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ALZHEIMER DISEASE --- PEPTIDE PEPTIDOHYDROLASES --- PROTEASE INHIBITORS --- ETIOLOGY --- PHYSIOPATHOLOGY
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In recent years a growing number of proteases have been identified that catalyse peptide bond hydrolysis in the plane of the cellular membrane. These so-called ‘intramembrane-cleaving proteases’ (I-CLiPs) are involved in a diverse range of cellular processes, including cell regulation, signalling, quorum sensing, protein processing, lipid metabolism and the unfolded protein response. Some I-CLiPs play critical roles in diseases such as Alzheimer’s and viral infection. The authors, who are all world leaders in this exciting field of cell biology, provide an overview of the various proteases including recent data derived from the structural determination of some of the I-CliPs, and discuss the various roles that these proteases play in biology and disease. The aim of this book is to provide an update on this emerging group of unusual but important proteases for both the specialist and those with a broader interest in proteases. Amongst the target audience will be protease researchers, enzymologists, those working in academia and the pharmaceutical industry on biological processes and diseases involving I-CLiPs.
Endopeptidases. --- Proteolytic enzymes --- Metabolism. --- Peptide hydrolases --- Proteases --- Hydrolases --- Peptide peptidohydrolases --- Peptidase --- Pathology. --- Neurosciences. --- Cytology. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Disease (Pathology) --- Diseases --- Medicine --- Medicine, Preventive --- Cell biology.
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Peptidase --- Endopeptidases --- Immunology --- Pathophysiology --- Congresses --- Endopeptidase --- Immunology. --- Biochemistry. --- Rheumatology. --- Oncology . --- Biochemistry, general. --- Oncology. --- Medical Biochemistry. --- Medical biochemistry. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology --- Tumors --- Internal medicine --- Connective tissues --- Joints --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Immunobiology --- Life sciences --- Serology --- Diseases --- Composition --- Peptide peptidohydrolases --- Proteolytic enzymes --- Transpeptidation
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Protease inhibitors --- Amyloid beta-protein precursor --- Proteolytic enzymes --- Alzheimer's disease --- Alzheimer Disease --- Endopeptidases --- Metabolism --- Pathogenesis --- etiology --- physiopathology --- Alzheimer's Disease --- Peptide Peptidohydrolases --- Protease Inhibitors --- congresses. --- Congresses --- Proteolitic enzyme inhibitors --- Alzheimer's disease - Pathogenesis - Congresses. --- Amyloid beta-protein precursor - Metabolism - Congresses. --- Proteolytic enzymes - Congresses. --- Proteolytic enzyme inhibitors - Congresses. --- Amyloid beta-protein precursor - Metabolism --- Alzheimer's disease - Pathogenesis --- Alzheimer Disease - etiology - congresses --- Endopeptidases - congresses --- Alzheimer Disease - physiopathology - congresses
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Enzymology --- Oncology. Neoplasms --- Endopeptidases --- Neoplasm Invasiveness --- Metastasis --- Proteinase --- Cancer invasiveness --- Métastases --- Cancer --- Caractère envahissant --- Lymphatic Metastasis. --- Cysteine Proteases. --- Endopeptidases. --- Peptide Peptidohydrolases --- Cysteine Protease --- Cysteine Proteinase --- Cysteine Proteinases --- Protease, Cysteine --- Proteases, Cysteine --- Proteinase, Cysteine --- Proteinases, Cysteine --- Lymphatic Metastases --- Metastases, Lymphatic --- Metastasis, Lymphatic --- Sentinel Lymph Node --- Sentinel Lymph Node Biopsy --- diagnosis. --- Conferences - Meetings --- Métastases --- Caractère envahissant --- Cysteine Proteases --- Lymphatic Metastasis --- Proteolytic enzymes --- Dissemination of cancer --- Invasiveness (Oncology) --- Neoplasm invasiveness --- Spread of cancer --- Tumor dissemination --- Tumor invasiveness --- Tumor progression --- Tumor spread --- Cancer cells --- Congresses --- diagnosis --- Growth --- Lymph Node Metastasis --- Lymph Node Metastases --- Metastasis, Lymph Node --- Endopeptidase
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