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Proteases and protease inhibitors in Alzheimer's disease pathogenesis
Authors: ---
ISBN: 0897667778 Year: 1992 Publisher: New York, NY : New York Academy of Sciences,

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Intramembrane-cleaving proteases (I-CLiPs)
Authors: ---
ISBN: 1280944064 9786610944064 1402063113 1402063105 9048176042 Year: 2007 Publisher: Dordrect : Springer,

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Abstract

In recent years a growing number of proteases have been identified that catalyse peptide bond hydrolysis in the plane of the cellular membrane. These so-called ‘intramembrane-cleaving proteases’ (I-CLiPs) are involved in a diverse range of cellular processes, including cell regulation, signalling, quorum sensing, protein processing, lipid metabolism and the unfolded protein response. Some I-CLiPs play critical roles in diseases such as Alzheimer’s and viral infection. The authors, who are all world leaders in this exciting field of cell biology, provide an overview of the various proteases including recent data derived from the structural determination of some of the I-CliPs, and discuss the various roles that these proteases play in biology and disease. The aim of this book is to provide an update on this emerging group of unusual but important proteases for both the specialist and those with a broader interest in proteases. Amongst the target audience will be protease researchers, enzymologists, those working in academia and the pharmaceutical industry on biological processes and diseases involving I-CLiPs.

Cellular peptidases in immune functions and diseases 2
Authors: ---
ISBN: 0306463830 9786610042906 1280042907 0306468263 Year: 2000 Volume: 477 Publisher: New York Kluwer Academic/Plenum

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