about this issue. All the chapters are logically selected and arranged to provide state-of-the-art information about all aspects of drugs resistance. After an introductory chapter, four chapters are dedicated to infectious microbial diseases, whereas two other chapters are complimenting this theme and focusing on drugs resistance in ear, nose and throat, and skin diseases. The recent advances in the understanding of drugs resistance in lung, neurological, kidney, heart, and liver diseases are also covered. Biochemistry of drugs resistance in cancer, HIV, ocular, reproductive, and diabetes diseases is also discussed. Finally, a chapter dedicated to the “management of drug resistance” has been included. .
Drug resistance. --- Laboratory medicine. --- Pharmacology. --- Cancer research. --- Biomedical engineering. --- Drug Resistance. --- Laboratory Medicine. --- Pharmacology/Toxicology. --- Cancer Research. --- Biomedical Engineering/Biotechnology. --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Cancer research --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Clinical medicine --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Diagnosis --- Pathology --- Resistance to drugs --- Pharmacology --- Physiological effect --- Pharmaceutical chemistry --- Technique. --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Chemistry --- Resistència als medicaments --- Química farmacèutica --- Farmacoquímica --- Química dels medicaments --- Química mèdica --- Química patològica --- Química terapèutica --- Farmàcia --- Farmacologia --- Química --- Matèria mèdica --- Medicaments --- Química combinatòria --- Farmacoresistència --- Resistència a la insulina --- Efecte dels medicaments sobre els microorganismes
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Polymer Journal is the official journal of the Society of Polymer Science, Japan (SPSJ) and promotes research from all aspects of polymer science from anywhere in the world, The journal aims to provide an integrated platform for scientific communication that assists the advancement of polymer science and related fields.
Polymers --- Polymerization --- Polymères --- Polymerization. --- Polymers. --- Polymere --- Polymeride --- Macromolecules --- Polymerisation --- Synthesis of polymers --- Chemical reactions --- Polymers and polymerization --- Synthesis --- Chemistry --- Bioorganic chemistry --- Biomaterials --- Materials --- Thin films --- Chemistry/Food Science, general --- Polymer Sciences --- Surfaces and Interfaces, Thin Films --- Bioorganic Chemistry --- Surfaces --- Films, Thin --- Solid film --- Solid state electronics --- Solids --- Surfaces (Technology) --- Coatings --- Thick films --- Surface phenomena --- Friction --- Surfaces (Physics) --- Tribology --- Biocompatible materials --- Medical materials --- Medicine --- Biomedical engineering --- Biocompatibility --- Prosthesis --- Bio-organic chemistry --- Biological organic chemistry --- Biochemistry --- Chemistry, Organic --- Physical sciences --- Bioartificial materials --- Hemocompatible materials --- Biomaterials (Biomedical materials) --- Polimerització. --- Polímers. --- Síntesi orgànica. --- Química sintètica --- Química sintètica orgànica --- Síntesi de compostos orgànics --- Síntesi dels compostos orgànics --- Síntesi orgànica (Química) --- Síntesi (Química) --- Química combinatòria --- Síntesi de l'ADN --- Síntesi en fase sólida --- Compostos macromoleculars --- Polímers orgànics --- Polímers sintètics --- Macromolècules --- Biopolímers --- Copolímers --- Elastòmers --- Fluoropolímers --- Làtex sintètic --- Oligòmers --- Poliestirè --- Polímers conductors --- Polímers hidrosolubles --- Polímers ignífugs --- Polímers inorgànics --- Poliuretans --- Reaccions químiques --- Reacció en cadena de la polimerasa
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