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Peptide and Peptidomimetic Therapeutics: From Bench to Beside offers applied, evidence-based instruction on developing and applying peptide therapeutics in disease treatment, driving drug discovery, and improving patient care. Here, researchers, clinicians and students will find tools to harness the full power of peptides and peptidomimetics and improve bioavailability, stability, efficiency and selectivity of new therapeutics and their application in treatment plans. More than 20 leaders in the field share their approaches for identifying and advancing peptide and peptidomimetic therapeutics. Topics examined run from "bench to bedside," beginning with fundamental peptide science, protein-protein interactions and peptide synthesis. Later chapters examine modes for peptide drug delivery, including cell penetration peptide and peptidomimetic delivery, as well as the targeting of specific disease types, peptide therapeutics as applied to infectious disease, cancer, metabolic disorders, neurodegenerative disorders, and skin disorders, and antiparasitic and immunosuppressive peptidomimetics.
Peptide drugs. --- Peptide drugs --- Design. --- Peptide pharmaceuticals --- Drugs --- Peptides --- Peptidomimetics --- Drug Design --- pharmacology --- therapeutic use
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Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics. Describes advances in application of powerful techniques in a wide bioscience areaChapters are written by authorities in their fieldTargeted to a wide audience of researchers, specialists, and studentsThe information provided in the volume is well s
Peptides --- Proteins --- Peptide drugs. --- Peptide pharmaceuticals --- Drugs --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Organic compounds --- Amino acids --- Therapeutic use.
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Allergies --- Allergieën --- Allergy --- -Antigenic determinants --- Peptide drugs --- Academic collection --- Antigen determinants --- Antigenic determinant groups --- Determinants, Antigenic --- Epitopes --- Epitypes --- Antigens --- Immunospecificity --- Allergic diseases --- Hypersensitivity --- Hypersensitivity, Immediate --- Immediate allergy --- Immediate hypersensitivity --- Immunologic diseases --- Immunoglobulin E --- Peptide pharmaceuticals --- Drugs --- Immunotherapy --- Theses --- Antigenic determinants
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Leading scientists offer detailed profiles of ten protein drugs currently in development. The case histories of these important new compounds are described from the perspective of their formulation, characterization, and stability. This ready reference also features recent data and an abundance of previously unpublished information. The in-depth coverage includes a highly useful compendium of degradation sites occurring in over 70 proteins. An invaluable aid in the rapid identification of potential `hot spots' in proteins, this accessible compilation allows for inspection of the protein's primary structure and preparation of a hydroflex plot.
Protein drugs. --- Peptide drugs. --- Toxicology. --- Pharmacy. --- Pharmacology/Toxicology. --- Pharmacology. --- Chemistry --- Medicine --- Drugs --- Materia medica --- Pharmacology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Pharmacy --- Physiological effect --- Peptide pharmaceuticals --- Protein pharmaceuticals
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This book covers the latest developments in the physical biology of proteins and peptides. Key insights into microscopic and macroscopic approaches to describe biologically relevant macromolecules and their interactions are provided. This book also covers a wide range of tools, including theoretical methods as statistical mechanics, normal mode analysis, kinetic theory and stochastic processes, and all-atom and coarse-grained molecular dynamics simulations. New experimental techniques are also discussed, particularly related to amiloidogenic peptides and their mutations. This is an excellent book for molecular biologists, physicists, computational scientists, and chemists. It covers cutting-edge research in this exciting, interdisciplinary research field. This book also: Discusses the latest developments in the physical biology of proteins, peptides and enzymes covering theoretical, computational, and experimental approaches B roadens readers’ understanding on the role of intra- and inter-molecular interactions as a fundamental cornerstone of macroscopic biological properties of macromolecules Provides a wide and useful perspective on different aspects of the physics, biology, and chemistry of proteins and peptides suitable for interdisciplinary research .
