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This MIE volume provides laboratory techniques that aim to predict the structure of a protein which can have tremendous implications ranging from drug design, to cellular pathways and their dynamics, to viral entry into cells.Expert researchers introduce the most advanced technologies and techniques in protein structure and foldingIncludes techniques on tiling assays.

Proteins -- Analysis. --- Proteins -- Conformation. --- Proteins -- Structure. --- RNA. --- Proteins --- Conformation. --- Analysis. --- Ribonucleic acid --- Ribose nucleic acid --- Protein conformation --- Nucleic acids --- Ribose

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With the applications of prediction gaining momentum in fields such as enzymology and immunology, this volume presents an evaluation of present methods of expounding the various algorithms. These, when utilized on PCs or larger computers, can instantaneously take a primary amino acid sequence and produce a two- or three-dimensional image of the str.

Proteins --- Protein Conformation --- MODELS, MOLECULAR --- Conformation --- ultrastructure --- Conformation. --- Structure --- Mathematical models. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Protein conformation --- Structure&delete& --- Mathematical models --- Proteins - Structure - Mathematical models. --- Proteins - Conformation. --- Models, Molecular --- Conformation, Protein --- Conformations, Protein --- Protein Conformations --- Protein Folding --- Molecular Models --- Model, Molecular --- Molecular Model --- Molecular Conformation --- Molecular Structure --- Proteins - Conformation --- Proteins - ultrastructure --- PROTEINS --- PROTEIN CONFORMATION --- PROPERTIES

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This MIE volume provides laboratory techniques that aim to predict the structure of a protein which can have tremendous implications ranging from drug design, to cellular pathways and their dynamics, to viral entry into cells.Expert researchers introduce the most advanced technologies and techniques in protein structure and foldingIncludes techniques on tiling assays.

Proteins -- Analysis. --- Proteins -- Conformation. --- RNA. --- Molecular Conformation --- Amino Acids, Peptides, and Proteins --- Nucleic Acid Probes --- Nucleic Acids --- RNA Probes --- Proteins --- RNA --- Protein Conformation --- Nucleic Acids, Nucleotides, and Nucleosides --- Chemicals and Drugs --- Molecular Probes --- Molecular Structure --- Laboratory Chemicals --- Biochemical Phenomena --- Chemical Phenomena --- Specialty Uses of Chemicals --- Phenomena and Processes --- Chemical Actions and Uses --- Human Anatomy & Physiology --- Animal Biochemistry --- Health & Biological Sciences --- Analysis. --- Ribonucleic acid --- Ribose nucleic acid --- Nucleic acids --- Ribose

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The economic burden of dementia was estimated as being US$ 604 billion in 2010. Now it is time for new guidelines in handling of neurodegenerative disorders. Optimistic versus Pessimistic Prognosis depends much on diagnostic and treatment approaches which healthcare will preferably adopt in the near future. Current dramatic situation can be significantly improved by the implementation of appropriate early diagnostic, targeted preventive measures and therapies tailored to the person advancing healthcare and enhancing the patient life quality. Neurodegenerative Diseases are pathologies of multi-factorial nature involving interplay of epi/genetic and environmental risk factors. Insights into molecular pathomechanisms will enable to create the most effective neuro-protective strategies and individualised treatment before manifest pathology. Utilization of the advanced integrative medical approach could enable a significant portion of population to reach the 100-year age limit remaining vibrant in excellent physical and mental health as actively contributing members of the society. The crucial role of the integrative approach by PPPM has been acknowledged as priorities by World Health Organization, United Nations and the European Union among others. Extensive efforts of international consortia are essential in the field to consolidate the accumulated expertise and to create population screening, robust diagnostic approaches, effective prevention in groups at high risk and targeted treatments. This book volume "Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future" is intended to serve as a reference source for basic researchers and healthcare industry involved in the field of neurosciences with a special emphasis on mental health promotion and innovations intended to delay or even prevent neurodegenerative diseases.

Nervous system -- Degeneration -- Etiology. --- Proteins -- Conformation. --- Nervous system --- Therapeutics --- Investigative Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Nervous System Diseases --- Public Health --- Diseases --- Medicine --- Health Occupations --- Disciplines and Occupations --- Individualized Medicine --- Neurodegenerative Diseases --- Methods --- Preventive Medicine --- Diagnosis --- Degeneration --- Therapeutics. --- Degeneration. --- Medical treatment --- Therapy --- Treatment of diseases --- Treatments for diseases --- Degeneration, Nerve --- Nerve degeneration --- Nervous system degeneration --- Neurodegenerative disease --- Neurodegenerative diseases --- Neurodegenerative disorders --- Neuron degeneration --- Nissl degeneration --- Retrograde degeneration --- Wallerian degeneration --- Degeneration and regeneration --- Medicine. --- Neurosciences. --- Health promotion. --- Neurology. --- Biomedicine. --- Biomedicine general. --- Health Promotion and Disease Prevention. --- Clinical medicine --- Degeneration (Pathology) --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Neuropsychiatry --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Health Workforce --- Neurology . --- Biomedicine, general. --- Health promotion programs --- Health promotion services --- Promotion of health --- Wellness programs --- Preventive health services --- Health education --- Biology --- Medicine, Preventive. --- Biomedical Research. --- Neuroscience. --- Research. --- Disease prevention --- Prevention of disease --- Preventive medicine --- Preventive medicine physicians --- Public health --- Biological research --- Biomedical research --- Prevention

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Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions.

Fuzzy systems. --- Protein binding. --- Protein Conformation. --- Protein folding. --- Proteins -- Conformation. --- Proteins --- Protein folding --- Protein binding --- Fuzzy systems --- Protein Unfolding --- Molecular Conformation --- Investigative Techniques --- Protein Folding --- Molecular Structure --- Biophysical Processes --- Biochemical Phenomena --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Biochemical Processes --- Chemical Processes --- Chemical Phenomena --- Biophysical Phenomena --- Physical Processes --- Phenomena and Processes --- Physical Phenomena --- Protein Denaturation --- Protein Conformation --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Conformation --- Conformation. --- Systems, Fuzzy --- Binding, Protein --- Folding of proteins --- Protein conformation --- Folding --- Medicine. --- Molecular biology. --- Biomedicine. --- Biomedicine general. --- Molecular Medicine. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- System analysis --- Fuzzy logic --- Allosteric proteins --- Radioligand assay --- Health Workforce --- Biomedicine, general.