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An up-to-date reference on this fascinating set of complex disorders, this book features the most comprehensive strategies for diagnosing, classifying, imaging, treating, and managing amyloidosis in multiple organ systems. Beneficial to the spectrum of practitioners from residents to sub-specialists, this book is a succinct authoritative text written by leaders in the field. The authors provide instruction on all forms of amyloidosis - including primary amyloidosis (AL), secondary amyloidosis (AA), and familial amyloidosis. With essential treatment algorithms, Amyloidosis: Diagnosis and Treatment is the gold-standard for all hematologists, oncologists, and internists caring for patients with this disease.

Amyloid. --- Amyloidosis. --- Amyloidosis --- Natural Science Disciplines --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Proteins --- Multiprotein Complexes --- Proteostasis Deficiencies --- Amino Acids, Peptides, and Proteins --- Macromolecular Substances --- Metabolic Diseases --- Disciplines and Occupations --- Amyloid --- Diagnosis --- Chemistry --- Nutritional and Metabolic Diseases --- Chemicals and Drugs --- Diseases --- Medicine --- Health & Biological Sciences --- Pathology --- Treatment --- Diagnosis. --- Treatment. --- Amyloid degeneration --- Medicine. --- Internal medicine. --- Hematology. --- Medicine & Public Health. --- Internal Medicine. --- Lymphoproliferative disorders --- Metabolism --- Disorders --- Haematology --- Internal medicine --- Blood --- Medicine, Internal

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Life is produced by the interplay of water and biomolecules. This book deals with the physicochemical aspects of such life phenomena produced by water and biomolecules, and addresses topics including "Protein Dynamics and Functions", "Protein and DNA Folding", and "Protein Amyloidosis". All sections have been written by internationally recognized front-line researchers. The idea for this book was born at the 5th International Symposium "Water and Biomolecules", held in Nara city, Japan, in 2008.

Amyloidosis --Genetics. --- Nervous system --Degeneration --Genetics. --- Protein folding. --- Water chemistry. --- Protein folding --- Amyloidosis --- Nervous system --- Water chemistry --- Chemistry --- Protein Folding --- Genetics --- Water --- Neurodegenerative Diseases --- Nervous System Diseases --- Oxides --- Biology --- Biochemical Processes --- Proteostasis Deficiencies --- Natural Science Disciplines --- Biophysical Processes --- Hydroxides --- Physical Processes --- Biochemical Phenomena --- Inorganic Chemicals --- Biophysical Phenomena --- Metabolic Diseases --- Biological Science Disciplines --- Oxygen Compounds --- Diseases --- Chemical Processes --- Disciplines and Occupations --- Nutritional and Metabolic Diseases --- Chemicals and Drugs --- Chemical Phenomena --- Physical Phenomena --- Phenomena and Processes --- Animal Biochemistry --- Biology - General --- Human Anatomy & Physiology --- Health & Biological Sciences --- Degeneration --- Biomolecules. --- Water. --- Biological molecules --- Life sciences. --- Proteomics. --- Life Sciences. --- Life Sciences, general. --- Hydrology --- Molecules --- Molecular biology --- Proteins --- Biosciences --- Sciences, Life --- Science

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Reviews the molecular events initiated by unfolded or misfolded proteins leading to conformational human diseases, with special emphasis on the macromolecular homo- and heteroassociations of the malfolded proteins into characteristic ultrastructures found primarily in Parkinson's and Alzheimer's diseases.

Nervous system -- Degeneration -- Pathophysiology. --- Protein folding. --- Proteins -- Denaturation. --- Protein Folding --- Proteostasis Deficiencies --- Neurodegenerative Diseases --- Metabolic Diseases --- Biophysical Processes --- Biochemical Processes --- Nervous System Diseases --- Diseases --- Chemical Processes --- Nutritional and Metabolic Diseases --- Physical Processes --- Biophysical Phenomena --- Biochemical Phenomena --- Physical Phenomena --- Chemical Phenomena --- Phenomena and Processes --- Neurology --- Animal Biochemistry --- Medicine --- Human Anatomy & Physiology --- Health & Biological Sciences --- Nervous system --- Degeneration --- Pathophysiology. --- Folding of proteins --- Proteins --- Folding --- Medicine. --- Molecular biology. --- Neurosciences. --- Medical biochemistry. --- Cell biology. --- Neurobiology. --- Biomedicine. --- Biomedicine general. --- Molecular Medicine. --- Cell Biology. --- Medical Biochemistry. --- Organs (Anatomy) --- Neurosciences --- Conformation --- Cytology. --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Neural sciences --- Neurological sciences --- Neuroscience --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Composition --- Health Workforce --- Biomedicine, general. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Molecular biochemistry --- Molecular biophysics --- Biophysics --- Biomolecules --- Systems biology

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This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.

