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Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field. Volume II extends into the role of phosphoinositides in membrane organization and vesicular traffic. Endocytosis and exocytosis are modulated by phosphoinositides, which determine the fate and activity of integral membrane proteins. Phosphatidylinositol(4,5)-bisphosphate is a prominent flag in the plasma membrane, while phosphatidylinositol-3-phosphate decorates early endosomes. The Golgi apparatus is rich in phosphatidylinositol-4-phosphate, stressed cells increase phosphatidylinositol(3,5)-bisphosphate, and the nucleus has a phosphoinositide metabolism of its own. Phosphoinositide-dependent signaling cascades and the spatial organization of distinct phosphoinositide species are required in organelle function, fission and fusion, membrane channel regulation, cytoskeletal rearrangements, adhesion processes, and thus orchestrate complex cellular responses including growth, proliferation, differentiation, cell motility, and cell polarization. The two volumes on “Phosphoinositides” provide a concise overview of the latest developments in the field of phosphoinositide hemostasis and function, and provide introductory background and extensions into unexplored territory.

Biomedicine. --- Human genetics. --- Medical genetics. --- Medicine. --- Neurochemistry. --- Neurosciences. --- Phosphoinositides. --- Glycerophospholipids --- Cell Physiological Processes --- Biochemical Processes --- Chemical Processes --- Biochemical Phenomena --- Cell Physiological Phenomena --- Phosphatidic Acids --- Chemical Phenomena --- Glycerophosphates --- Phenomena and Processes --- Phospholipids --- Membrane Lipids --- Lipids --- Chemicals and Drugs --- Signal Transduction --- Phosphatidylinositols --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Phosphoinsitides. --- Molecular biology. --- Biomedicine general. --- Human Genetics. --- Molecular Medicine. --- Gene Function. --- Biochemistry --- Neurosciences --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Neural sciences --- Neurological sciences --- Neuroscience --- Nervous system --- Clinical sciences --- Medical profession --- Life sciences --- Physicians --- Genetic aspects --- Health Workforce --- Biomedicine, general. --- Molecular biochemistry --- Molecular biophysics --- Biophysics --- Biomolecules --- Systems biology --- Medicine --- Biology --- Biomedical Research. --- Neuroscience. --- Medical Genetics. --- Research. --- Biological research --- Biomedical research

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The central role of RNA in many cellular processes, in biotechnology, and as pharmaceutical agents, has created an interest in experimental methods applied to RNA molecules. This book provides scientists with a comprehensive collection of thoroughly tested up-to-date manuals for investigating RNA-protein complexes in vitro. The protocols can be performed by researchers trained in standard molecular biological techniques and require a minimum of specialized equipment. The procedures include recommendation of suppliers of reagents.

