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Using genome sequencing, one can predict possible interactions among proteins. There are very few titles that focus on protein-protein interaction predictions in bacteria. The authors will describe these methods and further highlight its use to predict various biological pathways and complexity of the cellular response to various environmental conditions. Topics include analysis of complex genome-scale protein-protein interaction networks, effects of reference genome selection on prediction accuracy, and genome sequence templates to predict protein function.
Functional genomics. --- Protein-protein interactions. --- Interactions, Protein-protein --- Protein interactions --- Physiological genomics --- Protein-protein interactions --- Bacterial genetics --- Protein Interaction Mapping --- Protein Array Analysis --- Life sciences. --- Human genetics. --- Proteomics. --- Bioinformatics. --- Systems biology. --- Life Sciences. --- Systems Biology. --- Human Genetics. --- Molecular association --- Genomics --- Physiology --- Biological models. --- Molecular biology --- Proteins --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Systems biology --- Models, Biological --- Data processing --- Bioinformatics --- Biological systems
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M. B. Nodwell S. A. Sieber ABPP Methodology: Introduction and Overview J. Krysiak R. Breinbauer Activity-Based Protein Profiling for Natural Product Target Discovery P. P. Geurink L. M. Prely G. A. van der Marel R. Bischoff H. S. Overkleeft Photoaffinity Labeling in Activity-Based Protein Profiling W. P. Heal E. W. Tate Application of Activity-Based Protein Profiling to the Study of Microbial Pathogenesis Y.-G. Kim A. Saghatelian Functional Analysis of Protein Targets by Metabolomic Approaches. .
Proteomics --- Proteins --- Molecular Probe Techniques --- Biochemistry --- Genomics --- Microarray Analysis --- Biological Science Disciplines --- Microchip Analytical Procedures --- Amino Acids, Peptides, and Proteins --- Genetic Techniques --- Computational Biology --- Chemistry --- Investigative Techniques --- Genetics --- Biology --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemicals and Drugs --- Chemistry Techniques, Analytical --- Natural Science Disciplines --- Disciplines and Occupations --- Protein Array Analysis --- Proteome --- Human Anatomy & Physiology --- Physical Sciences & Mathematics --- Health & Biological Sciences --- Animal Biochemistry --- Chemistry - General --- Proteomics. --- Proteins. --- Proteids --- Chemistry. --- Pharmaceutical technology. --- Organic chemistry. --- Organic Chemistry. --- Pharmaceutical Sciences/Technology. --- Molecular biology --- Biomolecules --- Polypeptides --- Chemistry, Organic. --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Organic chemistry --- Pharmaceutical technology --- Chemistry, Organic
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Microarray technology has made strong progress over the past decade, and there have also been significant changes in application areas, from nucleic acids to proteomics and from research to clinical applications. This book provides a comprehensive overview of microarrays in diagnostics and biomarker development, covering DNA, peptide, protein and tissue arrays. The focus is on entities that are in actual clinical use, or quite close, and on recent developments, such as peptide and aptamer arrays. A further topic is the miniaturisation towards “nanoarrays”, which is expected to have great potential in clinical applications. Relevant issues of bioinformatics and statistical analysis of array data are discussed in detail, as well as the barriers to the commercialisation of array-based tests and the vexing IP issues involved. Thus, the book should be very useful tor active array users as well as to newcomers seeking to make the best choice between different technologies.
Cytology. --- DNA microarrays. --- Medicine. --- Protein microarrays. --- DNA microarrays --- Protein microarrays --- Sequence Analysis --- Molecular Probe Techniques --- Investigative Techniques --- Microarray Analysis --- Nucleic Acid Hybridization --- Genetic Techniques --- Microchip Analytical Procedures --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemistry Techniques, Analytical --- Protein Array Analysis --- Oligonucleotide Array Sequence Analysis --- Clinical Laboratory Techniques --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Biomedical Engineering --- Biochemical markers. --- Biologic markers --- Biological markers --- Biomarkers --- Markers, Biochemical --- DNA biochips --- Microarrays, DNA --- Microarrays. --- Cell biology. --- Biomedicine. --- Cell Biology. --- Biochemistry --- Indicators (Biology) --- Biochips --- Immobilized nucleic acids --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists
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This detailed book presents a technical overview and practical methodology of a variety of antibody array formats and technologies. As advantages and disadvantages of antibody array types are explored, the volume also delves into practical applications of antibody arrays pertaining to investigations of specific research topics and biological processes as well as guidance on the methods of processing, analysis, and storage of array data. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Antibody Arrays: Methods and Protocols aims to empower the reader with the information required to select the most appropriate array for their research application, with the technical knowledge to use and process the array, and with the knowledge to perform analysis that realizes the maximum benefit from the data generated.
Immunoglobulins. --- Protein microarrays. --- Antibodies. --- Protein Array Analysis. --- Microarray Analysis. --- Microarrays, Protein --- Peptide biochips --- Peptide microarrays --- Protein biochips --- Biochips --- Immobilized proteins --- Antibodies --- Immune globulins --- Immune serum globulin --- Blood proteins --- Globulins --- Plasma cells --- Antibody diversity --- Antigens --- Bacterial immunoglobulin-binding proteins --- Microarray Analytical Devices --- Microarray Microchips --- Nanoarray Analytical Devices --- Analysis, Microarray --- Analytical Device, Microarray --- Analytical Device, Nanoarray --- Analytical Devices, Microarray --- Analytical Devices, Nanoarray --- Device, Microarray Analytical --- Device, Nanoarray Analytical --- Devices, Microarray Analytical --- Devices, Nanoarray Analytical --- Microarray Analytical Device --- Microarray Microchip --- Microchip, Microarray --- Microchips, Microarray --- Nanoarray Analytical Device --- Protein Array Assay --- Protein Arrays --- Protein Biochips --- Protein Microarray Analysis --- Protein Microarray Assay --- Protein Profiling Microarrays --- ProteinChip --- Protein Chips --- Protein Microarrays --- Protein Microchips --- Protein Profiling Chips --- Analyses, Protein Array --- Analyses, Protein Microarray --- Analysis, Protein Array --- Analysis, Protein Microarray --- Array Analyses, Protein --- Array Analysis, Protein --- Array Assay, Protein --- Array Assays, Protein --- Array, Protein --- Arrays, Protein --- Assay, Protein Array --- Assay, Protein Microarray --- Assays, Protein Array --- Assays, Protein Microarray --- Biochip, Protein --- Biochips, Protein --- Chip, Protein --- Chip, Protein Profiling --- Chips, Protein --- Chips, Protein Profiling --- Microarray Analyses, Protein --- Microarray Analysis, Protein --- Microarray Assay, Protein --- Microarray Assays, Protein --- Microarray, Protein --- Microarray, Protein Profiling --- Microarrays, Protein Profiling --- Microchip, Protein --- Microchips, Protein --- Profiling Chip, Protein --- Profiling Chips, Protein --- Profiling Microarray, Protein --- Profiling Microarrays, Protein --- Protein Array --- Protein Array Analyses --- Protein Array Assays --- Protein Biochip --- Protein Chip --- Protein Microarray --- Protein Microarray Analyses --- Protein Microarray Assays --- Protein Microchip --- Protein Profiling Chip --- Protein Profiling Microarray --- ProteinChips --- Protein Interaction Mapping --- Biology—Technique. --- Chemistry. --- Biological Techniques. --- Physical sciences
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