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Worldwide, 278 million people are estimated to have moderate to profound hearing loss. Age-related hearing loss, also known as presbyacusis, affects approximately half of the population over 60 years old, making it the second most common cause of disability in older people. Hearing loss occurs when the sensory cells and neurons of the cochlea degenerate and die. The vestibular system, which holds the sense of balance, shares a common embryonic origin with the cochlea and together conform the inner ear. Balance problems are a trait of ageing to the point that balance ability is considered a sensor of physical decline and vestibular degeneration is the most common cause of falls in the elderly. Still the molecular bases of ageing in the vestibular system have not been studied in detail. Genetic and environmental factors contribute to the progression of age-related hearing loss (ARHL). Being noise the main environmental noxious agent for human hearing in the industrialized societies.There is no restorative treatment for deafness but functional replacement by means of prosthesis. Therefore, prevention and treatment of hearing loss is an unmet medical need. To develop innovative medical strategies against hearing loss, it is critical to understand the causes of ARHL and the essential pathways responsible for the manifestation of this complex disease.In this research topic, experts will discuss the stages and molecular elements of the damage and repair processes involved in ARHL, from cellular processes involved in ageing as senescence and autophagy, to molecules essential for hearing as IGF-1 and neurotrophins. Neuroinflammation takes a central stage as an essential element in the progression of injury and cell loss, and a target for cell protection strategies. Neurogenesis is also essential to understand the adult cochlea self-repair potential. Finally, the mechanisms of action and the potential of novel therapies for hair cell repair and protection will be discussed along with drug delivery strategies.

Presbycusis. --- Vestibular apparatus. --- Deafness --- Etiology. --- Treatment. --- Hearing loss --- Audiology --- Ear --- Hearing disorders --- Hearing --- Equilibrium (Physiology) --- Labyrinth (Ear) --- Hearing loss in old age --- Presbyacousia --- Presbyacusia --- Presbyacusis --- Presbycusia --- Senile deafness --- Diseases --- Aging --- TGF-beta --- Noise --- Hair cells --- redox balance --- spiral ganglion neurons --- Drug delivery --- ARHL --- Auditory Cortex --- Lipid homeostasis --- Inner ear

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The Auditory Brain and Age-Related Hearing Impairment provides an overview of the interaction between age-related hearing impairments and cognitive brain function. This monograph elucidates the techniques used in the connectome and other brain-network studies based on electrophysiological methods. Discussions of the manifestations of age-related hearing impairment, the causes of degradation of sound processing, compensatory changes in the human brain, and rehabilitation and intervention are included. There is currently a surge in content on aging and hearing loss, the benefits of hearing aids and implants, and the correlation between hearing loss, cognitive decline and early onset of dementia. Given the changing demographics, treatment of age-related hearing impairment need not just be bottom-up (i.e., by amplification and/or cochlear implantation), but also top-down by addressing the impact of the changing brain on communication. The role of age-related capacity for audio-visual integration and its role in assisting treatment have only recently been investigated, thus this area needs more attention.--

Hearing disorders. --- Presbycusis. --- Cognition. --- Correction of Hearing Impairment. --- Aged. --- Auditory disorders --- Defective hearing --- Disorders of hearing --- Hearing defects --- Hearing impairments --- Communicative disorders --- Disabilities --- Ear --- Sensory disorders --- Diseases --- Elderly --- Geriatrics --- Longevity --- Audiologic Habilitation --- Audiologic Rehabilitation --- Aural Habilitation --- Aural Rehabilitation --- Correction of Hearing Loss --- Habilitation of Hearing Impaired --- Rehabilitation of Hearing Impairment --- Correction of Auditory Perception --- Habilitation of Hearing Impairment --- Hearing Impaired Rehabilitation --- Rehabilitation of Hearing Impaired --- Audiologic Habilitations --- Audiologic Rehabilitations --- Auditory Perception Correction --- Auditory Perception Corrections --- Aural Habilitations --- Aural Rehabilitations --- Habilitation, Audiologic --- Habilitation, Aural --- Habilitations, Audiologic --- Habilitations, Aural --- Hearing Impaired Habilitation --- Hearing Impaired Habilitations --- Hearing Impairment Correction --- Hearing Impairment Corrections --- Hearing Impairment Habilitation --- Hearing Impairment Habilitations --- Hearing Impairment Rehabilitation --- Hearing Impairment Rehabilitations --- Hearing Loss Correction --- Hearing Loss Corrections --- Impaired Habilitation, Hearing --- Impaired Habilitations, Hearing --- Impairment Correction, Hearing --- Impairment Corrections, Hearing --- Impairment Habilitation, Hearing --- Impairment Habilitations, Hearing --- Impairment Rehabilitation, Hearing --- Impairment Rehabilitations, Hearing --- Loss Correction, Hearing --- Loss Corrections, Hearing --- Perception Correction, Auditory --- Perception Corrections, Auditory --- Rehabilitation, Audiologic --- Rehabilitation, Aural --- Rehabilitation, Hearing Impaired --- Rehabilitations, Audiologic --- Rehabilitations, Aural --- Hearing Disorders --- Cognitive Function --- Cognitions --- Cognitive Functions --- Function, Cognitive --- Functions, Cognitive --- Presbycuses --- Hearing loss in old age --- Presbyacousia --- Presbyacusia --- Presbyacusis --- Presbycusia --- Senile deafness --- Deafness --- rehabilitation --- Aging