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The study of pharmacogenetics and pharmacogenomics focuses on how our genes and complex gene systems influence our response to drugs. Recent progress in clinical therapeutics has led to the discovery of new biomarkers that make it technically easier to identify groups of patients which are more or less likely to respond to individual therapies. The aim is to improve personalised medicine - not simply to prescribe the right medicine, but to deliver the right drug at the right dose at the right time. This textbook brings together leading experts to discuss the latest information on how human genetics impacts drug response phenotypes. It presents not only the basic principles of pharmacogenetics, but also clinically valuable examples that cover a broad range of specialties and therapeutic areas. This textbook is an invaluable introduction to pharmacogenetics and pharmacogenomics for health care professionals, medical students, pharmacy students, graduate students and researchers in the biosciences.

Pharmacogenetics. --- Pharmacogenomics.

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Agoraphobia --- Complementary Therapies --- Pharmacogenomics

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Pharmacogenomics --- Government policy

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This dissertation by Ingrid Jakobsen explores prognostic markers in acute myeloid leukemia (AML) through a candidate gene approach. It investigates the role of single nucleotide polymorphisms (SNPs) in genes like ABCB1, which affects drug resistance, and IDH1/2 mutations that impact treatment outcomes. The work aims to improve risk assessment and guide therapy by identifying genetic variations that influence AML treatment response and survival. Intended for medical researchers and healthcare professionals, this study emphasizes the importance of integrating genetic markers with existing clinical strategies to better predict patient outcomes and personalize AML treatment.

Acute myeloid leukemia. --- Pharmacogenomics.

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Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunities within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference. Multi-contributed book and chapters are written by contributors who are experts in their field. Provides perspectives from those involved in all aspects of pharmacogenomics-including academic, regulatory, economic, industry and medical-to illustrate how all of the pieces fit together and where the challenges may be. Includes case studies of both successful and unsuccessful applications so readers can consider the potential and challenges in moving the science into drug development and direct therapeutic applications. Chapters contain discussion questions and clinical pearls and enable readers to reflect on how to move pharmacogenomics forward and apply these observations and useful tips to their own work and research.

Pharmacogenomics. --- Pharmacogenomics --- Pharmacogenetics --- Pharmacological Phenomena --- methods. --- genetics. --- Genomes --- Effect of drugs on --- Pharmacogenetics.