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Article
PDE4 cAMP-specific phosphodiesterases
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Year: 2001

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Article
The molecular biology of cyclic nucleotide phosphodiesterases
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Year: 2000

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Article
Cyclic nucleotide phosphodiesterases : relating structure and function
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Year: 2001

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Dissertation
Polyphosphoinositide phosphodiesterase : characterization and physiological significance in brain
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Year: 1984 Publisher: Utrecht Elinkwijk

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Phosphodiesterase inhibitors
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ISBN: 0122107209 9780122107207 9780080538815 0080538819 1281058971 9781281058973 9786611058975 Year: 1996 Publisher: San Diego Academic Press

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Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s, various PDE isoenzymes were defined which led to the development of the second generation of PDE inhibitors. Currently a variety of these new inhibitors are under test as potential anti-inflammatory drugs. During the past five years, molecular biology has revealed a superfamily of these phosphodiesterase isoenzymes. This book summarizes the present state of knowledge, as well as giving a comprehensive description of the compounds availab


Dissertation
Excitatory amino acids in nerve cell development and neuronal plasticity : focus on metabotropic glutamate receptors
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Year: 1993 Publisher: S.l. s.n.

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Book
Phosphodiesterases: CNS Functions and Diseases
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ISBN: 3319588117 3319588095 Year: 2017 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic neucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthiritis.  This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases.  The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.


Book
Hot topics in neural membrane lipidology
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ISBN: 1441918825 0387096922 9786612126406 1282126407 0387096930 3540096922 364281400X 3642813984 Year: 2009 Volume: 16 Publisher: New York : Springer,

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Not only do glycerophospholipid, sphingolipid, and cholesterol-derived lipid mediators facilitate the transfer of messages from one cell to another, they also facilitate communication among subcellular organelles. Hot Topics in Neural Membrane Lipidology provides readers with a cutting-edge, comprehensive review of these lipid mediators, their roles and association with neurological disorders, and the future direction of research on the topic. This monograph provides readers with critical data and is particularly accessible to neuroscience graduate students, teachers, and researchers. It can be used as a supplemental text for a range of neuroscience courses. Clinicians and pharmacologists will find this book useful for understanding molecular aspects of lipid mediators in acute neural trauma like stroke, spinal cord trauma, head injury, and neurodegenerative diseases such as Alzheimer disease, Parkinson disease, and Huntington disease. About the Author: Akhlaq A. Farooqui is a leader in the field of brain phospholipases A2, bioactive ether lipid metabolism, and glutamate-mediated neurotoxicity. He has discovered the stimulation of plasmalogen-selective phospholipase A2 activity in brains from patients with Alzheimer disease, and published cutting edge research on the generation and identification of glycerophospholipid, sphingolipid, and cholesterol-derived lipid mediators in kainic acid neurotoxicity. Dr. Farooqui has authored three monographs: Glycerophospholipids in Brain: Phospholipase A2 in Neurological Disorders (2007); Neurochemical Aspects of Excitotoxicity (2008); and Metabolism and Functions of Bioactive Ether Lipids in Brain (2008). All monographs are published by Springer, New York.

Keywords

Cell membranes. --- Electronic structure --Congresses. --- Membrane lipids. --- Neurons. --- Phospholipases. --- Phospholipids. --- Selenium --Congresses. --- Sphingolipids. --- Tellurium --Congresses. --- Membrane lipids --- Cell membranes --- Neurons --- Sphingolipids --- Phospholipids --- Phospholipases --- Membrane Lipids --- Neurotoxins --- Lipids --- Noxae --- Carboxylic Ester Hydrolases --- Phosphoric Diester Hydrolases --- Esterases --- Toxic Actions --- Chemicals and Drugs --- Hydrolases --- Chemical Actions and Uses --- Enzymes --- Enzymes and Coenzymes --- Animal Biochemistry --- Neurology --- Medicine --- Human Anatomy & Physiology --- Health & Biological Sciences --- Phosphatides --- Nerve cells --- Neurocytes --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- 538.91 <063> --- Biological models --- Modèles biologiques --- Modèles biologiques --- Medicine. --- Neurosciences. --- Neurochemistry. --- Neurology. --- Psychopharmacology. --- Biomedicine. --- 538.93 <063> --- 538.91 <063> Structures, including transitions--Congressen --- Structures, including transitions--Congressen --- 538.93 <063> Transport processes (except in quantum liquids and solids)--Congressen --- Transport processes (except in quantum liquids and solids)--Congressen --- Solid state physics --- Sphingosine --- Phosphates --- Cells --- Nervous system --- Membranes (Biology) --- Glycocalyces --- Endocrinology --- Mathematical models --- Data processing --- Endocrinologie --- Modèles mathématiques --- Behavioral pharmacology --- Drugs --- Chemotherapy --- Pharmacology --- Psychotropic drugs --- Neuropsychiatry --- Biochemistry --- Neurosciences --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Psychotropic effects --- Diseases --- Neurology .

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