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Plasma confinement. --- Plasma stability. --- Plasma instabilities.

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The essential introduction to magnetic reconnection—written by a leading pioneer of the fieldPlasmas comprise more than 99 percent of the visible universe; and, wherever plasmas are, magnetic reconnection occurs. In this common and yet incompletely understood physical process, oppositely directed magnetic fields in a plasma meet, break, and then reconnect, converting the huge amounts of energy stored in magnetic fields into kinetic and thermal energy. In Magnetic Reconnection, Masaaki Yamada offers an illuminating synthesis of modern research and advances on this important topic. Magnetic reconnection produces such phenomena as solar flares and the northern lights, and occurs in nuclear fusion devices. A better understanding of this crucial cosmic activity is essential to comprehending the universe and varied technological applications, such as satellite communications. Most of our knowledge of magnetic reconnection comes from theoretical and computational models and laboratory experiments, but space missions launched in recent years have added up-close observation and measurements to researchers’ tools. Describing the fundamental physics of magnetic reconnection, Yamada connects the theory with the latest results from laboratory experiments and space-based observations, including the Magnetic Reconnection Experiment (MRX) and the Magnetospheric Multiscale (MMS) Mission. He concludes by considering outstanding problems and laying out a road map for future research.Aimed at advanced graduate students and researchers in plasma astrophysics, solar physics, and space physics, Magnetic Reconnection provides cutting-edge information vital area of scientific investigation.

Magnetic reconnection. --- SCIENCE / Physics / Magnetism. --- Acceleration. --- Accretion disk. --- Ampere. --- Annihilation. --- Astrophysical plasma. --- Astrophysics. --- Bremsstrahlung. --- Collision frequency. --- Collisionality. --- Coronal loop. --- Coronal mass ejection. --- Coulomb collision. --- Current density. --- Current sheet. --- Cyclotron. --- Debye length. --- Diffusion layer. --- Dissipation. --- Drift velocity. --- Dynamo theory. --- Electric field. --- Electrical resistivity and conductivity. --- Electron temperature. --- Electrostatics. --- Energy transformation. --- Experimental physics. --- Fermi acceleration. --- Feynman diagram. --- Field effect (semiconductor). --- Field line. --- Fine structure. --- Flux tube. --- Fusion power. --- Gauge theory. --- Gyroradius. --- Hall effect. --- Inductance. --- Induction equation. --- Instability. --- Interferometry. --- Ion acoustic wave. --- Ionization. --- Kinetic theory of gases. --- Kink instability. --- Landau damping. --- Langmuir probe. --- Length scale. --- Lorentz force. --- Madison Symmetric Torus. --- Magnetar. --- Magnetic confinement fusion. --- Magnetic diffusivity. --- Magnetic dipole. --- Magnetic energy. --- Magnetic field. --- Magnetic flux. --- Magnetic helicity. --- Magnetization. --- Magnetohydrodynamics. --- Magnetopause. --- Magnetosheath. --- Magnetosonic wave. --- Magnetosphere. --- Maxwell–Boltzmann distribution. --- Mean free path. --- Momentum transfer. --- Neutral beam injection. --- Nonlinear optics. --- Nuclear fusion. --- Paramagnetism. --- Particle physics. --- Pitch angle (particle motion). --- Plasma (physics). --- Plasma acceleration. --- Plasma oscillation. --- Plasma parameter. --- Plasma parameters. --- Plasma stability. --- Plasmoid. --- Quadrupole. --- Relativistic plasma. --- Reversed field pinch. --- Safety factor (plasma physics). --- Scattering. --- Skin effect. --- Solar flare. --- Spacecraft. --- Spatial scale. --- Spheromak. --- Stark effect. --- Substorm. --- Synchrotron radiation. --- Thermodynamic equilibrium. --- Thomson scattering. --- Tokamak. --- Two-dimensional space. --- Van Allen radiation belt. --- Weibel instability. --- X-ray. --- Annihilation, Magnetic field --- Magnetic field annihilation --- Magnetic field line merging --- Merging, Magnetic field line --- Reconnection, Magnetic --- Reconnection (Astronomy) --- Astrophysics --- Geophysics --- Magnetic fields

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The interest in opioids such as morphine, the prototypical opioid ligand, has been maintained through the years. The identification of endogenous opioids and their receptors (mu, delta, kappa, and nociceptin), molecular cloning, and the elucidation of the crystal structures of opioid receptors represent key milestones in opioid research. The opioid system modulates numerous pharmacological responses, with therapeutic (i.e., analgesia) and detrimental side effects (i.e., addiction). The medical use and misuse of opioids have dramatically increased, leading to the 21st century opioid crisis. This book presents recent developments in opioid drug discovery, specifically in the medicinal chemistry and pharmacology of new ligands targeting the opioid receptors as effective and safe therapeutics for human diseases. Furthermore, it draws a special attention to advancing concepts and strategies in opioid drug discovery to mitigate opioid liabilities. The diversity among the discussed topics is a testimony to the complexity of the opioid system, which results from the expression, regulation, and functional role of ligands and receptors. The array of multidisciplinary research areas illustrates the rapidly developing basic research and translational activities in opioid drug discovery. This book will serve as a useful reference while also stimulating continued research in the chemistry and pharmacology of opioids and their receptors, with the prospect of developing improved therapies for human diseases, but also improving health and quality of life in general.

