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Book
ISBN: 3540601139 3642799124 3642799108 Year: 1996 Volume: 208 Publisher: Berlin : Springer,
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Cell proliferation --- Cell regulation --- Cell renewal --- Cellen--Proliferatie --- Cellular control mechanisms --- Cellular proliferation --- Celregulatie --- Proliferation cellulaire --- Régulation cellulaire --- Adenovirus E2 Proteins --- Growth Inhibitors --- Transcription, Genetic. --- Genetics --- Genetics. --- Genetic transcription --- Regulation --- Cells --- Growth
Book
ISBN: 3540634290 3642719430 3642719414 9783540634294 Year: 1998 Volume: 227 Publisher: Berlin ; Milan ; Paris Springer
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More than 10 years ago, the discovery of cyclin-dependent ki nases (Cdks) ushered in a new era in the understanding of cell proliferation and its control. Not only were both of the known cell cycle transitions, from G 1 to S phase and G2 to M phase, found to be dependent on these protein kinases, but the reg ulatory assumption intrinsic to cyclin-dependent kinases, a stable inactive catalytic subunit (the Cdk) and an unstable requisite positive regulatory activating subunit (the cyclin), led to a simple model for cell cycle control. Modulation of cyclin accumulation, and thereby Cdk activation, was proposed to be the overarching principle governing the passage through cell cycle phases. An other reality to emerge from the discovery of Cdks was the ex ceptional degree of evolutionary conservation maintained in the machinery and organization of proliferation control. Not only were Cdks shown to be structurally conserved between yeast and man, but mammalian Cdks could substitute functionally for the endogenous enzymes in a yeast cell. The problem of cell cycle control was thought to have been virtually solved. The ensuing years have provided a much more complex view of cell cycle control and the role and regulation of Cdks. The uncritical enthusiasm with which many of the ideas were em braced has required tempering. For example, although Cdks appear to be highly conserved phylogenetically, cyclins are much less so.
Cancer--Pathogenesis --- Carcinogenese --- Carcinogenesis --- Carcinogénèse --- Cell proliferation --- Cell renewal --- Cellen--Proliferatie --- Cellular proliferation --- Kanker--Ontstaan --- Oncogenesis --- Pathogenesis of cancer --- Proliferation cellulaire --- Tumorigenesis --- Cyclin kinase --- Inhibitors --- Immunology. --- Cell biology. --- Cancer research. --- Biochemistry. --- Cell Biology. --- Cancer Research. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Cancer research --- Cell biology --- Cellular biology --- Cells --- Immunobiology --- Life sciences --- Serology --- Composition
Periodical
ISSN: 09607722 13652184 Publisher: Oxford
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Histology. Cytology --- Genetics --- Cell proliferation --- Cells --- Molecular biology --- Tissue metabolism --- Cell Cycle --- Cell Differentiation --- Cellules --- Biologie moléculaire --- Tissus (Histologie) --- Periodicals --- periodicals --- Prolifération --- Périodiques --- Métabolisme --- Cell cycle --- Cell Cycle. --- Cell Differentiation. --- Societies, Medical. --- Cell cycle. --- Cell proliferation. --- Prolifération cellulaire. --- Différenciation cellulaire. --- Cycle cellulaire. --- Cell Division. --- Histology. --- Cell Biology. --- Cellular Biology --- Cytology --- Biologies, Cell --- Biologies, Cellular --- Biology, Cell --- Biology, Cellular --- Cell Biologies --- Cellular Biologies --- Cell Division Phase --- Cell Divisions --- M Phase --- Division Phase, Cell --- Division, Cell --- Divisions, Cell --- M Phases --- Phase, Cell Division --- Phase, M --- Phases, M --- Cleavage Stage, Ovum --- Information Technology --- Life Sciences --- Modelling & Simulation --- Biology --- Cytology, Cell Biology --- Micro and Molecular Biology --- Biologie moléculaire --- Prolifération --- Périodiques --- Métabolisme --- EBSCOASP-E EJBIOLO EJBIOMO EJMEDEC EPUB-ALPHA-C EPUB-PER-FT MDCYTOLO WILEY-E --- Cell Division --- Histology --- Cell Biology --- periodicals. --- MDCYTOLO --- stem cells --- regenerative medicine --- tissue engineering --- cell biology --- cell proliferation --- cancer --- Cell renewal --- Cellular proliferation --- Cell division --- Cell populations --- Mitotic cycle --- Nuclear cycle (Cytology) --- Biological rhythms --- Cell Division Cycle --- Cell Cycles --- Cell Division Cycles --- Cycle, Cell --- Cycle, Cell Division --- Cycles, Cell --- Cycles, Cell Division --- Division Cycle, Cell --- Division Cycles, Cell --- Cell Cycle Proteins --- Genes, cdc --- Medical Societies --- Medical Society --- Society, Medical --- Differentiation, Cell --- Cell Differentiations --- Differentiations, Cell --- Embryo, Mammalian --- Gene Expression Regulation --- Cell Lineage --- Growth --- Oncology. Neoplasms --- Periodicals. --- Cycle cellulaire --- Cytologie --- Celcyclus. --- Celdifferentiatie. --- Différenciation
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