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Article
Schedule induced polydipsia experience decreases plasma corticosterone levels but increases plasma prolactin levels.
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Year: 1988

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Plasma corticosterone levels as a function of cross-species fostering and species differences.

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Attenuation of amphetamine-stereotypy by mesostriatal dopamine depletion enhances plasma corticosterone: Implications for stereotypy as a coping response.
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Year: 1989

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Mice reared with rat aunts: effect on plasma corticosterone and open field activity.

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Mice reared with rat aunts: effects in adulthood upon plasma corticosterone and open-field activity.

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Modification of the plasma corticosterone response as a function of infantile stimulation and electric shock parameters.

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Male Purdue-Wistar rats were handled for 20 days in infancy or were not disturbed (total N = 324). In adulthood these animals were subdivided and exposed to one of three electric shock intensities (0.2, 0.5, or 0.8 mA) for durations of 2, 5, 10, 15, 30, or 60 min. Following the termination of shock, the animals were killed immediately, 5 min afterwards, or 15 min afterwards; and the free plasma corticosterone was assayed. Both duration of shock and time between shock termination and decapitation affected the magnitude of the corticoid response; these effects were additive and permit the general conclusion that the major parameter is total time between shock onset and killing. Rats handled in infancy were found to have a greater amount of plasma corticosterone at the time that shock was terminated, but their rate of release of corticosterone during the subsequent 15 min was less than that of nonhandled controls.


Article
Nesting Material as Environmental Enrichment Has No Adverse Effects on Behavior and Physiology of Laboratory Mice.

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Environmental enrichment may improve the quality of life of captive animals by altering the environment of animals so that they are able to perform more of the behavior that is within the range of the animal's species-specific repertoire. When enrichment is introduced into an animal's environment, it is important to evaluate the effect of the enrichment program and to assess whether the animal continues to use the enrichment in the long-term. Groups of mice were housed under either standard or enriched conditions for several weeks. Nesting material which was highly preferred in previous studies was used as enrichment. During the period of differential housing several behavioral parameters (behavioral tests and handling) and physiological parameters (urine and plasma corticosterone, food and water intake, body and adrenal weight) were monitored to determine the impact of environmental enrichment. Observations were made to determine whether or not the mice continued to use the enrichment. The results indicated that throughout the study all mice used the nesting material to build nests and that mice from enriched conditions weighed more than mice housed under standard conditions, although the latter consumed more food. No major differences for behavioral and physiological parameters were found between the groups of mice housed under different conditions. Therefore it is not likely that supply of nesting material will jeopardize the outcome of experiments.


Article
Immune and endocrine aspects of physical and social environmental variations in groups of male rabbits in seminatural conditions.
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Year: 2000

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Endocrine and immune parameters, namely glucocorticoid receptors (GcR) and IFN-gamma production in peripheral blood mononuclear cells (PBMC), and corticosterone in plasma, were studied in groups of four male rabbits observed in seminatural conditions in relation to agonistic behaviour and to seasonal variations. These parameters were selected on the basis of the findings that the presence of GcR in PBMC gives an indication of the in vivo biological effects of glucocorticoids and that PBMC cytokine production and plasma corticosterone are related to social behaviour. The frequency of active and passive behaviours was used to rank the animals. Seasonal variations were present for agonistic behaviours (Attack, Follow, Chase) and For plasma corticosterone, which were significantly higher in winter. IFN-gamma production in PBMC was increased after social interactions in both seasons, while plasma corticosterone was increased only in winter: GcR capacity in PBMC was decreased after social interactions. The results indicate that social and physical environmental factors are correlated with immune-endocrine functions


Article
The rank assessed in a food competition test influences subsequent reactivity to immune and social challenges in mice.
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Year: 2004

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The purpose of this study was to investigate whether, in a stable social environment, social interactions are responsible for individual, endocrine and immune differences among group members. Cage-mates were classified according to their rank in a food competition test. The influence of the rank was evaluated in two different situations activating neuroendocrine and immune systems. A first experiment used a context of repeated social stress. A second experiment investigated the influence of rank on the response to a bacterial infection by BCG. Endocrine and immune functions were assessed by measuring plasma corticosterone levels, splenocyte proliferation and in vitro cytokine production. In control undisturbed groups, plasma levels of corticosterone were lower in low ranking (LR) mice than in intermediate (IR) and high ranking (HR) mice. LPS-induced splenocyte proliferation and in vitro cytokine production were independent of rank. In response to social stress, corticosterone increased similarly in all categories but the increase in splenocyte proliferation was more pronounced in HR animals. During BCG infection, the rank influenced the production of IL-10 and IFN-gamma by tuberculin-stimulated splenocytes during the acute phase of the infection but not after 94 days of infection. Cytokine production in response to LPS and bacterial growth were not affected by the rank. Therefore, social interactions emerging in a stable social group may be involved in the individual differences observed in endocrine activity and in immune system reactivity. (C) 2004 Elsevier Inc. All rights reserved


Article
Age and weight at weaning affect corticosterone level and development of stereotypies in ICR-mice.
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Year: 1997

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Artificial weaning in laboratory mice elicits increased levels of exploratory and escape behaviour. Under barren housing conditions patterns of exploration and escape subsequently develop into stereotypic behaviour. Weaning weight in wild house mice, Mus musculus domesticus, is known to affect offspring fitness, thus reduced weaning weight represents a risk to fitness. In male ICR-mice, Mus musculus, precocious weaning 3 days prior to standard weaning age tended to decrease growth rate in the long term, and differences in weaning weight of mice weaned at the standard age persisted into adulthood. Both plasma corticosterone levels 48 h after weaning and adult stereotypy levels were higher in precociously weaned mice, but also in animals weaned at the usual age but at a low weight. These results suggest that potential costs in terms of fitness may affect stress levels at the onset of stereotypy development and predispose ICR-mice to perform stereotypies at a high level when adult. (C) 1997 The Association for the Study of Animal Behaviour

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