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Nucleic acids. --- Polynucleotides --- Biomolecules

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This volume includes comprehensive and up-to-date coverage of all nucleic acid-specific steps used in X-ray crystallography, from macromolecule production to structure determination. Chapters dedicated to RNA preparation and crystallogenesis will be of interest to beginners, while chapters focused on data collection, phasing and refinement will be particularly useful to researchers with a higher level of expertise. Several functional case studies are also presented in the last part of the book. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.   Authoritative and thorough, Nucleic Acid Crystallography: Methods and Protocols presents protocols that are aimed at both researchers and students who are interested in the structural biology of DNA or RNA, alone or in complex with proteins or ligands.  .

Nucleic acids. --- Nucleic Acid Chemistry. --- Polynucleotides --- Biomolecules

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Nucleic acids --- Polynucleotides --- Biomolecules --- Nucleic acids. --- Nucleic Acids.

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This unique and practical resource provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussion of x-ray crystallography, NMR, molecular modelling, and databases. Its focus is on a survey of structures especially important for biomedical research and pharmacological applications. To aid novices, the book includes an introduction to technical lingo used to describe nucleic acid structure and conformations (roll, slide, twist, buckle, etc.). This completely updated edition features expanded coverage of the latest

Nucleic acids. --- Biomolecules. --- Biological molecules --- Molecules --- Molecular biology --- Polynucleotides --- Biomolecules

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Nucleic acids --- Molecular dynamics. --- Computer simulation. --- Dynamics, Molecular --- Dynamics --- Polynucleotides --- Biomolecules