Proteomics. --- Molecular biology --- Proteins --- Proteasome Endopeptidase Complex. --- Proteostasis. --- Ubiquitin-Protein Ligases. --- E3 Ligase --- E3 Ubiquitin Ligase --- Ubiquitin Ligase E3 --- Ubiquitin-Protein Ligase E3 --- Ubiquitin-Protein Ligase --- Ligase E3, Ubiquitin --- Ligase E3, Ubiquitin-Protein --- Ligase, E3 --- Ligase, E3 Ubiquitin --- Ligase, Ubiquitin-Protein --- Ligases, Ubiquitin-Protein --- Ubiquitin Ligase, E3 --- Ubiquitin Protein Ligase --- Ubiquitin Protein Ligase E3 --- Ubiquitin Protein Ligases --- Protein Homeostasis --- Homeostases, Protein --- Homeostasis, Protein --- Protein Homeostases --- Proteostases --- Protein Folding --- Proteostasis Deficiencies --- 20S Proteasome --- Ingensin --- Macropain --- Macroxyproteinase --- Multicatalytic Endopeptidase Complex --- Multicatalytic Proteinase --- Prosome --- Proteasome --- Complex, Multicatalytic Endopeptidase --- Complex, Proteasome Endopeptidase --- Endopeptidase Complex, Multicatalytic --- Endopeptidase Complex, Proteasome --- Proteasome, 20S --- Proteinase, Multicatalytic --- Cell biology. --- Neurosciences. --- Immunology. --- Medicine. --- Cancer research. --- Cell Biology. --- Biomedicine, general. --- Cancer Research. --- Cancer research --- Health Workforce --- Immunobiology --- Life sciences --- Serology --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Cell biology --- Cellular biology --- Biology --- Cells --- Homeòstasi --- Proteïnes --- Immunologia --- Malalties --- Malaltia --- Medicina --- Discapacitat física --- Malalties cardiovasculars --- Malalties constitucionals --- Malalties de l'aparell digestiu --- Malalties de l'aparell genital --- Malalties de l'aparell respiratori --- Malalties de la pell --- Malalties del sistema nerviós --- Malalties dels animals --- Malalties hematològiques --- Malalties hereditàries --- Malalties de l'aparell locomotor --- Malalties d'origen nutricional --- Malalties iatrogèniques --- Malalties immunitàries --- Malalties otorrinolaringològiques --- Malalties rares --- Oftalmopaties --- Serveis d'urgències mèdiques --- Síndromes --- Trastorns de la nutrició --- Trastorns del metabolisme --- Epidemiologia --- Biologia --- Complements (Immunitat) --- Immunofarmacologia --- Immunologia clínica --- Immunologia de la trasplantació --- Neuroimmunologia --- Resposta immunitària --- Sistema immunitari --- Biomolècules --- Albúmines --- Apoproteïnes --- Conformació de proteïnes --- Enzims --- Factors de transcripció --- Glicoproteïnes --- Lipoproteïnes --- Nucleoproteïnes --- Pèptids --- Prions --- Protamines --- Proteïnes citosquelètiques --- Proteïnes de membrana --- Proteïnes de la sang --- Proteïnes recombinants --- Proteïnes supressores de tumors --- Receptors cel·lulars --- Ubiqüitina --- Xaperones moleculars --- Proteòmica --- Autorregulació (Fisiologia) --- Humors corporals --- Sistemes de control biològic --- Equilibri àcid-base --- Osmoregulació --- Cytology. --- Medicine—Research. --- Biology—Research. --- Cancer. --- Neuroscience. --- Biomedical Research. --- Cancer Biology. --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors