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Propolis --- Bee glue --- Bee products --- Therapeutic use.

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Natural compounds, from terrestrial and marine sources, are the result of an evolutionary process which originated in compounds with great structural diversity, multiple biological activities and miscellaneous applications. A large and very active research field is dedicated to identifying biosynthesized compounds; to improve/develop new methodologies to produce/reuse natural compounds; to assess their potential; and to understand their mechanism of action. This Special Issue brings together excellent original and review works, focused on the most recent advances related to the secondary metabolites’ composition of natural sources, and the proposal of new applications for their constituents, such as therapeutic agents, and pesticides or food ingredients.

Research & information: general --- Biology, life sciences --- heterologous expression --- Streptomyces --- secondary metabolite --- Garcinia xanthochymus --- growth inhibitory compounds --- allelopathy --- vanillic acid --- methyl phloretate --- allelopathic activity --- growth inhibitor --- phenolic compounds --- bioherbicide --- sustainable agriculture --- pulsed electric fields --- green extraction --- microalgae --- antioxidants --- pigments --- thymoquinone --- UHRF1 --- ubiquitination --- HAUSP --- tumor suppressor genes --- aaptoline B --- pyrroloquinoline --- Ag(I)-catalyzed cycloisomerization --- dopaminergic neuroprotection --- Parkinson's disease --- bioactive compounds --- cardiovascular --- nanodelivery --- bioavailability --- Ailanthus altissima --- biological properties --- analytical techniques --- potential applications --- propolis contamination --- propolis cytotoxicity --- antimicrobial activity --- antiprotozoal activity --- artepelin C --- formononetin --- pinocembrin --- quercetin --- kaempferol --- propolis extract --- Asparagopsis armata --- Rhodophyta --- GC-MS --- UHPLC-MS --- dibrominated compounds --- 1,4-dibromobuten-1-ol --- palmitic acid --- brominated phenolics --- red seaweed --- invasive seaweed --- invasive species --- flowers --- antioxidant --- microbial activity --- bioactivity --- enzyme inhibitory potential --- acetylcholinesterase --- lipase --- α-glucosidase --- heterologous expression --- Streptomyces --- secondary metabolite --- Garcinia xanthochymus --- growth inhibitory compounds --- allelopathy --- vanillic acid --- methyl phloretate --- allelopathic activity --- growth inhibitor --- phenolic compounds --- bioherbicide --- sustainable agriculture --- pulsed electric fields --- green extraction --- microalgae --- antioxidants --- pigments --- thymoquinone --- UHRF1 --- ubiquitination --- HAUSP --- tumor suppressor genes --- aaptoline B --- pyrroloquinoline --- Ag(I)-catalyzed cycloisomerization --- dopaminergic neuroprotection --- Parkinson's disease --- bioactive compounds --- cardiovascular --- nanodelivery --- bioavailability --- Ailanthus altissima --- biological properties --- analytical techniques --- potential applications --- propolis contamination --- propolis cytotoxicity --- antimicrobial activity --- antiprotozoal activity --- artepelin C --- formononetin --- pinocembrin --- quercetin --- kaempferol --- propolis extract --- Asparagopsis armata --- Rhodophyta --- GC-MS --- UHPLC-MS --- dibrominated compounds --- 1,4-dibromobuten-1-ol --- palmitic acid --- brominated phenolics --- red seaweed --- invasive seaweed --- invasive species --- flowers --- antioxidant --- microbial activity --- bioactivity --- enzyme inhibitory potential --- acetylcholinesterase --- lipase --- α-glucosidase

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The papers collected in this Special Issue entitled “Electrospun Nanomaterials: Applications in Food, Environmental Remediation, and Bioengineering” illustrate the high diversity and potential for implementation of electrospun nanofibers in these fields, including the covering of a wide number of subtopics. Examples of these applications have included bioactive scaffolds, wound healing dressings, compound protective nanoreservoirs and sustained and controlled release systems. An important driver of these applications results from advances in materials science and new nanofiber manufacturing processes. Definitely, such pieces of fundamental research will contribute to the promotion of electrospinning as a focal point in the future development of technological applications at the interface of biological systems, which promise long-term benefits for both health and the environment.

Technology: general issues --- electrospinning --- curcumin --- PLA/PEG/curcumin nanofiber --- drug release --- porous nanofiber --- polycaprolactone --- nanofibers --- COOH plasma --- cell adhesion and spreading --- cell viability --- freeze–thawed platelet-rich plasma immobilization --- piezoelectricity --- scaffold --- polyvinylidene fluoride --- polyvinylidene fluoride-trifluoroethylene --- tissue engineering --- osteoblast --- neuron --- stem cell --- aligned fiber --- HDPAF --- micro-nanofibers --- β-carotene --- thermoprotection --- photoprotection --- antibacterial effect --- centella --- propolis --- hinokitiol --- biodegradable polymer --- PHBH --- nanofiber --- food packaging --- functional membrane --- biomaterials --- polymers --- PMVE/MA --- nanoparticles --- nanoencapsulation --- antibiotics --- electrospun nanofibers --- polyethylene oxide nanofibers PEO-NFs --- microbial fuel cells --- honey --- food industry --- recovered energy (Erec) --- chitosan --- chitin nanofibrils --- hemostatic material --- hemorrhage --- photoactive nanoparticles --- cadmium selenide --- cellulose acetate --- electrospun fibers --- solar thermal --- n/a --- freeze-thawed platelet-rich plasma immobilization

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The papers collected in this Special Issue entitled “Electrospun Nanomaterials: Applications in Food, Environmental Remediation, and Bioengineering” illustrate the high diversity and potential for implementation of electrospun nanofibers in these fields, including the covering of a wide number of subtopics. Examples of these applications have included bioactive scaffolds, wound healing dressings, compound protective nanoreservoirs and sustained and controlled release systems. An important driver of these applications results from advances in materials science and new nanofiber manufacturing processes. Definitely, such pieces of fundamental research will contribute to the promotion of electrospinning as a focal point in the future development of technological applications at the interface of biological systems, which promise long-term benefits for both health and the environment.

Technology: general issues --- electrospinning --- curcumin --- PLA/PEG/curcumin nanofiber --- drug release --- porous nanofiber --- polycaprolactone --- nanofibers --- COOH plasma --- cell adhesion and spreading --- cell viability --- freeze-thawed platelet-rich plasma immobilization --- piezoelectricity --- scaffold --- polyvinylidene fluoride --- polyvinylidene fluoride-trifluoroethylene --- tissue engineering --- osteoblast --- neuron --- stem cell --- aligned fiber --- HDPAF --- micro-nanofibers --- β-carotene --- thermoprotection --- photoprotection --- antibacterial effect --- centella --- propolis --- hinokitiol --- biodegradable polymer --- PHBH --- nanofiber --- food packaging --- functional membrane --- biomaterials --- polymers --- PMVE/MA --- nanoparticles --- nanoencapsulation --- antibiotics --- electrospun nanofibers --- polyethylene oxide nanofibers PEO-NFs --- microbial fuel cells --- honey --- food industry --- recovered energy (Erec) --- chitosan --- chitin nanofibrils --- hemostatic material --- hemorrhage --- photoactive nanoparticles --- cadmium selenide --- cellulose acetate --- electrospun fibers --- solar thermal --- electrospinning --- curcumin --- PLA/PEG/curcumin nanofiber --- drug release --- porous nanofiber --- polycaprolactone --- nanofibers --- COOH plasma --- cell adhesion and spreading --- cell viability --- freeze-thawed platelet-rich plasma immobilization --- piezoelectricity --- scaffold --- polyvinylidene fluoride --- polyvinylidene fluoride-trifluoroethylene --- tissue engineering --- osteoblast --- neuron --- stem cell --- aligned fiber --- HDPAF --- micro-nanofibers --- β-carotene --- thermoprotection --- photoprotection --- antibacterial effect --- centella --- propolis --- hinokitiol --- biodegradable polymer --- PHBH --- nanofiber --- food packaging --- functional membrane --- biomaterials --- polymers --- PMVE/MA --- nanoparticles --- nanoencapsulation --- antibiotics --- electrospun nanofibers --- polyethylene oxide nanofibers PEO-NFs --- microbial fuel cells --- honey --- food industry --- recovered energy (Erec) --- chitosan --- chitin nanofibrils --- hemostatic material --- hemorrhage --- photoactive nanoparticles --- cadmium selenide --- cellulose acetate --- electrospun fibers --- solar thermal

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Nature represents an amazing source of inspiration, since it produces a great diversity of natural compounds selected by evolution, which exhibit multiple biological activities and applications. A large and very active research field is dedicated to identifying biosynthesized compounds, to improve/develop new methodologies, to produce/reuse natural compounds, and to assess their potential for pharmaceutical, cosmetic and food industries, among others, and additionally, to understand their mechanism of action. This book is dedicated to presenting the most recent results on the development of natural compounds’ applications. Ten original research works, organized by applications, and two reviews are included. Each of them contributes to the knowledge advance, insofar as they present new applications for known products, new methodologies to obtain new products, or the evaluation of a given application, with the applications related to health promotion being the most frequently considered. These works are significant contributions and reinforce the dynamic field of natural products’ applications.

Medicine --- amino acid metabolism --- carvacrol --- metabolomics data --- oxidative stress --- Penicillium digitatum --- Prangos pabularia Lindl. --- volatile oil --- PTP-1B --- osthole --- 5-pentylcyclohexa-1,3-diene --- antidiabetic activity --- chalcones --- aldol condensation --- biological activity --- flavanones --- cytotoxic --- antioxidant --- anticholinesterase --- Maytenus --- celastroloids --- semisynthesis --- antibacterial activity --- structure–activity relationship --- rosemary --- rosmarinic acid --- anticancer --- antidiabetic --- cardioprotective --- Helianthus annuus --- Helianthus strumosus --- Aspergillus niger --- Candida albicans --- Cryptococcus neoformans --- α-pinene --- oleracone --- flavonoid --- anti-aging --- longevity --- Portulaca oleracea L. --- Caenorhabditis elegans --- total synthesis --- pimenta d’água --- Candida --- fungistatic effect --- inhibition of dimorphism --- GC/MS --- colorectal cancer --- Salviae miltiorrhizae radix --- apoptosis --- honey --- propolis --- phenolic compounds --- wound-healing activity --- NHDF cells --- Asteraceae --- sesquiterpene lactones --- alantolactone --- arglabin --- parthenolide --- thapsigargin --- in vivo study --- anti-inflammatory --- almond --- byproducts --- chlorogenic acid --- design of experiment --- phenolic acids --- ultrasound-assisted extraction --- natural compounds --- therapeutic applications --- essential oils --- antimicrobial --- antitumor --- SAR