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Peroxisomes are cell organelles that have functions for the provision of homeostasis and sustainable cellular health. They are indispensable for lipid metabolism and free radical detoxification. A disruption in the peroxisomal pathway can cause irreparable problems or death for the organism. This book provides a comprehensive overview of peroxisomes, including their role in cell health and diseases such as cancer.

Peroxisomes. --- Peroxidosomes --- Peroxysoma --- Microbodies

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Peroxisomes --- Glyoxysomes --- Cytochemistry --- Congresses --- 576.311.344 --- #WPLT:dd.prof.J.Vendrig --- Lysosomes. Peroxisomes. --- 576.311.344 Lysosomes. Peroxisomes. --- Peroxidosomes --- Peroxysoma --- Microbodies --- Cell organelles --- Cell chemistry --- Biochemistry --- Cytology --- Lysosomes. Peroxisomes --- Peroxisomes - Congresses --- Glyoxysomes - Congresses --- Cytochemistry - Congresses

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In eukaryotes, lipid metabolism requires the function of peroxisomes. These multitasking organelles are also part of species-specific pathways such as the glyoxylate cycle in yeast and plants or the synthesis of ether lipid in mammals. Proteins required for the biogenesis of peroxisomes typically assemble in large molecular complexes, which participate in membrane formation, protein transport, peroxisome duplication and - inheritance during cell division. Peroxisomal function is essential for life. Mutations in PEX genes, encoding for biogenesis factors, are often associated with lethal disorders. The association of peroxisomes with other organelles suggests an extensive participation in organellar crosstalk. This book represents a state-of-the-art review in the field of peroxisome research encompassing the cell and molecular biology of peroxisome biogenesis and its diseases, the protein complexes involved in this process and the modern technologies applied to study them. The book is intended for graduate students, researchers and lecturers in biochemistry, molecular and cell biology with a biomedical background.

Peroxisomes. --- Life sciences. --- Cytology. --- Biosciences --- Sciences, Life --- Science --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Peroxidosomes --- Peroxysoma --- Microbodies --- Cytology --- Cell membranes. --- Cell Biology. --- Biological Techniques. --- Membrane Biology. --- Research --- Methodology. --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Cell biology. --- Biology—Technique. --- Cell membranes .

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All three peroxisome proliferator-activated receptor (PPAR) subtypes share a high degree of structural homology while exhibiting differences in function, tissue distribution, and ligand specificity. In Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances, the authors trace the history of PPAR discovery and detail the receptor structure and its posttranslational modifications. Furthermore, endogenous ligands as well as various classes of exogenous ligands, subtype-selective, dual and pan agonists as well as antagonists, are discussed. In addition, the tissue distribution and versatile functions of PPAR subtypes in major organs are described.   As PPARs play critical roles as regulators of numerous physiological as well as pathophysiological pathways, Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances aims to help researchers to develop safer and more effective PPAR modulators as therapeutic agents to treat a myriad of diseases and conditions.

Life sciences. --- Peroxisome proliferator-Activated receptors. --- Peroxisomes -- Receptors. --- Peroxisomes --- Biological Science Disciplines --- Receptors, Cytoplasmic and Nuclear --- DNA-Binding Proteins --- Natural Science Disciplines --- Disciplines and Occupations --- Proteins --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Peroxisome Proliferator-Activated Receptors --- Physiology --- Pharmacology --- Chemistry --- Biology --- Health & Biological Sciences --- Physical Sciences & Mathematics --- Biochemistry --- Biology - General --- Receptors --- Peroxisomes. --- Hormone receptors. --- Hormones --- Receptors, Hormone --- Peroxidosomes --- Peroxysoma --- Biochemistry. --- Proteins. --- Life Sciences. --- Biochemistry, general. --- Receptors. --- Cell receptors --- Microbodies --- Cell receptors. --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Medical sciences --- Composition --- Proteins . --- Proteids --- Biomolecules --- Polypeptides --- Proteomics

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This book provides readers with a comprehensive overview of peroxisomes and their role in human diseases. It starts by describing the history of peroxisome research and then examines in detail the current understanding of the biogenesis and function of peroxisomes. It then focuses on peroxisomal disorders and the involvement of peroxisomes in cancer and age-related diseases, discussing in detail the use of model organisms to elucidate the pathogenesis of peroxisomal disorders and the physiological importance of peroxisomal proteins. Further, the book examines diagnostic and therapeutic strategies in peroxisomal disorders as well as significant recent advances. Lastly, it addresses various topics in peroxisome research, including the isolation of peroxisomes from mammalian tissues and cells, the structural biology of peroxisomal proteins, the lipidomics of peroxisomal disorders, the value of exome sequencing, and neuropsychological testing in X-linked adrenoleukodystrophy. Given its scope, the book is a valuable resource for postgraduate students and researchers in the life sciences and clinicians in the fields of internal medicine, pediatrics, and neurology.

Human physiology. --- Cell biology. --- Cell physiology. --- Biochemistry. --- Human Physiology. --- Cell Biology. --- Cell Physiology. --- Animal Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Cell function --- Cytology --- Physiology --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Human biology --- Human body --- Composition --- Peroxisomes. --- Peroxidosomes --- Peroxysoma --- Microbodies --- Bioquímica --- Malalties --- Malaltia --- Medicina --- Discapacitat física --- Malalties cardiovasculars --- Malalties constitucionals --- Malalties de l'aparell digestiu --- Malalties de l'aparell genital --- Malalties de l'aparell respiratori --- Malalties de la pell --- Malalties del sistema nerviós --- Malalties dels animals --- Malalties hematològiques --- Malalties hereditàries --- Malalties de l'aparell locomotor --- Malalties d'origen nutricional --- Malalties iatrogèniques --- Malalties immunitàries --- Malalties otorrinolaringològiques --- Malalties rares --- Oftalmopaties --- Serveis d'urgències mèdiques --- Síndromes --- Trastorns de la nutrició --- Trastorns del metabolisme --- Epidemiologia --- Química biològica --- Química fisiològica --- Biologia --- Química --- Absorció (Fisiologia) --- Anàlisi enzimàtica --- Biodegradació --- Biodisponibilitat --- Bioelectroquímica --- Bioenergètica --- Biogeoquímica --- Biologia molecular --- Bioquímica analítica --- Bioquímica clínica --- Bioquímica física --- Bioquímica quàntica --- Biosíntesi --- Centres actius (Bioquímica) --- Citoquímica --- Composició del cos humà --- Cromatografia --- Digestió --- Enginyeria bioquímica --- Enzimologia --- Equilibri àcid-base --- Fitoquímica --- Fixació de proteïnes --- Genètica bioquímica --- Immunoquímica --- Interfícies biològiques --- Lípids --- Lligands (Bioquímica) --- Marcadors bioquímics --- Metabolisme --- Minerals en l'organisme --- Neuroquímica --- Oxidació fisiològica --- Pigments (Biologia) --- Química biorgànica --- Química clínica --- Química microbiològica --- Quimiotaxi --- Quimiotaxonomia --- Toxicologia bioquímica --- Xenobiòtics --- Histoquímica