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Intermittent claudication is a symptom of peripheral arterial occlusive disease (PAD) of the lower limbs, often associated with atherosclerosis. It is responsible for a limitation of physical performance and walking ability and results in a quite important decreased quality of life. Its prevalence is between 1 and 4.5% of the world population, and affects 10 to 30% of individuals with PAD. The risk of progression of PAD to serious complications such as amputation is rare, but there are especially high risks of cardiac, cerebrovascular and aortic problems linked to atherothrombosis. The mechanism most often put forward to explain the characteristic pain of intermittent claudication relies on the reduced oxygen supply to muscles that follows the reduction of the arteries diameter associated with atherosclerotic plaques. However, this is not the only physiopathological mechanism, hemodynamics alterations, structural muscle changes, metabolic alterations and oxidative stress phenomena are also often found. The treatment of intermittent claudication is divided into two parts, the first one aimed at the reduction of the risk of cardiovascular events by reducing risk factors and therefore limiting the progression of atherosclerosis. The second intend the relief of IC symptoms and improvement of quality of life for the patients. The Belgian market provides several molecules capable of increasing walking distances like the naftidrofiryl, pentoxifylline or buflomedil whose effectiveness remains controversial. Cilostazol, a molecule marketed in the USA, seems to be the most effective, but there are some questions regarding its safety still without answers. That is the reason why this drug remains unavailable in Europe. Up to now, the most effective symptomatic treatment of intermittent claudication seems to be the supervised treadmill exercise. Given the lack of truly effective and safe treatment, various molecules and gene therapy are currently under study. This thesis provides an update on the subject that remains unrecognized by the health professionals La claudication intermittente est un symptôme de l’artériopathie oblitérante des membres inférieurs, une atteinte obstructive des artères des membres inférieurs (AOMI), dont la cause principale est l’athérosclérose. Elle est responsable d’une limitation de la performance physique et de la capacité de marche entraînant une baisse de qualité de vie assez importante. Sa prévalence serait entre 1 et 4,5% population mondiale et touche 10 à 30% des individus atteints d’AOML Le r d’évolution de l’AOMI vers des complications graves comme l’amputation est rare, mais il existe surtout un grand risque de complications cardiaques, vasculaires cérébrales et aortiques liées à l’athéro-thrombose. La diminution du diamètre des artères au niveau des plaques d’athérome limitant l’apport en oxygène aux muscles est le mécanisme le plus souvent mis en avance pour expliquer la douleur caractéristique de la claudication intermittente. Mais ceci n’est pas le seul mécanisme physiopathologique, on retrouve diverses altérations hémodynamiques, des modifications structurales des muscles, des altérations métaboliques et des phénomènes de stress oxydatif. Le traitement de la claudication intermittente est divisé en deux parties, la première consiste à réduire le risque d’évènements cardiovasculaires en limitant la progression de l’athérosclérose par la diminution des facteurs de risques. La deuxième partie consiste à soulager les symptômes de la CI et améliorer la qualité de vie des patients. Pour cela, il existe plusieurs molécules capables d’augmenter les distances de marche. Sur le marché belge, nous retrouvons le naftidrofuryl, le buflomédil et la pentoxifylline dont l’efficacité reste controversée. Le cilostazol, molécule commercialisée aux EUA, semble être la plus efficace, mais des questions se posent quant à sa sécurité. Face a ce doute, l’Europe ne lui a toujours pas cédé d’autorisation de mise sur le marché. Aujourd’hui, le traitement symptomatique le plus efficace de la claudication intermittente est l’exercice physique supervisé. Face à l’absence de traitement réellement efficace et sans risques, diverses molécules ainsi que la thérapie génétique sont actuellement en étude. Ce mémoire a pour but de faire le point sur ce sujet qui, encore aujourd’hui, est peu connu de la part des professionnels de la santé
Intermittent Claudication --- Peripheral Arterial Disease --- Atherosclerosis
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The current treatment of peripheral vascular disease is optimized by a collaborative approach among practitioners with expertise in vascular medicine, vascular imaging, open surgery, and endovascular intervention. The Handbook of Endovascular Peripheral Interventions is a comprehensive guide written by a multi-disciplinary group of expert authors to provide practical, focused chapters on the assessment and interventional management of peripheral vascular diseases. Covering all aspects of percutaneous peripheral vascular interventions, each chapter of this highly-illustrated book provides a brief background, etiology, clinical presentation, imaging, and percutaneous treatment of different vascular conditions. Importantly, Tips of the Trade and How I Do It sections within each chapter make the handbook practical for daily use and quick reference. Edited by Dr. Christopher D. Owens (Division of Vascular Surgery) and Dr. Yerem Yeghiazarians (Division of Interventional Cardiology), from the University of California San Francisco School of Medicine, the Handbook of Endovascular Peripheral Interventions is a collaborative effort between interventional cardiologists, vascular surgeons, and interventional radiologists who are experts in the field. Since each subspecialty brings unique expertise and experience to their work, this handbook will be a valuable resource for both beginning and advanced cardiologists, surgeons, and radiologists currently working in peripheral vascular interventions.