Biochemistry --- Chemistry --- Physical Sciences & Mathematics --- Proteins --- Peptide drugs. --- Therapeutic use. --- Metabolism. --- Peptide pharmaceuticals --- Protein metabolism --- Proteids --- Life sciences. --- Bioinformatics. --- Proteins. --- Biophysics. --- Biological physics. --- Life Sciences. --- Protein Science. --- Protein Structure. --- Computational Biology/Bioinformatics. --- Biophysics and Biological Physics. --- Drugs --- Biomolecules --- Polypeptides --- Proteomics --- Biochemistry. --- Biological and Medical Physics, Biophysics. --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Systems biology --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Medical sciences --- Data processing --- Composition --- Proteins . --- Biological physics --- Physics --- Life sciences --- Bioinformatics --- Biophysics
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Macromolecular (specifically peptide-based) drugs could potentially be highly effective medicines. However they have a relatively short duration of action and variable therapeutic index. An example of such a peptide is Glucagon-like Peptide I which could potentially be used as a revolutionary drug for diabetes. This is because it stimulates insulin only when the blood glucose level is high thereby reducing the risk of hypoglycemia (a significant disadvantage of using insulin is that an insulin overdose is the single most potent cause of life-threatening hypoglycemia). However it’s short duration of action (half-life of 2 minutes in plasma) precludes its therapeutic use. In this volume, the use of novel therapeutics like GLP1 as an alternative to tradition insulin-based drugs in diabetes is described. Application of Peptide-Based Prodrug Chemistry in Drug Development elucidates the traditional concept of prodrugs as “specialized non-toxic protective groups used in a transient manner to alter or to eliminate certain limiting properties in the parent small molecule” (IUPAC definition). It goes on to provide insight into how prodrugs of peptides (with GLP1 as an example) could be appropriately used to extend the biological half life, broaden the therapeutic index of macromolecules and improve the pharmacodynamics of such drugs. Author explains the logic behind designing peptide prodrugs, synthetic procedures and bioassays to examine the conversion of the prodrug to the drug under therapeutic conditions. The prodrugs described slowly convert to the parent drug at physiological conditions of 37C and pH 7.2 driven by their inherent chemical instability without the need of any enzymatic cleavage. The diketopiperazine and diketomorpholine (DKP and DMP) strategies for prodrug conversion are demonstrated in detail with special emphasis on the chemical flexibility that it offers to develop prodrugs with variable time actions. This book will be of useful to chemists, biochemists, medicinal chemists, biologists and people in the medical profession (doctors). It may be used in undergraduate classes but will certainly help post-graduate students and advanced professionals. The author is grateful to Prof. Richard DiMarchi (Standiford H. Cox Professor of Chemistry and the Linda & Jack Gill Chair in Biomolecular Sciences at Indiana University) for valuable suggestions. The foreword for the book has been written by Prof. Jean Martinez, (Legion d'Honneur awarded by the French Republic; Professor of Chemistry and Medicinal Chemistry of the University of Montpellier, France; and Chairman of European Peptide Society, 2002-2010).
Peptide drugs --- Drugs --- Drug design --- Pharmaceutical design --- Peptide pharmaceuticals --- Physiological transport. --- Design. --- Medicine. --- Pharmacology. --- Pharmaceutical technology. --- Diabetes. --- Biomedicine. --- Pharmaceutical Sciences/Technology. --- Pharmacology/Toxicology. --- Drug development --- Toxicology. --- Brittle diabetes --- Diabetes mellitus --- IDDM (Disease) --- Insulin-dependent diabetes --- Ketosis prone diabetes --- Type 1 diabetes --- Carbohydrate intolerance --- Endocrine glands --- Diabetic acidosis --- Glycosylated hemoglobin --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Diseases --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Pharmacy --- Physiological effect
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This book explains how peptide-based drug design works, what steps are needed to develop a peptide-based therapeutic, and challenges in synthesis as well as regulatory issues. It covers the design concept of peptide therapeutics from fundamental principles using structural biology and computational approaches. The chapters are arranged in a linear fashion. A fresh graduate or a scientist who works on small molecules can use this to follow the design and development of peptide therapeutics to use as understanding the basic concepts. Each chapter is written by experts from academia as well as industry. Rather than covering extensive literature, the book provides concepts of design, synthesis, delivery, as well as regulatory affairs and manufacturing of peptides in a systematic way with examples in each case. The book can be used as a reference for a pharmaceutical or biomedical scientist or graduate student who wants to pursue their career in peptide therapeutics. Some chapters will be written as a combination of basic principles and protocol so that scientists can adopt these methods to their research work. The examples provided can be used to perform peptide formulation considerations for the designed peptides. The book has nine chapters, and each chapter can be read as an independent unit on a particular concept.
Pharmaceutical chemistry. --- Peptide drugs. --- Peptide pharmaceuticals --- Drugs --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Chemistry --- Drug delivery systems. --- Pharmacology. --- Pharmacy. --- Proteins --- Pharmaceutics. --- Drug Delivery. --- Structure-Based Drug Design. --- Protein Synthesis and Translation. --- Design. --- Synthesis. --- Protein biosynthesis --- Protein synthesis --- Medicine --- Materia medica --- Pharmacology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Pharmacy --- Drug design --- Pharmaceutical design --- Drug development --- Delivery systems, Drug --- Drug administration technology --- Drug delivery technology --- Pharmaceutical technology --- Metabolism --- Physiological effect --- Delivery systems --- Medicaments peptídics --- Química farmacèutica
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Peptides --- Proteins --- Protéines --- Therapeutic use --- Emploi en thérapeutique --- Peptide drugs --- Drugs --- Protein drugs --- Metabolism --- Congresses --- Dosage forms --- Administration --- -Peptide drugs --- -Peptides --- -Protein drugs --- -Proteins --- -Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Protein pharmaceuticals --- Organic compounds --- Amino acids --- Peptide pharmaceuticals --- Medicaments --- Medications --- Medicine (Drugs) --- Medicines (Drugs) --- Pharmaceuticals --- Prescription drugs --- Bioactive compounds --- Medical supplies --- Pharmacopoeias --- Chemotherapy --- Materia medica --- Pharmacology --- Pharmacy --- -Congresses --- Biopharmaceutics --- Chemistry, Pharmaceutical --- Dosage Forms --- Congresses. --- congresses. --- -Administration --- Protéines --- Emploi en thérapeutique --- Proteins - Metabolism - Congresses --- Peptide drugs - Dosage forms - Congresses --- Drugs - Administration - Congresses --- Peptides - Metabolism - Congresses --- Protein drugs - Dosage forms - Congresses --- Bile --- Calcitonin --- Insulin --- Interferons --- Microbial degradation --- Toxicity
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