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Les radiopharmaceutiques désignent des molécules radioactives capables de diagnostiquer ou de soigner une maladie et qui, à ce titre, sont considérées comme des médicaments. La recherche de nouveaux radiopharmaceutiques impose une collaboration entre des cliniciens qui définissent les besoins, des chimistes qui synthétisent les molécules, et enfin des biologistes, des radiopharmaciens et des médecins nucléaires qui étudient leur devenir biologique. Ce livre est le fruit d'une telle collaboration. Ayant pour ambition de faire le point sur les connaissances en chimie et en biologie des radiopharmaceutiques, le livre se veut accessible à un large public de chimistes et biologistes non spécialistes du domaine, c'est pourquoi une place importante est accordée aux rappels de notions de base.
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"This comprehensive overview details the process of radiopharmaceutical development, from cellular studies to animal experiments to the design and implementation of clinical trials. It examines the relative benefits of various radiopharmaceuticals and provides guidance on dose estimation and agent selection. Utilizing figures of merit for quantitative assessment, it covers standard medical internal radiation dose (MIRD), absorbed dose method for imaging agents, vivo methods for obtaining activity data, errors of activity estimation techniques, phantom-based and patient-based dose estimates and their associated uncertainties, and options available to clinical physicists. Supported by numerous examples from clinical trials, it discusses two and three dimensional estimation processes, including modern hybrid scanners such as SPECT /CT and PET/CT"--Provided by publisher.
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This is the classic text/reference of nuclear pharmacy, thoroughly updated and judiciously expanded. Generously supplemented with charts, tables, and more than 100 illustrations throughout, each chapter provides the reader with well-delineated descriptions, from the basic autotomic structure through the clinical uses of radiopharmaceuticals. Previous editions were unanimously priased for their clarity and accuracy, as Dr. Saha set new standards for making complex theoretical concepts readily understandable for students and practitioners in nuclear pharmacy and nuclear medicine. New features in the Fourth Edition include: - up-to-date descriptions of the latest NRC and FDA regulations - clinical uses of all new radiopharmaceuticals and techniques, including those radiopharmaceuticals having the potential for clinical use - quality control data for all new radiopharmaceuticals - dosimetry data for all new radiopharmaceuticals - an entire new chapter devoted to the therapeutic uses of radiopharmaceuticals - an upgraded section on 99mTc chemistry - addition to the 62Zn-62Cu generator in th chapter on "Radionuclide Generators" - latest developments in brain, heart, and tumor imaging - a new section on parathyroid imaging From reviuews of the Third Edition: "¿the strengths of this edition, coupled with its currentness, make this book today's frontrunner among introductory radiopharmacy texts." -Clinical Nuclear Medicine "¿an excellent overview of all different aspects of nuclear pharmacy¿consistent, well-written, concise¿. I can recommend it as a reference in nuclear pharmacy and as a textbook for nuclear medicine technologists." -European Journal of Nuclear Medicine
Radiopharmaceuticals. --- Nuclear medicine. --- WN 440 Nuclear medicine --- Radiopharmaceuticals --- Nuclear Medicine --- Produits radiopharmaceutiques --- Nuclear medicine --- Radiopharmaceutiques --- Médecine nucléaire --- Pharmacy. --- Medicine. --- Radiology. --- Radiotherapy. --- Medicine & Public Health. --- Nuclear Medicine. --- Imaging / Radiology. --- Médecine nucléaire --- Pharmacy --- EPUB-LIV-FT SPRINGER-B --- Radiology, Medical. --- Médecine nucléaire. --- Produits radiopharmaceutiques. --- Radiation therapy --- Electrotherapeutics --- Hospitals --- Medical electronics --- Medical radiology --- Therapeutics, Physiological --- Phototherapy --- Radiological physics --- Physics --- Radiation --- Chemistry --- Medicine --- Drugs --- Materia medica --- Pharmacology --- Atomic medicine --- Radioisotopes in medicine --- Radioactive tracers --- Radioactivity --- Radiological services --- Physiological effect --- Analysis.
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