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Protein Conformation. --- Proteins --- Structure-Activity Relationship. --- Conformation, Protein --- Conformations, Protein --- Protein Conformations --- Protein Folding --- analysis. --- physiology. --- Relationship, Structure-Activity --- Relationships, Structure-Activity --- Structure Activity Relationship --- Structure-Activity Relationships --- Analysis --- Structure --- Biochemistry --- Technique --- Structure-activity relationships (Biochemistry). --- Structure. --- Conformation. --- Analysis. --- Physiology.

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Proteins --- Enzymes --- Protein Conformation. --- Proteins. --- Enzymes. --- Protéines --- Périodiques. --- Biocatalysts --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Conformation, Protein --- Conformations, Protein --- Protein Conformations --- Ferments --- Soluble ferments --- Molecular Mechanisms of Pharmacological Action --- Protein Folding --- Catalysts --- Enzymology --- Biocatalyst --- Enzyme --- Protein

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"Intrinsically Disordered Proteins: Dynamics, Binding, and Function thoroughly examines and ties together the fundamental biochemical functions of intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs), including signaling, binding, and regulation, with the methodology for study and the associated pathways for drug design and therapeutic intervention. The role of new mechanistic, computational, and experimental approaches in IDP study are explored in depth, with methods for the characterization of IDP dynamics; models, simulations, and mechanisms of IDP and IDR binding; and biological and medical implications of IDP dynamics prominently featured. Written and edited by leading scientists in the field, this book explores groundbreaking areas such as ensemble descriptions of IDPs and IDRs, single-molecule studies of IDPs and IDRs, IDPs and IDRs in membraneless organelles, and molecular mechanisms of fibrillation of IDPs. Intrinsically Disordered Proteins provides students and researchers in biochemistry, molecular biology, and applied microbiology with a comprehensive and updated discussion of the complex dynamics of IDPs and IDRs."--

Proteins --- Structure. --- Intrinsically Disordered Proteins --- Carrier Proteins. --- Protein Conformation --- physiology. --- Conformation, Protein --- Conformations, Protein --- Protein Conformations --- Protein Folding --- Binding Protein --- Binding Proteins --- Transport Proteins --- Protein, Binding --- Proteins, Binding --- Proteins, Carrier --- Proteins, Transport --- Protein Binding --- Receptors, Transferrin --- Carrier Protein --- Transport Protein --- Protein, Carrier --- Protein, Transport

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"The book aims to provide the reader with a detailed description of protein structure and dynamics, combined with an in-depth discussion of the relationship between both these aspects and protein function. Adopting the structural-biophysical approach, we discuss these in relation to molecular interactions and thermodynamic changes that transpire in this highly complex system. There are several types of textbooks describing protein structure and function. Biochemistry textbooks emphasize the functional aspect of proteins and provide a rather general description of structure and structure-function relationship (SFR). Structural Biology textbooks provide an extensive description of protein structure and also refer to SFR with varying degrees of detail. However, energy-related aspects are often avoided. Molecular biophysics textbooks focus on molecular interactions and thermodynamic aspects of protein structure, but tend to lack detailed description of structural and dynamic aspects, as well as SFR. Our book refers to all of the aforementioned aspects and attempts to provide a unified view. Our energy-oriented approach is manifested throughout the book, whether we discuss structure, dynamics or specific functions of proteins. An extensive discussion of the energetics of protein structure is also given in a chapter dedicated to this topic."--

Proteins --- Physical biochemistry --- Amino Acid Sequence --- Protein Conformation --- Structure-activity relationships --- physiology --- 577.122 --- 577.122 Protein metabolism --- Protein metabolism --- Amino Acid Sequences --- Sequence, Amino Acid --- Sequences, Amino Acid --- Protein Structure, Primary --- Primary Protein Structure --- Primary Protein Structures --- Protein Structures, Primary --- Structure, Primary Protein --- Structures, Primary Protein --- Peptides --- Conformation, Protein --- Conformations, Protein --- Protein Conformations --- Protein Folding --- Biophysical chemistry --- Biochemistry --- Physical organic chemistry --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Proteins - Structure-activity relationships --- Proteins - physiology

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The prediction of the three-dimensional structure of a protein from its amino acid sequence is a problem faced by an increasing number of biological scientists. This book provides a practical guide to making these predictions by reviewing strategies of different computer modeling algorithms and highlighting the degree of confidence attributed to them. Also in the volume are descriptions of the following: the principles of protein folding; sequence homology and motif searches; prediction of secondary structure; homology modeling; modeling of antibody combining sites; tertiary fold recognition; modeling of transmembrane proteins; ab initio prediction; protein-ligand docking simulations; and the use of molecular mechanics and dynamics. both non-specialists who require guidance to identify and evaluate appropriate strategies and experts who require a contemporary view of the field, will find this volume a worthy addition to their research libraries.

Human biochemistry --- Proteins --- Conformation --- Computer simulation. --- Protein Conformation --- Computer Simulation --- Computerized Models --- In Silico --- Computer Models --- Models, Computer --- Computer Model --- Computer Simulations --- Computerized Model --- In Silicos --- Model, Computer --- Model, Computerized --- Models, Computerized --- Silico, In --- Silicos, In --- Simulation, Computer --- Simulations, Computer --- Conformation, Protein --- Conformations, Protein --- Protein Conformations --- Protein Folding --- Gene Products, Protein --- Gene Proteins --- Protein --- Protein Gene Products --- Proteins, Gene --- Molecular Mechanisms of Pharmacological Action --- Conformation&delete& --- Computer simulation --- PROTEINS --- LIGANDS --- MODELLING --- ANTIBODIES --- MEMBRANES --- MOLECULAR BIOLOGY --- STRUCTURAL ANALYSIS --- eiwitten --- aminozuursequenties --- amino acid sequences --- nucleotidenvolgordes --- nucleotide sequences --- databanken --- databases --- analytische methoden --- analytical methods --- Proteins and Enzymes --- Eiwitten en enzymen --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Proteins - Conformation - Computer simulation.