Physical methods for diagnosis --- Pathology of the circulatory system --- Surgery --- cardiologie --- cardiovasculaire chirurgie --- radiologie --- Endovascular Procedures --- Peripheral Arterial Disease --- Minimally Invasive Surgical Procedures --- Peripheral vascular diseases --- Maladies vasculaires périphériques --- methods --- Handbooks. --- surgery --- EPUB-LIV-FT LIVMEDEC SPRINGER-B
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vascular surgery --- endovascular treatment --- peripheral arterial disease --- aneurysm --- venous disease --- thrombosis --- Blood-vessels --- Vascular Surgical Procedures --- Surgery --- Procedure, Vascular Surgical --- Procedures, Vascular Surgical --- Surgical Procedure, Vascular --- Surgical Procedures, Vascular --- Vascular Surgical Procedure --- Blood Vessels --- Vascular surgery --- Angiology --- Vascular system --- Vasculature --- Cardiovascular system --- surgery
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The current treatment of peripheral vascular disease is optimized by a collaborative approach among practitioners with expertise in vascular medicine, vascular imaging, open surgery, and endovascular intervention. The Handbook of Endovascular Peripheral Interventions is a comprehensive guide written by a multi-disciplinary group of expert authors to provide practical, focused chapters on the assessment and interventional management of peripheral vascular diseases. Covering all aspects of percutaneous peripheral vascular interventions, each chapter of this highly-illustrated book provides a brief background, etiology, clinical presentation, imaging, and percutaneous treatment of different vascular conditions. Importantly, Tips of the Trade and How I Do It sections within each chapter make the handbook practical for daily use and quick reference. Edited by Dr. Christopher D. Owens (Division of Vascular Surgery) and Dr. Yerem Yeghiazarians (Division of Interventional Cardiology), from the University of California San Francisco School of Medicine, the Handbook of Endovascular Peripheral Interventions is a collaborative effort between interventional cardiologists, vascular surgeons, and interventional radiologists who are experts in the field. Since each subspecialty brings unique expertise and experience to their work, this handbook will be a valuable resource for both beginning and advanced cardiologists, surgeons, and radiologists currently working in peripheral vascular interventions.
Peripheral vascular diseases -- Treatment -- Handbooks, manuals, etc. --- Peripheral vascular diseases -- Treatment. --- Peripheral vascular diseases --- Publication Formats --- Peripheral Vascular Diseases --- Surgical Procedures, Operative --- Vascular Surgical Procedures --- Investigative Techniques --- Atherosclerosis --- Arteriosclerosis --- Publication Characteristics --- Cardiovascular Surgical Procedures --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Vascular Diseases --- Cardiovascular Diseases --- Arterial Occlusive Diseases --- Diseases --- Endovascular Procedures --- Peripheral Arterial Disease --- Methods --- Surgical Procedures, Minimally Invasive --- Handbooks --- Medicine --- Health & Biological Sciences --- Blood-vessels --- Endoscopic surgery --- Angiology --- Vascular system --- Vasculature --- Peripheral vascular disease --- Vascular diseases --- Medicine. --- Interventional radiology. --- Cardiology. --- Vascular surgery. --- Medicine & Public Health. --- Interventional Radiology. --- Vascular Surgery. --- Cardiovascular system --- Heart --- Internal medicine --- Vascular surgery --- Radiology, Interventional --- Medical radiology --- Therapeutics --- Interventional radiology .
