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Osteoporosis in women. --- Evidence-based medicine. --- Postmenopausal osteoporosis --- Women --- EBM (Medicine) --- Evidence-based healthcare --- Clinical medicine --- Systematic reviews (Medical research) --- Diseases --- Decision making

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René Rizzoli Menopause is the time in a woman’s life when reproductive capacity ends. Ovaries decrease their activity and the production of sex hormones ceases. This period may be associated with a large variety of symptoms affecting the cardiovascular and urogenital systems, as well as skin, hair and bone. Bone capital is accumulated by the end of the second decade and remains more or less constant up to the time of menopause. Sex hormone deficiency leads to accelerated bone turnover, a negative balance and microarchitectural deterioration, which compromises bone strength, thereby increasing bone fragility and, thus, fracture risk. By the age of 80, it is estimated that 50% of trab- ular bone will have been lost. Natural menopause occurs between the ages of 45 and 54 years all over the world. This age does not appear to have changed significantly over the centuries. In contrast, since the middle of the 19th century, life expectancy, particularly in women, has increased considerably, with most women living to the age of 80 years or more in many regions of the world. This means that at the age of 50 years, a woman will live for more than 30 years without bone protection by sex hormones. This r- resents more than one-third of a woman’s life. At the age of 50 years, the lifetime risk to experience a fracture is about 50% (ie, one out of two women will have a fracture during this period).

Menopause -- Hormone therapy. --- Osteoporosis in women. --- Osteoporosis, Postmenopausal. --- Medicine --- Health & Biological Sciences --- Musculoskeletal System Diseases --- Postmenopausal osteoporosis --- Medicine. --- Gynecology. --- Rheumatology. --- Orthopedics. --- Medicine & Public Health. --- Women --- Diseases --- Orthopaedics --- Orthopedia --- Surgery --- Gynaecology --- Generative organs, Female --- Internal medicine --- Connective tissues --- Joints --- Gynecology .

