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This volume surveys the chemistry, biochemistry, biosynthesis, metabolism and pharmacological properties of lectins. Lectins, which are most commonly found in plants, are widespread natural products with striking biological activities. Their specific ability to recognise and bind to simple or complex saccharides facilitates their role as effective information protein molecules. As agents of cell-to-cell recognition, lectins promote symbiosis between plants and specific nitrogen-fixing soil bacteria. As natural defensive molecules, they can protect plants against predators such as bacteria, fungi and insects. As part of our diet, lectins are powerful exogenous growth factors in the small intestine and influence our health, the digestive function and the bacterial ecology of the alimentary tract. Lectins are also important research tools in preparative biochemistry and cell science.

Plant lectins. --- Plant lectins --- Physiological effect.

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Lectins. --- 57.083.33 --- Lectins --- Plant lectins --- #WPLT:bioc --- Phytolectins --- Plant proteins --- Protectins --- Receptor-specific proteins --- Hemagglutinin --- Immunoglobulins --- Isolectin --- Animal Lectins --- Isolectins --- Lectins, Animal --- Serological reactions --- Plant lectins. --- 57.083.33 Serological reactions --- Animal Lectin --- Lectin --- Lectin, Animal

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The intent of this volume of Current Topics in Microbiology and Immunology was to bring together a collection of in-depth and cutting edge reviews that highlight our current understanding of the biology of ricin and Shiga toxin (Stx), with the long term goal of advancing the development of countermeasures against these toxic agents.  In May of 2011, Western Europe experienced a severe outbreak of Stx-producing E. coli (STEC) that culminated in more than 3200 cases and 39 deaths.  While Stx is not the only virulence factor associated with STEC, it is certainly the primary determinant associated with the onset of hemolytic uremic syndrome (HUS).  At the present time, there are no clinically approved measures to neutralize Stx in individuals suffering from STEC infection.  Nor are there any preventatives or therapeutics for ricin toxin.  Although incidents of ricin exposure are largely unheard of, federal agencies and public health officials consider it a significant threat.  It is well documented that domestic and international terrorist groups have stockpiled, and in some cases weaponized ricin with the intent of releasing it into the public sphere and causing panic, illness and/or death on a local, regional, or possibly national scale. As the title of this volume indicates, the chapters, written by leading experts in the field, are organized so as to cover all aspects of ricin and Stx, including pathogenesis, immunity, vaccines and therapeutics. This outstanding collection of reviews will serve as an important and readily accessible resource for the research community in the coming years.   .

Antigens and antibodies. --- Chemical agents (Munitions) -- Toxicology. --- Ricin. --- Toxins. --- Verocytotoxins. --- Ricin --- Verocytotoxins --- Chemical agents (Munitions) --- Immunoglobulins --- Ribosome Inactivating Proteins, Type 2 --- Enterotoxins --- Plant Lectins --- Bacterial Toxins --- Albumins --- Ribosome Inactivating Proteins --- Proteins --- Toxins, Biological --- Lectins --- Biological Factors --- N-Glycosyl Hydrolases --- Amino Acids, Peptides, and Proteins --- Plant Proteins --- Glycoside Hydrolases --- Chemicals and Drugs --- Hydrolases --- Enzymes --- Enzymes and Coenzymes --- Shiga Toxins --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Pharmacy, Therapeutics, & Pharmacology --- Toxicology --- Immunotherapy. --- Vaccines. --- Therapeutic immunology --- Natural toxicants --- Toxicants, Natural --- Toxins and antitoxins --- Castor bean lectin --- Ricinus lectin --- Medicine. --- Pharmacology. --- Biomedicine. --- Pharmacology/Toxicology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Physiological effect --- Biologicals --- Clinical immunology --- Therapeutics --- Antigens --- Metabolites --- Poisons --- Antitoxins --- Detoxification (Health) --- Plant lectins --- Plant toxins --- Toxalbumins --- Toxicology. --- Medicine --- Pharmacology --- Poisoning