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Airworthiness, as a field, encompasses the technical and non-technical activities required to design, certify, produce, maintain, and safely operate an aircraft throughout its lifespan. The evolving technology, science, and engineering methods and, most importantly, aviation regulation, offer new opportunities and create, new challenges for the aviation industry. This book assembles review and research articles across a variety of topics in the field of airworthiness: aircraft maintenance, safety management, human factors, cost analysis, structures, risk assessment, unmanned aerial vehicles and regulations. This selection of papers informs the industry practitioners and researchers on important issues.

risk assessment --- n/a --- surveillance sensor --- human factors --- fault tree analysis --- airworthiness --- structural health monitoring --- aviation --- aerospace structures --- NASGRO --- additive manufacturing --- payload --- Ti-6Al-4V --- crack growth --- safety --- guided waves --- Cost Per Flying Hour --- military --- communication --- aviation engineering --- prevention --- condition-based maintenance --- “open” category --- sense and avoid --- risk management --- design organization --- parametric model --- operating and support cost --- safety management system --- trust --- repair --- life cycle cost --- trainees --- borescope inspection --- UAS --- professionals --- reliability --- EASA --- 316L stainless steel --- error --- risk behaviours --- composites --- aviation maintenance --- cost-benefit analysis --- risk perception factors --- scheduled maintenance --- and overhaul (MRO) --- reliability centered maintenance --- unmanned aircraft systems --- F-16C/D --- maintenance planning optimization --- AerMet100 steel --- human error --- ADS-B --- Bowtie analysis --- visual inspection --- sensors --- Life Cycle Cost --- unified analytical framework --- F-35A --- aircraft system --- impact detection --- importance measure --- maintenance --- importance measures --- "open" category

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This book is a compendium of scientific articles submitted to a Special Issue of International Journal of Molecular Sciences, fostered by MDPI and curated by Dr. Annamaria Sandomenico and Dr. Menotti Ruvo from the Institute of Biostructure and Bioimaging of the National Research Council. All articles underwent a rigorous peer review and were selected to highlight the properties that make monoclonal antibodies and their functional fragments some of the most useful and versatile assets in therapy and diagnosis.

Technology: general issues --- porcine deltacoronavirus --- nucleocapsid --- monoclonal antibodies --- neurodegenerative disorders --- affibody molecules --- blood–brain barrier --- receptor-mediated transcytosis --- transferrin receptor --- AL amyloidosis --- CD38 --- anti-CD38 MoAb --- Daratumumab --- Isatuximab --- myeloma --- BCMA --- bispecific T-cell engager --- antibody-drug conjugates --- chimeric antigen receptor T-cells --- belantamab mafodotin --- idecabtagene vicleucel --- JNJ-68284528 --- Mabs --- Antibody-Drug Conjugate --- cancer therapy --- drug targeting --- payload --- cross-linking --- antibody fragment --- Fab --- scFv --- E. coli --- YKL-40 --- CHI3L1 --- monoclonal antibody --- phage display --- lung metastasis --- prostate-specific membrane antigen --- in vivo imaging --- prostate cancer --- glutamate carboxypeptidase II --- NAALADase --- immunization --- antibody --- protocol --- guinea pig --- cDNA --- chimeric antigen receptor (CAR T) --- universal CAR T --- modular CAR T --- universal immune receptor --- CAR adaptor --- adoptive immunotherapy --- split CAR --- bispecific --- polyspecificity --- pharmacokinetics --- solubility --- aggregation --- viscosity --- developability --- stability --- affinity --- specificity --- protein engineering --- self-association --- non-specific binding --- immunogenicity --- antibody fragments --- single chain --- amyloid --- oligomer --- neurotoxicity --- NUsc1

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This book is a compendium of scientific articles submitted to a Special Issue of International Journal of Molecular Sciences, fostered by MDPI and curated by Dr. Annamaria Sandomenico and Dr. Menotti Ruvo from the Institute of Biostructure and Bioimaging of the National Research Council. All articles underwent a rigorous peer review and were selected to highlight the properties that make monoclonal antibodies and their functional fragments some of the most useful and versatile assets in therapy and diagnosis.

Technology: general issues --- porcine deltacoronavirus --- nucleocapsid --- monoclonal antibodies --- neurodegenerative disorders --- affibody molecules --- blood–brain barrier --- receptor-mediated transcytosis --- transferrin receptor --- AL amyloidosis --- CD38 --- anti-CD38 MoAb --- Daratumumab --- Isatuximab --- myeloma --- BCMA --- bispecific T-cell engager --- antibody-drug conjugates --- chimeric antigen receptor T-cells --- belantamab mafodotin --- idecabtagene vicleucel --- JNJ-68284528 --- Mabs --- Antibody-Drug Conjugate --- cancer therapy --- drug targeting --- payload --- cross-linking --- antibody fragment --- Fab --- scFv --- E. coli --- YKL-40 --- CHI3L1 --- monoclonal antibody --- phage display --- lung metastasis --- prostate-specific membrane antigen --- in vivo imaging --- prostate cancer --- glutamate carboxypeptidase II --- NAALADase --- immunization --- antibody --- protocol --- guinea pig --- cDNA --- chimeric antigen receptor (CAR T) --- universal CAR T --- modular CAR T --- universal immune receptor --- CAR adaptor --- adoptive immunotherapy --- split CAR --- bispecific --- polyspecificity --- pharmacokinetics --- solubility --- aggregation --- viscosity --- developability --- stability --- affinity --- specificity --- protein engineering --- self-association --- non-specific binding --- immunogenicity --- antibody fragments --- single chain --- amyloid --- oligomer --- neurotoxicity --- NUsc1

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This book is a compilation of works covering applied mathematical methods and their applications in complex engineering problems. The methods covered in this book include modeling and simulation, computation, analysis, control, optimization, data science, and machine learning. The engineering application topics include but are not limited to environmental engineering, cybersecurity, transportation, agriculture, smart grid, and next-generation manufacturing.

History of engineering & technology --- Phoronomics --- mechanics --- kinetics --- kinematics --- direction cosines --- Euler angles --- space dynamics --- digital computation --- control systems --- control engineering --- industrial cyber-physical systems --- cyber-attacks --- neural network --- model predictive control --- nonlinear chemical processes --- network classification --- network evolution --- network symmetries --- Green’s symmetry problem --- network invariants --- network internal dynamics --- symmetry ensembles --- propensities --- energy --- opening capability --- security --- smart grid --- group signature --- anonymous signature --- autonomous vehicle --- target detection --- multi-sensors --- fusion --- YOLO --- linear response eigenvalue problem --- block methods --- weighted Golub-Kahan-Lanczos algorithm --- convergence analysis --- thick restart --- mining vibrating screen --- theoretical rigid body model --- spring failures diagnosis --- amplitudes change --- real-time optimization --- nonlinear processes --- process control --- chemical reactor control --- distillation column control --- energy-based control --- payload swing attenuation --- linear matrix inequalities --- quadrotor --- larger Lipschitz constants --- comparative advantage --- transaction cost --- specialized production --- infra-marginal model --- agricultural division of labor --- velocity-slip --- temperature-jump --- homotopy analysis method --- nanofluids --- power-law fluids --- state estimation --- parameter estimation --- moving horizon estimation --- extended kalman filter --- ensemble kalman filter --- richards equation --- agro-hydrological systems --- economic model predictive control --- chemical processes --- responsive control --- artificial intelligence --- interpretability --- controller verification --- seashore soft soil --- cement --- sulfuric acid erosion --- stress–strain behavior --- mathematical model --- Micro Grid --- optimization theory --- optimization --- MATLAB simulation

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CFD is an emerging area and is gaining popularity due to the availability of ever-increasing computational power. If used accurately, CFD methods may overcome the limitations of experimental and other numerical methods, in some respects. This Special Issue focuses on Computational Fluid Dynamics (CFD) Simulations of Marine Hydrodynamics with a specific focus on the applications of naval architecture and ocean engineering, and it comprises 24 original articles that advance state-of-the-art CFD applications in marine hydrodynamics and/or review the progress and future directions of research in this field. The published articles cover a wide range of subjects relevant to naval architecture and ocean engineering, including but not limited to; ship resistance and propulsion, seakeeping and maneuverability, hydrodynamics of marine renewable energy devices, validation and verification of computational fluid dynamics (CFD), EFD/CFD combined methods, fouling/coating hydrodynamics.

CFD --- shallow water --- restricted water --- KCS --- spectral analysis of free surfaces --- air resistance --- container ship --- superstructure --- numerical simulation --- trim --- dispersion --- pH --- turbulent Schmidt number --- scrubber --- wash water --- ship hydrodynamics --- ship motions --- green water on deck --- slamming --- cross wave --- near free surface --- unsteady cavitation dynamics --- NACA66 hydrofoil --- dynamic mode decomposition --- wave energy --- computational fluid dynamics --- identification --- viscous damping --- URANS --- computational fluid dynamic --- experimental fluid dynamic --- sailboat --- hull --- towing tank test --- numerical ventilation --- overset --- volume of fluid (VOF), hydrodynamic --- Polito Sailing Team (PST) --- offshore crane --- OpenFOAM --- wave-payload interaction --- NWT --- overset mesh --- planing hull --- seakeeping --- vertical motions --- mesh deformation --- computational fluid dynamics (CFD) --- radial basis function (RBF) method --- inverse distance weighted (IDW) method --- hull form optimization --- Computational Fluid Dynamics --- Verification and Validation --- nearfield wake pattern --- longitudinal wake profile --- distributed propulsion --- draft --- parallel-sided --- NACA --- CAD --- systematic investigation --- low Reynolds number --- sailing --- centerboard --- Bézier curves --- gamma transition criterion --- restricted channel --- resistance correction --- biofouling --- ship performance --- oil tanker --- bulk carrier --- immersed boundary method --- air–water two-phase flows --- VoF method --- finite volume method --- interaction effect --- wind drag --- aerodynamic --- Reynolds Average Navier–Stokes (RANS) --- rudder–propeller interactions --- validations and verification --- actuator disk theory --- rudder sectional forces --- marginal ice zone --- sea ice --- wave --- six degree of freedom (6DoF) motion --- planing craft --- twin side-hulls --- porpoising instability --- model tests --- inhibition mechanism --- optimal location --- ship resistance --- form factor --- best practice guidelines --- numerical friction line --- combined CFD/EFD methods --- next generation subsea production system --- Immersed Buoyant Platform --- hydrodynamic characteristics --- ultra-deep sea --- swallowing capacity --- duct flow --- ducted turbine --- roughness effect --- Wigley hull --- heterogeneous hull roughness