Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The Protein Reviews series serves as a publication vehicle for reviews that focus on crucial contemporary and vital aspects of protein structure, function, evolution and genetics. Volume 20, Purinergic Receptors, has ten chapters. The first five chapters deal with various aspects of membrane binding. The first chapter focuses on the phox-homology (PX) domain, which is a phosphoinositide-binding domain conserved in all eukaryotes and present in forty-nine human proteins. The next chapter deals with the modeling of PH domains/phosphoinositides interactions. This is followed by a chapter on BAR domain proteins regulate Rho GTPase signaling. The BAR (Bin–Amphiphysin–Rvs) domain is a membrane lipid binding domain present in a wide variety of proteins, often proteins with a role in Rho-regulated signaling pathways. The fourth article presents AP180 N-terminal homology (ANTH) and Epsin N-terminal homology (ENTH) domains and discusses their physiological functions and involvement in disease. The fifth article reviews the polyphosphoinositide-binding domains and presents insights from peripheral membrane and lipid-transfer proteins. This is followed by a chapter on the physiological functions of phosphoinositide-modifying enzymes and their interacting proteins in Arabidopsis, then by a chapter on the molecular mechanisms of Vaspin action in various tissues such as adipose tissue, skin, bone, blood vessels, and the brain. The eighth chapter deals with exceptionally selective substrate targeting by the metalloprotease anthrax lethal factor followed by an article on Salmonella, E. coli, and Citrobacter type III secretion system effector proteins that alter host innate immunity. The last chapter presents New techniques to study intracellular receptors in living cells, with insights into RIG-I-like receptor signaling. Volume 20 is intended for research scientists, clinicians, physicians and graduate students in the fields of biochemistry, cell biology, molecular biology, immunology and genetics.

Proteins . --- Protein Structure. --- Purines --- Receptors. --- Purine receptors --- Purinergic receptors --- Purinoreceptors --- Cell receptors --- Proteids --- Biomolecules --- Polypeptides --- Proteomics

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Purines --- Receptors, Purinergic --- Signal Transduction --- Receptors --- Physiological effect --- Récepteurs --- Effets physiologiques --- Physiological effect. --- Receptors. --- Purine receptors --- Purinergic receptors --- Purinoreceptors --- Récepteurs --- Cell receptors --- Uric acid --- Receptor Mediated Signal Transduction --- Signal Transduction Pathways --- Signal Transduction Systems --- Receptor-Mediated Signal Transduction --- Signal Pathways --- Pathway, Signal --- Pathway, Signal Transduction --- Pathways, Signal --- Pathways, Signal Transduction --- Receptor-Mediated Signal Transductions --- Signal Pathway --- Signal Transduction Pathway --- Signal Transduction System --- Signal Transduction, Receptor-Mediated --- Signal Transductions --- Signal Transductions, Receptor-Mediated --- System, Signal Transduction --- Systems, Signal Transduction --- Transduction, Signal --- Transductions, Signal --- Cell Communication --- Receptor-CD3 Complex, Antigen, T-Cell --- Receptor Cross-Talk --- Feedback, Physiological --- Gasotransmitters --- Purine Receptor --- Purinoceptor --- Receptors, Methyladenine --- Receptors, Purine --- Methyladenine Receptors --- Purine Receptors --- Purinergic Receptors --- Purinoceptors --- Receptor, Purine --- Cell Signaling --- Animal Biochemistry --- Purinergic Receptor --- Receptor, Purinergic --- Receptors, Purinergic. --- Signal Transduction. --- Health Sciences --- Life Sciences --- Neurology --- Physiology --- Cytology, Cell Biology --- Micro and Molecular Biology

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

We proudly present the first book to integrate all aspects of purinergic signaling in the respiratory system. The first chapters introduce basic notions of purinergic pharmacology and metabolism, which allows readers from all scientific backgrounds to fully grasp the importance of these signaling networks for airway defenses, including mucociliary clearance and inflammatory responses. Then, chapters are devoted to the groundbreaking discovery that chronic respiratory diseases, including asthma, cystic fibrosis and chronic obstructive pulmonary disease (COPD), present specific aberrances in purinergic signaling which essentially drive lung complications. The last chapters describe the animal models used to investigate purinergic signaling in respiratory diseases, and the therapeutic applications developed by the pharmaceutical industry based on receptor agonists/antagonists and metabolic correctors. This highly comprehensive manuscript constitutes an invaluable tool for beginners and experts to follow the rapidly evolving research field of purinergic signaling. Furthermore, the critical analysis of past clinical protocols should facilitate the identification of potent therapeutic targets, and provide a better understanding of the data acquired in current clinical trials.

Purines -- Receptors. --- Respiratory organs -- Diseases. --- Respiratory Tract Diseases. --- Respiratory organs --- Purines --- Cellular signal transduction --- Anatomy --- Receptors, Cell Surface --- Diseases --- Biochemical Processes --- Receptors, Neurotransmitter --- Cell Physiological Processes --- Receptors, G-Protein-Coupled --- Biochemical Phenomena --- Membrane Proteins --- Chemical Processes --- Cell Physiological Phenomena --- Phenomena and Processes --- Chemical Phenomena --- Proteins --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Respiratory Tract Diseases --- Respiratory System --- Receptors, Purinergic --- Signal Transduction --- Medicine --- Health & Biological Sciences --- Respiratory System Diseases --- Receptors --- Respiratory infections. --- Receptors. --- Purine receptors --- Purinergic receptors --- Purinoreceptors --- Respiratory tract infections --- Upper respiratory infections --- Upper respiratory tract infections --- Air passages (Anatomy) --- Respiratory system --- Infections --- Medicine. --- Pharmaceutical technology. --- Infectious diseases. --- Metabolic diseases. --- Traumatology. --- Biomedicine. --- Biomedicine general. --- Pneumology/Respiratory System. --- Pharmaceutical Sciences/Technology. --- Metabolic Diseases. --- Infectious Diseases. --- Traumatic Surgery. --- Diseases. --- Cell receptors --- Infection --- Cardiopulmonary system --- Pneumology. --- Emerging infectious diseases. --- Trauma. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Disorders of metabolism --- Metabolic diseases --- Metabolic disorders --- Metabolism, Disorders of --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Respiratory organs—Diseases. --- Biomedicine, general. --- Accident medicine --- Trauma medicine --- Emergency medicine --- Surgery --- Wounds and injuries --- Biology --- Pharmaceutical chemistry. --- Surgery. --- Biomedical Research. --- Pharmaceutics. --- General Surgery. --- Research. --- Surgery, Primitive --- Human beings --- Illness --- Illnesses --- Morbidity --- Sickness --- Sicknesses --- Epidemiology --- Health --- Sick --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Chemistry --- Respiratory diseases --- Biological research --- Biomedical research