Analytical biochemistry --- Neoplastic Processes --- Pathologic Processes --- Neoplasms --- Pathological Conditions, Signs and Symptoms --- Diseases --- Neoplasm Metastasis --- Metastases, Neoplasm --- Metastasis, Neoplasm --- Neoplasm Metastases --- Metastase --- Metastasis --- Metastases --- Symptoms and General Pathology --- Benign Neoplasms --- Malignancy --- Malignant Neoplasms --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Malignant Neoplasm --- Neoplasias --- Neoplasm, Benign --- Neoplasm, Malignant --- Neoplasms, Malignant --- Tumor --- Medical Oncology --- Pathological Processes --- Processes, Pathologic --- Processes, Pathological --- Processes, Neoplastic --- secondary --- Inositol phosphates. --- Inositol phosphates - Laboratory manuals. --- Phospholipids - Laboratory manuals. --- Phospholipids. --- Glycerophospholipids --- Phosphotransferases (Alcohol Group Acceptor) --- Investigative Techniques --- Phosphotransferases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Phosphatidic Acids --- Transferases --- Glycerophosphates --- Enzymes --- Phospholipids --- Enzymes and Coenzymes --- Membrane Lipids --- Chemicals and Drugs --- Lipids --- Phosphatidylinositol 3-Kinases --- 1-Phosphatidylinositol 4-Kinase --- Phosphatidylinositols --- Clinical Laboratory Techniques --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Clinical Laboratory Diagnoses --- Clinical Laboratory Testings --- Clinical Laboratory Tests --- Diagnoses and Laboratory Examinations --- Diagnosis, Laboratory --- Laboratory Diagnosis --- Laboratory Examinations and Diagnoses --- Laboratory Techniques, Clinical --- Clinical Laboratory Technique --- Clinical Laboratory Test --- Clinical Laboratory Testing --- Diagnose, Clinical Laboratory --- Laboratory Diagnoses --- Laboratory Technique, Clinical --- Laboratory Test, Clinical --- Laboratory Testing, Clinical --- Technique, Clinical Laboratory --- Test, Clinical Laboratory --- Testing, Clinical Laboratory --- Laboratories --- Medical Laboratory Science --- Clinical Laboratory Services --- Inositide Phospholipids --- Inositol Phospholipids --- Phosphatidyl Inositol --- Phosphatidylinositol --- Inositide Phospholipid --- Inositol Phosphoglyceride --- Inositol Phosphoglycerides --- Inositol Phospholipid --- Phosphoinositide --- Phosphoinositides --- PtdIns --- Inositol, Phosphatidyl --- Phosphoglyceride, Inositol --- Phosphoglycerides, Inositol --- Phospholipid, Inositide --- Phospholipid, Inositol --- Phospholipids, Inositide --- Phospholipids, Inositol --- PI 4-Kinase --- Phosphatidylinositiol Kinase --- Phosphatidylinositol Kinase Type II --- Phosphoinositide Kinase --- Phosphatidylinositol 4-Kinase --- PtdIns 4-Kinase --- 1 Phosphatidylinositol 4 Kinase --- Kinase, Phosphatidylinositiol --- Kinase, Phosphoinositide --- PI 4 Kinase --- Phosphatidylinositol 4 Kinase --- PtdIns 4 Kinase --- PI 3-Kinase --- PI-3K --- PI3 Kinases --- PI3-Kinase --- Phosphoinositide 3 Kinases --- Phosphoinositide 3-Hydroxykinase --- PtdIns 3-Kinases --- PI-3 Kinase --- Phosphatidylinositol-3-OH Kinase --- PtdIns 3-Kinase --- 3-Hydroxykinase, Phosphoinositide --- Kinase, PI-3 --- Kinase, Phosphatidylinositol-3-OH --- Kinases, PI3 --- Kinases, Phosphoinositide 3 --- PI 3 Kinase --- PI3 Kinase --- Phosphatidylinositol 3 Kinases --- Phosphatidylinositol 3 OH Kinase --- Phosphoinositide 3 Hydroxykinase --- PtdIns 3 Kinase --- PtdIns 3 Kinases --- Lipid --- Cell Membrane Lipid --- Cell Membrane Lipids --- Membrane Lipid --- Lipid, Cell Membrane --- Lipid, Membrane --- Lipids, Cell Membrane --- Lipids, Membrane --- Membrane Lipid, Cell --- Membrane Lipids, Cell --- Cell Membrane --- Membranes --- Coenzymes and Enzymes --- Phosphatides --- Phospholipid --- Biocatalysts --- Biocatalyst --- Enzyme --- Molecular Mechanisms of Pharmacological Action --- Calcium Glycerophosphate --- Glycerolphosphates --- Glycerolphosphate --- Glycerophosphate --- Glycerophosphate, Calcium --- Transferase --- Ammonium Phosphatidate --- Diacylglycerophosphates --- Phosphatidic Acid --- Acid, Phosphatidic --- Acids, Phosphatidic --- Phosphatidate, Ammonium --- Kinase --- Kinases --- Phosphotransferases, ATP --- Transphosphorylases --- ATP Phosphotransferases --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Glycerophospholipid --- Phosphoglyceride --- Phosphoglycerides --- 616-006.6 --- 616-006.6 Malignant epithelial tumours. Carcinomata. Cancer --- Malignant epithelial tumours. Carcinomata. Cancer --- Cancer metastasis --- Dissemination of cancer --- Metastatic cancer --- Neoplasm metastasis --- Spread of cancer --- Tumor dissemination --- Tumor metastasis --- Tumor spread --- Pathology --- Cancer invasiveness --- Cancer of unknown primary origin --- Research --- Methodology --- Dissemination --- 57.08 --- 57.08 Biological techniques. Experimental methods. Equipment --- Biological techniques. Experimental methods. Equipment --- Isoelectric focusing. --- Hydrogen-ion concentration. --- Hydrogen-ion activity --- pH (Chemistry) --- Acidity function --- Electrofocusing --- Focusing, Isoelectric --- Analytical chemistry --- Chemistry, Organic --- Electrophoresis --- Qualitative --- Nucleic acid hybridization. --- Nucleic acid probes. --- Oligonucleotide probes --- Probes, Nucleic acid --- Molecular probes --- Cytogenetics --- Cytology --- Hybridization --- Technique --- RNA-protein interactions --- Interactions, RNA-protein --- Protein-RNA interactions --- RNA-protein binding --- Protein binding --- RNA-protein interactions. --- Nucleic Acids --- Amino Acids, Peptides, and Proteins --- Nucleic Acids, Nucleotides, and Nucleosides --- Chemical Phenomena --- Proteins --- RNA --- Chemistry --- Physical Sciences & Mathematics --- Biochemistry --- Gene Products, RNA --- Non-Polyadenylated RNA --- RNA, Non-Polyadenylated --- Ribonucleic Acid --- Acid, Ribonucleic --- Non Polyadenylated RNA --- RNA Gene Products --- RNA, Non Polyadenylated --- Biopolymers --- Gene Products, Protein --- Gene Proteins --- Protein --- Protein Gene Products --- Proteins, Gene --- Chemical Phenomenon --- Chemical Process --- Physical Chemistry Phenomena --- Physical Chemistry Process --- Physicochemical Phenomenon --- Physicochemical Process --- Chemical Concepts --- Chemical Processes --- Physical Chemistry Concepts --- Physical Chemistry Processes --- Physicochemical Concepts --- Physicochemical Phenomena --- Physicochemical Processes --- Chemical Concept --- Chemistry Process, Physical --- Chemistry Processes, Physical --- Concept, Chemical --- Concept, Physical Chemistry --- Concept, Physicochemical --- Concepts, Chemical --- Concepts, Physical Chemistry --- Concepts, Physicochemical --- Phenomena, Chemical --- Phenomena, Physical Chemistry --- Phenomena, Physicochemical --- Phenomenon, Chemical --- Phenomenon, Physicochemical --- Physical Chemistry Concept --- Physicochemical Concept --- Process, Chemical --- Process, Physical Chemistry --- Process, Physicochemical --- Processes, Chemical --- Processes, Physical Chemistry --- Processes, Physicochemical --- Nucleic Acid --- Acid, Nucleic --- Acids, Nucleic --- Diagnostic Techniques and Procedures --- Analysis.