Medicine --- opioid receptors --- neurokinin-1 receptor --- peptide synthesis --- receptor binding studies --- functional assay --- writhing test --- tolerance --- Leu-enkephalin --- beta-arrestin --- mu opioid receptor --- delta opioid receptor --- biased signaling --- DADLE --- ischemia --- plasma stability --- morphinan --- BNTX --- δ opioid receptor antagonist --- 1H-NMR experiments --- mechanism elucidation --- peripheral antinociception --- 14-methoxycodeine-6-O-sulfate --- codeine-6-O-sulfate --- opioid peptides and peptidomimetics --- DAMGO --- DALDA --- [Dmt1]DALDA --- KGOP01 --- binding --- molecular docking --- structure-activity relationships --- β2-amino acids --- β2-Homo-amino acids --- µ-opioid receptor --- opioid peptides --- TAPP --- racemic synthesis of β2-amino acids --- peripheral µ-opioid receptors --- analgesia --- peripheral analgesic tolerance --- dysbiosis --- opioid --- bifunctional ligands --- (−)-N-phenethylnorhydromorphone analogs --- [35S]GTPgammaS assay --- forskolin-induced cAMP accumulation assays --- β-arrestin recruitment assays --- MOR and DOR agonists --- respiratory depression --- bias factor --- molecular modeling &amp --- simulation --- δ opioid receptor --- NTI derivative --- sulfonamide --- inverse agonist --- neutral antagonist --- agonist --- opioids --- mu receptor --- opioid side effects --- biased agonism --- partial agonism --- zerumbone --- chronic constriction injury (CCI) --- allodynia --- hyperalgesia --- potassium channels --- over-the-counter drugs --- misuse --- abuse --- opioid drugs --- pharmacology --- codeine --- dihydrocodeine --- loperamide --- opioid peptide --- macrocyclic tetrapeptide --- multifunctional ligands --- kappa opioid receptor --- analgesics --- opioid liabilities --- μ opioid receptor --- receptor model --- biased ligands --- dependence --- pain therapy --- neonatal opioid withdrawal syndrome --- naltrexone --- 6β-naltrexol --- buprenorphine --- G-protein bias --- arrestin recruitment --- respiration --- mitragynine --- heteromer --- internalization --- primary hippocampal culture --- lysosomes --- µ opioid receptor --- molecular dynamics --- docking --- interaction fingerprints --- biased agonists --- SR-17018 --- PZM21 --- morphine --- fentanyl --- diphenethylamines --- design and synthesis --- structure-activity relationships --- partial agonist --- biased agonist --- antagonist --- binding affinity --- selectivity --- opioid receptors --- neurokinin-1 receptor --- peptide synthesis --- receptor binding studies --- functional assay --- writhing test --- tolerance --- Leu-enkephalin --- beta-arrestin --- mu opioid receptor --- delta opioid receptor --- biased signaling --- DADLE --- ischemia --- plasma stability --- morphinan --- BNTX --- δ opioid receptor antagonist --- 1H-NMR experiments --- mechanism elucidation --- peripheral antinociception --- 14-methoxycodeine-6-O-sulfate --- codeine-6-O-sulfate --- opioid peptides and peptidomimetics --- DAMGO --- DALDA --- [Dmt1]DALDA --- KGOP01 --- binding --- molecular docking --- structure-activity relationships --- β2-amino acids --- β2-Homo-amino acids --- µ-opioid receptor --- opioid peptides --- TAPP --- racemic synthesis of β2-amino acids --- peripheral µ-opioid receptors --- analgesia --- peripheral analgesic tolerance --- dysbiosis --- opioid --- bifunctional ligands --- (−)-N-phenethylnorhydromorphone analogs --- [35S]GTPgammaS assay --- forskolin-induced cAMP accumulation assays --- β-arrestin recruitment assays --- MOR and DOR agonists --- respiratory depression --- bias factor --- molecular modeling &amp --- simulation --- δ opioid receptor --- NTI derivative --- sulfonamide --- inverse agonist --- neutral antagonist --- agonist --- opioids --- mu receptor --- opioid side effects --- biased agonism --- partial agonism --- zerumbone --- chronic constriction injury (CCI) --- allodynia --- hyperalgesia --- potassium channels --- over-the-counter drugs --- misuse --- abuse --- opioid drugs --- pharmacology --- codeine --- dihydrocodeine --- loperamide --- opioid peptide --- macrocyclic tetrapeptide --- multifunctional ligands --- kappa opioid receptor --- analgesics --- opioid liabilities --- μ opioid receptor --- receptor model --- biased ligands --- dependence --- pain therapy --- neonatal opioid withdrawal syndrome --- naltrexone --- 6β-naltrexol --- buprenorphine --- G-protein bias --- arrestin recruitment --- respiration --- mitragynine --- heteromer --- internalization --- primary hippocampal culture --- lysosomes --- µ opioid receptor --- molecular dynamics --- docking --- interaction fingerprints --- biased agonists --- SR-17018 --- PZM21 --- morphine --- fentanyl --- diphenethylamines --- design and synthesis --- structure-activity relationships --- partial agonist --- biased agonist --- antagonist --- binding affinity --- selectivity