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Biopolymers including natural (e.g., polysaccharides, proteins, gums, natural rubbers, bacterial polymers), synthetic (e.g., aliphatic polyesters and polyphosphoester), and biocomposites are of paramount interest in regenerative medicine, due to their availability, processability, and low toxicity. Moreover, the structuration of biopolymer-based materials at the nano- and microscale along with their chemical properties are crucial in the engineering of advanced carriers for drug products. Finally, combination products including or based on biopolymers for controlled drug release offer a powerful solution to improve the tissue integration and biological response of these materials. Understanding the drug delivery mechanisms, efficiency, and toxicity of such systems may be useful for regenerative medicine and pharmaceutical technology. The main aim of the Special Issue on “Biopolymers in Drug Delivery and Regenerative Medicine” is to gather recent findings and current advances on biopolymer research for biomedical applications, particularly in regenerative medicine, wound healing, and drug delivery. Contributions to this issue can be as original research or review articles and may cover all aspects of biopolymer research, ranging from the chemical synthesis and characterization of modified biopolymers, their processing in different morphologies and hierarchical structures, as well as their assessment for biomedical uses.
Medicine --- curcumin --- pectin aerogels --- chitosan coating --- burst release --- controlled release --- Keratose --- drug-coated balloon --- paclitaxel --- drug delivery --- pre-clinical --- peripheral arterial disease --- endovascular --- cellulose phosphate --- cellulose phosphate aerogel --- interconnected porosity --- supercritical carbon dioxide --- tetrabutylammonium fluoride --- TBAF/DMSO --- polysaccharide --- κ-carrageenan --- dexamethasone --- electrochemical active deliver system --- doping agent --- charged molecule --- conductive polymers --- colorectal cancer --- antioxidants --- 5-fluorouracil --- polymer nanomaterials --- nanocapsules --- chemotherapy --- cryogel --- starch --- NMR spectroscopy --- morphology --- drug release --- polysaccharides --- hydrogels --- prilling --- droplets --- ionotropic gelation --- drying --- xerogels --- cryogels --- aerogels --- lipid microparticles --- PGSS® --- supercritical CO2 --- modeling --- solvent-free technology --- biomaterials --- porous materials --- biomimetic --- multi-stimulation --- tissue engineering --- n/a
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The overarching goal of this book is to provide a current picture of the latest developments in the capabilities of biomedical photoacoustic imaging and sensing in an affordable setting, such as advances in the technology involving light sources, and delivery, acoustic detection, and image reconstruction and processing algorithms. This book includes 14 chapters from globally prominent researchers , covering a comprehensive spectrum of photoacoustic imaging topics from technology developments and novel imaging methods to preclinical and clinical studies, predominantly in a cost-effective setting. Affordability is undoubtedly an important factor to be considered in the following years to help translate photoacoustic imaging to clinics around the globe. This first-ever book focused on biomedical photoacoustic imaging and sensing using affordable resources is thus timely, especially considering the fact that this technique is facing an exciting transition from benchtop to bedside. Given its scope, the book will appeal to scientists and engineers in academia and industry, as well as medical experts interested in the clinical applications of photoacoustic imaging.
photoacoustic microscopy --- ultrasonic transducer --- optical-resolution photoacoustic microscopy --- transparent ultrasound transducer --- ultrasound stimulation --- photoacoustic --- LED --- clinic --- optical imaging --- tomography --- ultrasound --- small animal --- liver --- fibrosis --- optoacoustic --- spectral imaging --- blind source separation --- unsupervised unmixing --- photoacoustic imaging --- 3-D printed photoacoustic probe holder --- light delivery optimization --- LED divergence --- illumination scheme --- in vivo --- mouse --- Monte Carlo --- linear array --- tumor imaging --- LED-based photoacoustic imaging --- hair follicles --- FUE --- FUT --- photoacoustic computed tomography --- light-emitting diodes --- laser diodes --- oxygen saturation imaging --- photoacoustics --- fluence compensation --- hypoxia --- deep tissue imaging --- hemangioma --- laser --- light-emitting diodes (LED) --- mobile health --- peripheral arterial disease --- stroke --- vascular malformations --- signal enhancement --- pre-illumination --- photo-thermal effect --- heat capacity --- remote sensing --- endoscopy --- speckle --- n/a
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Biopolymers including natural (e.g., polysaccharides, proteins, gums, natural rubbers, bacterial polymers), synthetic (e.g., aliphatic polyesters and polyphosphoester), and biocomposites are of paramount interest in regenerative medicine, due to their availability, processability, and low toxicity. Moreover, the structuration of biopolymer-based materials at the nano- and microscale along with their chemical properties are crucial in the engineering of advanced carriers for drug products. Finally, combination products including or based on biopolymers for controlled drug release offer a powerful solution to improve the tissue integration and biological response of these materials. Understanding the drug delivery mechanisms, efficiency, and toxicity of such systems may be useful for regenerative medicine and pharmaceutical technology. The main aim of the Special Issue on “Biopolymers in Drug Delivery and Regenerative Medicine” is to gather recent findings and current advances on biopolymer research for biomedical applications, particularly in regenerative medicine, wound healing, and drug delivery. Contributions to this issue can be as original research or review articles and may cover all aspects of biopolymer research, ranging from the chemical synthesis and characterization of modified biopolymers, their processing in different morphologies and hierarchical structures, as well as their assessment for biomedical uses.
curcumin --- pectin aerogels --- chitosan coating --- burst release --- controlled release --- Keratose --- drug-coated balloon --- paclitaxel --- drug delivery --- pre-clinical --- peripheral arterial disease --- endovascular --- cellulose phosphate --- cellulose phosphate aerogel --- interconnected porosity --- supercritical carbon dioxide --- tetrabutylammonium fluoride --- TBAF/DMSO --- polysaccharide --- κ-carrageenan --- dexamethasone --- electrochemical active deliver system --- doping agent --- charged molecule --- conductive polymers --- colorectal cancer --- antioxidants --- 5-fluorouracil --- polymer nanomaterials --- nanocapsules --- chemotherapy --- cryogel --- starch --- NMR spectroscopy --- morphology --- drug release --- polysaccharides --- hydrogels --- prilling --- droplets --- ionotropic gelation --- drying --- xerogels --- cryogels --- aerogels --- lipid microparticles --- PGSS® --- supercritical CO2 --- modeling --- solvent-free technology --- biomaterials --- porous materials --- biomimetic --- multi-stimulation --- tissue engineering --- n/a
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Biopolymers including natural (e.g., polysaccharides, proteins, gums, natural rubbers, bacterial polymers), synthetic (e.g., aliphatic polyesters and polyphosphoester), and biocomposites are of paramount interest in regenerative medicine, due to their availability, processability, and low toxicity. Moreover, the structuration of biopolymer-based materials at the nano- and microscale along with their chemical properties are crucial in the engineering of advanced carriers for drug products. Finally, combination products including or based on biopolymers for controlled drug release offer a powerful solution to improve the tissue integration and biological response of these materials. Understanding the drug delivery mechanisms, efficiency, and toxicity of such systems may be useful for regenerative medicine and pharmaceutical technology. The main aim of the Special Issue on “Biopolymers in Drug Delivery and Regenerative Medicine” is to gather recent findings and current advances on biopolymer research for biomedical applications, particularly in regenerative medicine, wound healing, and drug delivery. Contributions to this issue can be as original research or review articles and may cover all aspects of biopolymer research, ranging from the chemical synthesis and characterization of modified biopolymers, their processing in different morphologies and hierarchical structures, as well as their assessment for biomedical uses.
Medicine --- curcumin --- pectin aerogels --- chitosan coating --- burst release --- controlled release --- Keratose --- drug-coated balloon --- paclitaxel --- drug delivery --- pre-clinical --- peripheral arterial disease --- endovascular --- cellulose phosphate --- cellulose phosphate aerogel --- interconnected porosity --- supercritical carbon dioxide --- tetrabutylammonium fluoride --- TBAF/DMSO --- polysaccharide --- κ-carrageenan --- dexamethasone --- electrochemical active deliver system --- doping agent --- charged molecule --- conductive polymers --- colorectal cancer --- antioxidants --- 5-fluorouracil --- polymer nanomaterials --- nanocapsules --- chemotherapy --- cryogel --- starch --- NMR spectroscopy --- morphology --- drug release --- polysaccharides --- hydrogels --- prilling --- droplets --- ionotropic gelation --- drying --- xerogels --- cryogels --- aerogels --- lipid microparticles --- PGSS® --- supercritical CO2 --- modeling --- solvent-free technology --- biomaterials --- porous materials --- biomimetic --- multi-stimulation --- tissue engineering --- curcumin --- pectin aerogels --- chitosan coating --- burst release --- controlled release --- Keratose --- drug-coated balloon --- paclitaxel --- drug delivery --- pre-clinical --- peripheral arterial disease --- endovascular --- cellulose phosphate --- cellulose phosphate aerogel --- interconnected porosity --- supercritical carbon dioxide --- tetrabutylammonium fluoride --- TBAF/DMSO --- polysaccharide --- κ-carrageenan --- dexamethasone --- electrochemical active deliver system --- doping agent --- charged molecule --- conductive polymers --- colorectal cancer --- antioxidants --- 5-fluorouracil --- polymer nanomaterials --- nanocapsules --- chemotherapy --- cryogel --- starch --- NMR spectroscopy --- morphology --- drug release --- polysaccharides --- hydrogels --- prilling --- droplets --- ionotropic gelation --- drying --- xerogels --- cryogels --- aerogels --- lipid microparticles --- PGSS® --- supercritical CO2 --- modeling --- solvent-free technology --- biomaterials --- porous materials --- biomimetic --- multi-stimulation --- tissue engineering
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Medicine has evolved into a high level of specialization using the very detailed imaging of organs. This has impressively solved a multitude of acute health-related problems linked to single-organ diseases. Many diseases and pathophysiological processes, however, involve more than one organ. An organ-based approach is challenging when considering disease prevention and caring for elderly patients, or those with systemic chronic diseases or multiple co-morbidities. In addition, medical imaging provides more than a pretty picture. Much of the data are now revealed by quantitating algorithms with or without artificial intelligence. This Special Issue on “Systems Radiology and Personalized Medicine” includes reviews and original studies that show the strengths and weaknesses of structural and functional whole-body imaging for personalized medicine.
Medicine --- COVID-19 --- chest X-ray --- deep learning --- convolutional neural network --- Grad-CAM --- computed tomography --- image analysis --- osteoarthritis --- reliability --- FDG-PET/CT --- infection --- bloodstream infection --- endocarditis --- vascular graft infection --- spondylodiscitis --- cyst infection --- white blood cell scintigraphy --- total body PET/CT --- radiotracers --- artificial intelligence --- contrast media --- body composition --- large vessel vasculitis --- atherosclerosis --- imaging --- FDG-PET --- radiological imaging --- MRI --- non-contrast --- venography --- TRANCE --- QFlow --- neuroblastoma --- nuclear medicine --- radionuclide imaging --- [123I]mIBG --- [124I]mIBG --- [18F]mFBG --- [18F]FDG --- [68Ga]Ga-DOTA peptides --- [18F]F-DOPA --- [11C]mHED --- chronic limb-threatening ischemia --- peripheral arterial disease --- calcification pattern --- diffuse idiopathic skeletal hyperostosis --- risk factors --- adiposity --- intra-abdominal fat --- cardiorenal syndrome --- imaging biomarker --- tissue characterization --- cerebral aneurysm --- computational fluid dynamics --- hemodynamic --- morphological --- rupture --- COVID-19 --- chest X-ray --- deep learning --- convolutional neural network --- Grad-CAM --- computed tomography --- image analysis --- osteoarthritis --- reliability --- FDG-PET/CT --- infection --- bloodstream infection --- endocarditis --- vascular graft infection --- spondylodiscitis --- cyst infection --- white blood cell scintigraphy --- total body PET/CT --- radiotracers --- artificial intelligence --- contrast media --- body composition --- large vessel vasculitis --- atherosclerosis --- imaging --- FDG-PET --- radiological imaging --- MRI --- non-contrast --- venography --- TRANCE --- QFlow --- neuroblastoma --- nuclear medicine --- radionuclide imaging --- [123I]mIBG --- [124I]mIBG --- [18F]mFBG --- [18F]FDG --- [68Ga]Ga-DOTA peptides --- [18F]F-DOPA --- [11C]mHED --- chronic limb-threatening ischemia --- peripheral arterial disease --- calcification pattern --- diffuse idiopathic skeletal hyperostosis --- risk factors --- adiposity --- intra-abdominal fat --- cardiorenal syndrome --- imaging biomarker --- tissue characterization --- cerebral aneurysm --- computational fluid dynamics --- hemodynamic --- morphological --- rupture
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The overarching goal of this book is to provide a current picture of the latest developments in the capabilities of biomedical photoacoustic imaging and sensing in an affordable setting, such as advances in the technology involving light sources, and delivery, acoustic detection, and image reconstruction and processing algorithms. This book includes 14 chapters from globally prominent researchers , covering a comprehensive spectrum of photoacoustic imaging topics from technology developments and novel imaging methods to preclinical and clinical studies, predominantly in a cost-effective setting. Affordability is undoubtedly an important factor to be considered in the following years to help translate photoacoustic imaging to clinics around the globe. This first-ever book focused on biomedical photoacoustic imaging and sensing using affordable resources is thus timely, especially considering the fact that this technique is facing an exciting transition from benchtop to bedside. Given its scope, the book will appeal to scientists and engineers in academia and industry, as well as medical experts interested in the clinical applications of photoacoustic imaging.
Medicine --- photoacoustic microscopy --- ultrasonic transducer --- optical-resolution photoacoustic microscopy --- transparent ultrasound transducer --- ultrasound stimulation --- photoacoustic --- LED --- clinic --- optical imaging --- tomography --- ultrasound --- small animal --- liver --- fibrosis --- optoacoustic --- spectral imaging --- blind source separation --- unsupervised unmixing --- photoacoustic imaging --- 3-D printed photoacoustic probe holder --- light delivery optimization --- LED divergence --- illumination scheme --- in vivo --- mouse --- Monte Carlo --- linear array --- tumor imaging --- LED-based photoacoustic imaging --- hair follicles --- FUE --- FUT --- photoacoustic computed tomography --- light-emitting diodes --- laser diodes --- oxygen saturation imaging --- photoacoustics --- fluence compensation --- hypoxia --- deep tissue imaging --- hemangioma --- laser --- light-emitting diodes (LED) --- mobile health --- peripheral arterial disease --- stroke --- vascular malformations --- signal enhancement --- pre-illumination --- photo-thermal effect --- heat capacity --- remote sensing --- endoscopy --- speckle --- photoacoustic microscopy --- ultrasonic transducer --- optical-resolution photoacoustic microscopy --- transparent ultrasound transducer --- ultrasound stimulation --- photoacoustic --- LED --- clinic --- optical imaging --- tomography --- ultrasound --- small animal --- liver --- fibrosis --- optoacoustic --- spectral imaging --- blind source separation --- unsupervised unmixing --- photoacoustic imaging --- 3-D printed photoacoustic probe holder --- light delivery optimization --- LED divergence --- illumination scheme --- in vivo --- mouse --- Monte Carlo --- linear array --- tumor imaging --- LED-based photoacoustic imaging --- hair follicles --- FUE --- FUT --- photoacoustic computed tomography --- light-emitting diodes --- laser diodes --- oxygen saturation imaging --- photoacoustics --- fluence compensation --- hypoxia --- deep tissue imaging --- hemangioma --- laser --- light-emitting diodes (LED) --- mobile health --- peripheral arterial disease --- stroke --- vascular malformations --- signal enhancement --- pre-illumination --- photo-thermal effect --- heat capacity --- remote sensing --- endoscopy --- speckle
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