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Osteoporosis --- Osteoporosis. --- Turkey. --- Anatolia --- Anatolie --- Ānātūlī --- Asia Minor --- Asia Minore --- Bu̇gd Naĭramdakh Turk Uls --- Buturuki --- Cộng hoà Thổ Nhĩ Kỳ --- Dēmokratia tēs Tourkias --- Devlet-i Aliye Osmaniye --- Durka --- Durkka dásseváldi --- Gweriniaeth Twrci --- Jamhuri ya Uturuki --- Jamhuuriyada Turki --- Jumhūrīyah al-Turkīyah --- Komara Tirkiyeyê --- Lýðveldið Turkaland --- Lýðveldið Tyrkland --- Orílẹ̀-èdè Olómìnira ilẹ̀ Túrkì --- Osmanlı İmparatorluğu --- Osmanskai︠a︡ Imperii︠a︡ --- Ottoman Empire --- Pobblaght ny Turkee --- Poblacht na Tuirce --- Repóbblica d'l Turchî --- Repubbleche de Turchie --- Repubblica di Turchia --- Republic of Turkey --- Republic of Türkiye --- República da Turquia --- Republica de Turchia --- Republica de Turquía --- Republica Turcia --- Republiek Turkeye --- Republiek Turkije --- Republiek van Turkye --- Republik bu Tirki --- Republik Tierkei --- Republik Turkäi --- Republik Türkei --- Républik Turki --- Republik Turkia --- Republika e Turqisë --- Republika ng Turkiya --- Repùblika Tërecczi --- Republika Turcija --- Republika Turcji --- Republika Turcyje --- Republika Turecko --- Republika Turkiya --- Republika Turkojska --- Republika Turska --- Republika Turt︠s︡ii︠a︡ --- Republiḳah ha-Ṭurḳiyah --- Republiken Turkiet --- Republikken Tyrkia --- Republikken Tyrkiet --- République de Turquie --- République turque --- Repuvlika de Turkiya --- Ripablik kya Buturuki --- Ripoliku Turkiyakondre --- T.C. --- Tagduda n Tturk --- TC --- Teki --- Tëreckô --- Ṭerḳay --- Ṭerḳishe Republiḳ --- Thekhi --- Thổ Nhĩ Kỳ --- Thú-ngí-khì --- Tiakei --- Tierkei --- Tiki --- Tirki --- Tırkiya --- Tirkiye --- Ti︠u︡rk --- Ti︠u︡rk Respublika --- Ti︠u︡rkii︠a︡ --- Ti︠u︡rkii︠a︡ Respublika --- Tlacatlahtocayotl Turquia --- Tʻŏkʻi --- T'ŏk'i Konghwaguk --- Tʼóok Bikéyah --- Torkėjė --- Tȯrkiă --- Törkie --- Törkieë --- Tȯrkii︠a︡ --- Tȯrkii︠a︡ Jȯmḣu̇rii︠a︡te --- Török Köztársaság --- Törökország --- Toruko --- Toruko Kyōwakoku --- Tourkia --- Tourkikē Dēmokratia --- Tturk --- Tu er qi gong he guo --- Tū-ī-gì --- Tū-ī-gì Gê̤ṳng-huò-guók --- Tu'erqi --- Tu'erqi gong he guo --- Tu'erqi Gongheguo --- Tuirc --- Tunkī --- Turchî --- Turchia --- Turchie --- Turchy Respublikæ --- Turcia --- Turcija --- Turcijas Republika --- Turcja --- Turcland --- Turcyjo --- Turechchyna --- Turecká republika --- Turecko --- Tureke --- Turet︠s︡ka Respublika --- Turėtskai︠a︡ Rėspublika --- Tureuki --- Türgi --- Türgi Vabariik --- Türgü --- Türgü Vabariik --- Turk --- Turkäi --- Turkaland --- Turkamastor --- Türkän --- Turkanʹ respubliksʹ --- Turkee --- Türkei --- Turkeya --- Turkeye --- Turki --- Turkia --- Turkia Respubliko --- Turkieë --- Turkiet --- Turkii --- Tu̇rkii︠a︡ --- Tu̇rkii︠a︡ Respublikasy --- Tu̇rkiĭė --- Tu̇rkiĭė Respublikata --- Turkija --- Turkije --- Turkin tasavalta --- Turkio --- Turkiyā --- Turkiya Republika --- Türkiyä Respublikası --- Turkiyah --- Turkiyakondre --- Türkiye --- Türkiye Cumhuriyeti --- Türkiýe Respublikasy --- Turkki --- Turkojska --- Turkowska --- Turkujo --- Turkya --- Turkyah --- Turkye --- Turqia --- Turquía --- Turquie --- Turska --- Turtchie --- Turt︠s︡i --- Turt︠s︡i Respubliki --- Turt︠s︡iĭ --- Turt︠s︡ii︠a︡ --- Turtsyi︠a︡ --- Turukiya --- Tuykia --- Twrci --- Tyrkia --- Tyrkiet --- Tyrkland --- Tẏrt︠s︡i --- Uturuki --- Vysokai︠a︡ Porta --- Whenua Korukoru --- postmenopausal osteoporosis --- osteoporosis --- Bones --- Vitamin D deficiency --- Diseases --- Ānātūl --- Cộng hoà Thổ Nhĩ K --- Komara Tirkiyey --- Orílẹ̀-èdè Olómìnira ilẹ̀ Túrk --- Osmanskai͡a Imperii͡ --- Repóbblica d'l Turch --- Republika e Turqis --- Republika Turt͡sii͡ --- Tëreck --- Ṭerḳishe Republi --- Thổ Nhĩ K --- Thú-ngí-kh --- Ti͡urk --- Ti͡urk Respublika --- Ti͡urkii͡ --- Ti͡urkii͡a Respublika --- Torkėj --- Tȯrki --- Tȯrkii͡ --- Tȯrkii͡a Jȯmḣu̇rii͡ate --- Tū-ī-g --- Tunk --- Turch --- Turet͡ska Respublika --- Turėtskai͡a Rėspublika --- Türg --- Turkie --- Tu̇rkii͡ --- Tu̇rkii͡a Respublikasy --- Tu̇rkiĭ --- Turkiy --- Turt͡si --- Turt͡si Respubliki --- Turt͡sii͡ --- Turtsyi͡ --- Tẏrt͡si --- Vysokai͡a Porta --- Cộng hoà Thỏ̂ Nhĩ K --- Thỏ̂ Nhĩ K